SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d54'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		5 / 11 ILE D  93
GLY D  84
PHE D  89
TYR D  10
ALA D  63
 None
 1.39A 1ju6A-3d54D:
undetectable		 1ju6A-3d54D:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		5 / 10 ILE D  93
GLY D  84
PHE D  89
TYR D  10
ALA D  63
 None
 1.40A 1ju6C-3d54D:
undetectable		 1ju6C-3d54D:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		5 / 10 GLY D  96
ALA D  73
ASN D 175
ALA D  76
ILE D  72
 None
 1.03A 1likA-3d54D:
3.2		 1likA-3d54D:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		4 / 8 LEU D  23
PHE D 204
PHE D 130
LEU D 157
 None
 0.88A 1wrlC-3d54D:
undetectable
1wrlD-3d54D:
undetectable		 1wrlC-3d54D:
19.00
1wrlD-3d54D:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		4 / 6 LEU D  92
ASN D 175
ILE D  82
PHE D 181
 None
 0.81A 1xf1B-3d54D:
2.0		 1xf1B-3d54D:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		5 / 12 MET D 184
ALA D 171
SER D 166
ASN D 164
GLY D 172
 CYG  D  86 ( 3.4A)
None
None
None
None
 1.38A 2dcfA-3d54D:
undetectable		 2dcfA-3d54D:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		5 / 9 ILE D 136
THR D 127
VAL D 119
ALA D 171
LEU D 183
 None
 1.08A 2m9qA-3d54D:
undetectable		 2m9qA-3d54D:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		5 / 11 MET D 184
ALA D 171
SER D 166
ASN D 164
GLY D 172
 CYG  D  86 ( 3.4A)
None
None
None
None
 1.36A 2zmaA-3d54D:
undetectable		 2zmaA-3d54D:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		5 / 12 MET D 184
ALA D 171
SER D 166
ASN D 164
GLY D 172
 CYG  D  86 ( 3.4A)
None
None
None
None
 1.35A 3a65A-3d54D:
undetectable		 3a65A-3d54D:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A66_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		5 / 10 MET D 184
ALA D 171
SER D 166
ASN D 164
GLY D 172
 CYG  D  86 ( 3.4A)
None
None
None
None
 1.34A 3a66A-3d54D:
0.0		 3a66A-3d54D:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		5 / 12 ILE D  72
ALA D  75
ILE D  46
LEU D  39
LEU D  92
 None
 1.00A 3dzuA-3d54D:
undetectable		 3dzuA-3d54D:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 3d54 FORMYLGLYCINAMIDE
RIBONUCLEOTIDE
AMIDOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 ASP B   9
ARG B  80
ARG B  40
 None
 0.97A 3k37A-3d54B:
undetectable		 3k37A-3d54B:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		5 / 12 LEU D  92
GLY D  49
GLY D  84
LEU D 183
ALA D 141
 None
CYG  D  86 ( 3.5A)
None
None
CYG  D  86 ( 4.6A)
 0.96A 3ou6A-3d54D:
undetectable		 3ou6A-3d54D:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWP_A_ACAA503_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		5 / 10 MET D 184
ALA D 171
SER D 166
ASN D 164
GLY D 172
 CYG  D  86 ( 3.4A)
None
None
None
None
 1.35A 3vwpA-3d54D:
0.0		 3vwpA-3d54D:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		5 / 12 MET D 184
ALA D 171
SER D 166
ASN D 164
GLY D 172
 CYG  D  86 ( 3.4A)
None
None
None
None
 1.35A 3vwqA-3d54D:
undetectable		 3vwqA-3d54D:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWR_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		5 / 11 MET D 184
ALA D 171
SER D 166
ASN D 164
GLY D 172
 CYG  D  86 ( 3.4A)
None
None
None
None
 1.35A 3vwrA-3d54D:
undetectable		 3vwrA-3d54D:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		5 / 12 GLY D  84
TYR D 159
LEU D 157
HIS D 142
LEU D 102
 None
 1.15A 4emaA-3d54D:
undetectable		 4emaA-3d54D:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		4 / 7 TYR D  42
VAL D   8
ILE D  72
ILE D  82
 None
 0.89A 4lv9A-3d54D:
undetectable		 4lv9A-3d54D:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		4 / 7 TYR D  42
VAL D   8
ILE D  72
ILE D  82
 None
 0.91A 4lv9B-3d54D:
undetectable		 4lv9B-3d54D:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		5 / 12 GLY D 200
LEU D 183
PHE D 130
ASN D 128
SER D 206
 None
 1.15A 4pb1A-3d54D:
undetectable		 4pb1A-3d54D:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		5 / 12 GLY D 200
LEU D 183
PHE D 130
ASN D 128
SER D 206
 None
 1.17A 4pd9A-3d54D:
undetectable		 4pd9A-3d54D:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLD_A_BRLA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		5 / 12 GLY D  84
TYR D 159
LEU D 157
HIS D 142
LEU D 102
 None
 1.18A 4xldA-3d54D:
undetectable		 4xldA-3d54D:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		4 / 8 ILE D  46
PHE D 204
ASN D  26
PRO D 187
 None
 0.92A 5x23A-3d54D:
undetectable		 5x23A-3d54D:
19.91