SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d5l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3d5l REGULATORY PROTEIN
RECX
(Lactobacillus
reuteri) 		3 / 3 ASP A  67
THR A  88
PRO A  89
 None
 0.68A 2pynB-3d5lA:
undetectable		 2pynB-3d5lA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 3d5l REGULATORY PROTEIN
RECX
(Lactobacillus
reuteri) 		3 / 3 ASP A  67
THR A  88
PRO A  89
 None
 0.65A 2qakB-3d5lA:
undetectable		 2qakB-3d5lA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 3d5l REGULATORY PROTEIN
RECX
(Lactobacillus
reuteri) 		5 / 10 ALA A  61
LEU A  97
LEU A  83
LYS A  82
LEU A 100
 None
 1.19A 2riwA-3d5lA:
undetectable
2riwB-3d5lA:
undetectable		 2riwA-3d5lA:
21.78
2riwB-3d5lA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3d5l REGULATORY PROTEIN
RECX
(Lactobacillus
reuteri) 		4 / 6 THR A 189
PHE A 192
LEU A 167
LEU A 163
 None
 1.15A 3bgdA-3d5lA:
undetectable		 3bgdA-3d5lA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 3d5l REGULATORY PROTEIN
RECX
(Lactobacillus
reuteri) 		5 / 9 TYR A  24
ILE A  18
VAL A  28
ILE A  49
ILE A  52
 None
 0.98A 3p4wB-3d5lA:
undetectable		 3p4wB-3d5lA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 3d5l REGULATORY PROTEIN
RECX
(Lactobacillus
reuteri) 		5 / 10 TYR A  24
ILE A  18
VAL A  28
ILE A  49
ILE A  52
 None
 0.99A 3p4wD-3d5lA:
undetectable		 3p4wD-3d5lA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 3d5l REGULATORY PROTEIN
RECX
(Lactobacillus
reuteri) 		5 / 10 TYR A  24
ILE A  18
VAL A  28
ILE A  49
ILE A  52
 None
 0.99A 3p4wE-3d5lA:
undetectable		 3p4wE-3d5lA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3d5l REGULATORY PROTEIN
RECX
(Lactobacillus
reuteri) 		5 / 12 GLY A 126
PRO A 127
GLY A 128
LEU A 124
LEU A 167
 None
 0.81A 4n48A-3d5lA:
undetectable		 4n48A-3d5lA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3d5l REGULATORY PROTEIN
RECX
(Lactobacillus
reuteri) 		5 / 12 GLY A 126
PRO A 127
GLY A 128
LEU A 124
LEU A 167
 None
 0.89A 4n49A-3d5lA:
undetectable		 4n49A-3d5lA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3d5l REGULATORY PROTEIN
RECX
(Lactobacillus
reuteri) 		4 / 4 GLU A  94
PRO A  95
ILE A  96
LEU A  97
 None
 1.15A 5m45A-3d5lA:
undetectable		 5m45A-3d5lA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3d5l REGULATORY PROTEIN
RECX
(Lactobacillus
reuteri) 		4 / 4 GLU A  94
PRO A  95
ILE A  96
LEU A  97
 None
 1.20A 5m45D-3d5lA:
undetectable		 5m45D-3d5lA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3d5l REGULATORY PROTEIN
RECX
(Lactobacillus
reuteri) 		4 / 4 GLU A  94
PRO A  95
ILE A  96
LEU A  97
 None
 1.18A 5m45G-3d5lA:
undetectable		 5m45G-3d5lA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3d5l REGULATORY PROTEIN
RECX
(Lactobacillus
reuteri) 		4 / 4 GLU A  94
PRO A  95
ILE A  96
LEU A  97
 None
 1.22A 5m45J-3d5lA:
0.4		 5m45J-3d5lA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 3d5l REGULATORY PROTEIN
RECX
(Lactobacillus
reuteri) 		3 / 3 PHE A  36
ARG A  37
GLN A  35
 None
 1.12A 6g1pB-3d5lA:
undetectable		 6g1pB-3d5lA:
20.00