SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d5e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE
(Homo
sapiens) 		4 / 8 GLY A 366
THR A 358
GLY A 373
ASP A 376
 None
 0.79A 1aegA-3d5eA:
undetectable		 1aegA-3d5eA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA995_1
(GLUCOAMYLASE GLU1)		 3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE
(Homo
sapiens) 		5 / 12 TYR A 103
TRP A 203
GLY A 199
ARG A 180
GLU A 178
 None
 1.35A 2f6dA-3d5eA:
undetectable		 2f6dA-3d5eA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE
(Homo
sapiens) 		4 / 7 THR A 361
GLY A 366
LEU A 121
PHE A 125
 None
 1.02A 2vl2B-3d5eA:
undetectable		 2vl2B-3d5eA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE
(Homo
sapiens) 		4 / 8 ALA A 380
ILE A 381
ASN A 353
PRO A  57
 None
 0.90A 3fxrA-3d5eA:
undetectable		 3fxrA-3d5eA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE
(Homo
sapiens) 		4 / 8 LEU A 398
PRO A  86
GLY A  61
PRO A  62
 None
 0.96A 3hcrA-3d5eA:
2.9		 3hcrA-3d5eA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE
(Homo
sapiens) 		5 / 11 TYR A 321
GLY A 348
ALA A 380
ASP A 374
ILE A 375
 None
 1.22A 3id5B-3d5eA:
2.8		 3id5B-3d5eA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE
(Homo
sapiens) 		5 / 11 TYR A 321
GLY A 348
ALA A 380
ASP A 374
ILE A 375
 None
 1.22A 3id5F-3d5eA:
undetectable		 3id5F-3d5eA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE
(Homo
sapiens) 		4 / 6 SER A 150
PHE A 274
ASP A 181
PRO A 301
 None
 1.41A 3jqaC-3d5eA:
5.3		 3jqaC-3d5eA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE
(Homo
sapiens) 		4 / 6 SER A 150
PHE A 274
ASP A 181
PRO A 301
 None
 1.41A 3jqaD-3d5eA:
3.9		 3jqaD-3d5eA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE
(Homo
sapiens) 		4 / 6 ASN A 421
ILE A 422
GLU A 320
ASN A 318
 None
 1.13A 3kp6A-3d5eA:
undetectable
3kp6B-3d5eA:
undetectable		 3kp6A-3d5eA:
18.23
3kp6B-3d5eA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE
(Homo
sapiens) 		3 / 3 ASP A 181
SER A 183
ARG A 218
 None
 0.89A 3loqA-3d5eA:
undetectable		 3loqA-3d5eA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE
(Homo
sapiens) 		3 / 3 GLU A 305
GLU A 220
ASN A 219
 None
 0.75A 3lp9B-3d5eA:
undetectable
3lp9D-3d5eA:
undetectable		 3lp9B-3d5eA:
22.37
3lp9D-3d5eA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE
(Homo
sapiens) 		5 / 12 GLY A 152
GLY A 271
SER A 150
ALA A 226
SER A 284
 DEP  A 473 (-3.5A)
None
None
None
None
 1.24A 3sueD-3d5eA:
undetectable		 3sueD-3d5eA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE
(Homo
sapiens) 		3 / 3 TYR A 160
LEU A 235
ARG A 157
 None
 0.65A 3sufB-3d5eA:
undetectable		 3sufB-3d5eA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE
(Homo
sapiens) 		5 / 11 LEU A 146
ALA A 268
LEU A 396
GLY A 171
LEU A 167
 None
 1.14A 3uudA-3d5eA:
undetectable		 3uudA-3d5eA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7A_A_MXDA1002_1
(ANDROGEN RECEPTOR)		 3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE
(Homo
sapiens) 		3 / 3 GLU A 214
TRP A 298
LYS A 210
 None
DEP  A 473 (-3.7A)
None
 1.08A 4k7aA-3d5eA:
undetectable		 4k7aA-3d5eA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE
(Homo
sapiens) 		4 / 8 ILE A 163
HIS A 179
HIS A 151
THR A 278
 None
 0.85A 4n16A-3d5eA:
undetectable		 4n16A-3d5eA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE
(Homo
sapiens) 		5 / 9 PHE A 289
ILE A 267
THR A  79
LEU A  81
LEU A  83
 None
 1.05A 4ze0A-3d5eA:
undetectable		 4ze0A-3d5eA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE
(Homo
sapiens) 		4 / 6 TYR A 144
GLY A  66
SER A  87
LEU A 138
 None
 1.08A 5bphD-3d5eA:
undetectable		 5bphD-3d5eA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE
(Homo
sapiens) 		5 / 12 GLY A 271
ALA A 277
ILE A 293
LEU A 295
ALA A 155
 None
 0.82A 5bw4B-3d5eA:
undetectable		 5bw4B-3d5eA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE
(Homo
sapiens) 		5 / 10 LEU A 146
ALA A 268
LEU A 396
GLY A 171
LEU A 167
 None
 1.19A 5dxbA-3d5eA:
undetectable		 5dxbA-3d5eA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE
(Homo
sapiens) 		3 / 3 VAL A 269
HIS A 151
VAL A 177
 None
 0.71A 5jmnC-3d5eA:
undetectable		 5jmnC-3d5eA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE
(Homo
sapiens) 		5 / 12 LEU A 124
ALA A 360
GLY A 126
THR A 129
LEU A 371
 None
None
None
FMT  A  11 (-3.6A)
None
 1.00A 5nfjA-3d5eA:
undetectable		 5nfjA-3d5eA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE
(Homo
sapiens) 		5 / 12 LEU A 124
ALA A 360
GLY A 126
THR A 129
LEU A 371
 None
None
None
FMT  A  11 (-3.6A)
None
 1.05A 5nfjB-3d5eA:
undetectable		 5nfjB-3d5eA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE
(Homo
sapiens) 		5 / 12 LEU A 124
ALA A 360
GLY A 126
THR A 129
LEU A 371
 None
None
None
FMT  A  11 (-3.6A)
None
 1.06A 5nfjC-3d5eA:
undetectable		 5nfjC-3d5eA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE
(Homo
sapiens) 		5 / 12 PHE A  80
PHE A 190
THR A  68
LEU A 251
MET A  71
 None
 1.31A 5v5zA-3d5eA:
undetectable		 5v5zA-3d5eA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE
(Homo
sapiens) 		3 / 3 ALA A 162
VAL A 174
TYR A  84
 None
 0.71A 5zmqH-3d5eA:
undetectable		 5zmqH-3d5eA:
19.26