SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d5n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3d5n Q97W15_SULSO
(Sulfolobus
solfataricus) 		4 / 5 SER A  76
THR A  75
GLU A  12
GLY A  13
 None
 1.21A 1icrA-3d5nA:
undetectable
1icrB-3d5nA:
undetectable		 1icrA-3d5nA:
22.22
1icrB-3d5nA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3d5n Q97W15_SULSO
(Sulfolobus
solfataricus) 		4 / 5 SER A  76
THR A  75
GLU A  12
GLY A  13
 None
 1.22A 1icvC-3d5nA:
undetectable
1icvD-3d5nA:
undetectable		 1icvC-3d5nA:
22.22
1icvD-3d5nA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 3d5n Q97W15_SULSO
(Sulfolobus
solfataricus) 		5 / 12 ILE A 133
ALA A 150
ARG A  15
ILE A  46
PHE A 138
 None
 1.40A 1y0xX-3d5nA:
undetectable		 1y0xX-3d5nA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3d5n Q97W15_SULSO
(Sulfolobus
solfataricus) 		4 / 7 LEU A  81
ASN A   2
ILE A   3
ASP A  88
 None
 0.84A 1yc2E-3d5nA:
undetectable		 1yc2E-3d5nA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 3d5n Q97W15_SULSO
(Sulfolobus
solfataricus) 		4 / 8 ASP A  60
THR A  28
PRO A  29
LEU A  22
 None
 0.87A 1z2bB-3d5nA:
undetectable		 1z2bB-3d5nA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3d5n Q97W15_SULSO
(Sulfolobus
solfataricus) 		4 / 8 GLY A   4
VAL A   5
PHE A 138
ILE A 133
 None
 0.89A 4fglD-3d5nA:
undetectable		 4fglD-3d5nA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3d5n Q97W15_SULSO
(Sulfolobus
solfataricus) 		4 / 7 ILE A  31
PRO A  98
ILE A 175
ASP A 174
 None
 1.08A 4w5oA-3d5nA:
undetectable		 4w5oA-3d5nA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3d5n Q97W15_SULSO
(Sulfolobus
solfataricus) 		4 / 7 ILE A  31
PRO A  98
ILE A 175
ASP A 174
 None
 1.06A 4z4eA-3d5nA:
undetectable		 4z4eA-3d5nA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3d5n Q97W15_SULSO
(Sulfolobus
solfataricus) 		4 / 7 ILE A  31
PRO A  98
ILE A 175
ASP A 174
 None
 1.05A 4z4gA-3d5nA:
undetectable		 4z4gA-3d5nA:
13.90