SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d4u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 3d4u CARBOXYPEPTIDASE B2
(Bos
taurus) 		5 / 11 LEU A  80
GLY A  84
THR A  87
VAL A  33
VAL A  52
 None
 0.96A 1akdA-3d4uA:
undetectable		 1akdA-3d4uA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 3d4u CARBOXYPEPTIDASE B2
(Bos
taurus) 		4 / 7 PHE A  82
LEU A  50
VAL A  33
LEU A 100
 None
 0.94A 1hk3A-3d4uA:
undetectable		 1hk3A-3d4uA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3d4u CARBOXYPEPTIDASE B2
(Bos
taurus) 		5 / 11 LEU A  80
GLY A  84
THR A  87
VAL A  33
VAL A  52
 None
 0.90A 2a1nA-3d4uA:
undetectable		 2a1nA-3d4uA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 3d4u CARBOXYPEPTIDASE B2
(Bos
taurus) 		4 / 7 SER A 199
SER A 197
PHE A 279
GLU A 270
 None
None
None
ZN  A 309 ( 4.8A)
 1.31A 2c8aA-3d4uA:
undetectable		 2c8aA-3d4uA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 3d4u CARBOXYPEPTIDASE B2
(Bos
taurus) 		5 / 7 GLY A 278
SER A 199
SER A 197
PHE A 279
GLU A 270
 None
None
None
None
ZN  A 309 ( 4.8A)
 1.34A 2c8aB-3d4uA:
undetectable		 2c8aB-3d4uA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 3d4u CARBOXYPEPTIDASE B2
(Bos
taurus) 		4 / 6 SER A 199
SER A 197
PHE A 279
GLU A 270
 None
None
None
ZN  A 309 ( 4.8A)
 1.36A 2c8aC-3d4uA:
undetectable		 2c8aC-3d4uA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 3d4u CARBOXYPEPTIDASE B2
(Bos
taurus) 		4 / 5 SER A 197
LEU A 280
GLY A 278
ARG A 124
 None
 0.97A 2j2pA-3d4uA:
undetectable
2j2pB-3d4uA:
undetectable		 2j2pA-3d4uA:
19.60
2j2pB-3d4uA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 3d4u CARBOXYPEPTIDASE B2
(Bos
taurus) 		4 / 6 ARG A 124
SER A 197
LEU A 280
GLY A 278
 None
 1.03A 2j2pD-3d4uA:
undetectable
2j2pF-3d4uA:
undetectable		 2j2pD-3d4uA:
19.60
2j2pF-3d4uA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 3d4u CARBOXYPEPTIDASE B2
(Bos
taurus) 		4 / 6 GLU A 292
MET A 195
PHE A  78
ILE A  74
 None
 1.18A 2w98B-3d4uA:
undetectable		 2w98B-3d4uA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 3d4u CARBOXYPEPTIDASE B2
(Bos
taurus) 		3 / 3 GLU A 270
HIS A  69
GLU A  72
 ZN  A 309 ( 4.8A)
ZN  A 309 ( 3.1A)
ZN  A 309 (-2.1A)
 0.80A 2x45B-3d4uA:
undetectable		 2x45B-3d4uA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 3d4u CARBOXYPEPTIDASE B2
(Bos
taurus) 		3 / 3 GLU A 270
HIS A  69
GLU A  72
 ZN  A 309 ( 4.8A)
ZN  A 309 ( 3.1A)
ZN  A 309 (-2.1A)
 0.82A 2x45C-3d4uA:
undetectable		 2x45C-3d4uA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3d4u CARBOXYPEPTIDASE B2
(Bos
taurus) 		4 / 8 THR A 239
GLN A 200
TYR A 198
SER A 246
 None
 1.22A 2xz5C-3d4uA:
undetectable
2xz5D-3d4uA:
undetectable		 2xz5C-3d4uA:
20.75
2xz5D-3d4uA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3d4u CARBOXYPEPTIDASE B2
(Bos
taurus) 		5 / 10 GLY A 253
PHE A 147
HIS A  69
THR A 268
ILE A  68
 None
None
ZN  A 309 ( 3.1A)
None
None
 1.09A 2y7wB-3d4uA:
undetectable		 2y7wB-3d4uA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3d4u CARBOXYPEPTIDASE B2
(Bos
taurus) 		5 / 12 ILE A 164
ASN A 144
GLY A 253
ASP A 255
LEU A 249
 None
ACT  A 601 (-3.8A)
None
None
None
 1.25A 2zw9A-3d4uA:
undetectable		 2zw9A-3d4uA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 3d4u CARBOXYPEPTIDASE B2
(Bos
taurus) 		5 / 12 ILE A 189
LEU A 183
ASN A 144
ILE A  64
VAL A 304
 None
None
ACT  A 601 (-3.8A)
None
None
 1.14A 3a51C-3d4uA:
undetectable		 3a51C-3d4uA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 3d4u CARBOXYPEPTIDASE B2
(Bos
taurus) 		5 / 12 ARG A 210
ASP A 256
SER A 254
GLU A 154
ALA A 250
 None
 1.27A 3t7sA-3d4uA:
undetectable		 3t7sA-3d4uA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 3d4u CARBOXYPEPTIDASE B2
(Bos
taurus) 		5 / 12 ARG A 210
ASP A 256
SER A 254
GLU A 154
ALA A 250
 None
 1.26A 3t7sB-3d4uA:
undetectable		 3t7sB-3d4uA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 3d4u CARBOXYPEPTIDASE B2
(Bos
taurus) 		5 / 12 ARG A 210
ASP A 256
SER A 254
GLU A 154
ALA A 250
 None
 1.25A 3t7sD-3d4uA:
undetectable		 3t7sD-3d4uA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 3d4u CARBOXYPEPTIDASE B2
(Bos
taurus) 		4 / 7 GLY A 253
ASN A 144
GLY A 167
THR A 168
 None
ACT  A 601 (-3.8A)
None
None
 0.83A 3tajA-3d4uA:
undetectable		 3tajA-3d4uA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 3d4u CARBOXYPEPTIDASE B2
(Bos
taurus) 		3 / 3 TRP A  73
VAL A 113
TRP A 120
 None
 1.15A 3zq8A-3d4uA:
undetectable
3zq8B-3d4uA:
undetectable		 3zq8A-3d4uA:
5.59
3zq8B-3d4uA:
5.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 3d4u CARBOXYPEPTIDASE B2
(Bos
taurus) 		5 / 12 ILE A  22
GLY A  84
THR A  87
VAL A  33
VAL A  52
 None
 1.04A 4c9lA-3d4uA:
undetectable		 4c9lA-3d4uA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 3d4u CARBOXYPEPTIDASE B2
(Bos
taurus) 		5 / 12 ILE A  22
GLY A  84
THR A  87
VAL A  33
VAL A  52
 None
 1.02A 4c9oA-3d4uA:
undetectable		 4c9oA-3d4uA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 3d4u CARBOXYPEPTIDASE B2
(Bos
taurus) 		5 / 12 ILE A  22
GLY A  84
THR A  87
VAL A  33
VAL A  52
 None
 1.03A 4c9oB-3d4uA:
undetectable		 4c9oB-3d4uA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 3d4u CARBOXYPEPTIDASE B2
CARBOXYPEPTIDASE
INHIBITOR
(Bos
taurus;
Rhipicephalus
bursa) 		3 / 3 GLU A  72
TRP B  73
ASN A 144
 ZN  A 309 (-2.1A)
None
ACT  A 601 (-3.8A)
 1.02A 5dv4A-3d4uA:
undetectable		 5dv4A-3d4uA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JDC_D_6JPD302_1
(PTERIDINE REDUCTASE)		 3d4u CARBOXYPEPTIDASE B2
(Bos
taurus) 		5 / 11 HIS A  69
ARG A 184
ASP A  65
TYR A 192
VAL A 176
 ZN  A 309 ( 3.1A)
None
None
None
None
 1.44A 5jdcA-3d4uA:
undetectable
5jdcD-3d4uA:
undetectable		 5jdcA-3d4uA:
20.96
5jdcD-3d4uA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 3d4u CARBOXYPEPTIDASE B2
(Bos
taurus) 		5 / 12 LEU A 100
ILE A 107
PHE A 105
ILE A 300
ALA A 296
 None
 1.15A 5vc0A-3d4uA:
undetectable		 5vc0A-3d4uA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 3d4u CARBOXYPEPTIDASE B2
CARBOXYPEPTIDASE
INHIBITOR
(Bos
taurus;
Rhipicephalus
bursa) 		3 / 3 ARG A  71
PHE B   8
LEU B  11
 None
 0.82A 5veuA-3d4uA:
undetectable		 5veuA-3d4uA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 3d4u CARBOXYPEPTIDASE B2
(Bos
taurus) 		5 / 12 MET A 103
ALA A 298
VAL A 222
ASP A 255
PHE A 267
 None
 1.29A 5vlmD-3d4uA:
undetectable		 5vlmD-3d4uA:
19.02