SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d5t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 3d5t MALATE DEHYDROGENASE
(Burkholderia
pseudomallei) 		5 / 12 PHE A 220
LEU A 168
LEU A 165
ALA A 164
ILE A 300
 None
 1.13A 1crbA-3d5tA:
undetectable		 1crbA-3d5tA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 3d5t MALATE DEHYDROGENASE
(Burkholderia
pseudomallei) 		6 / 12 LEU A 165
ALA A 199
GLY A 203
PRO A 175
VAL A 176
ILE A 179
 None
 1.44A 2f8gB-3d5tA:
undetectable		 2f8gB-3d5tA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3d5t MALATE DEHYDROGENASE
(Burkholderia
pseudomallei) 		5 / 12 GLN A  40
VAL A 251
HIS A 250
ALA A   9
PHE A  79
 None
 1.35A 2g70A-3d5tA:
4.9		 2g70A-3d5tA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3d5t MALATE DEHYDROGENASE
(Burkholderia
pseudomallei) 		5 / 12 GLN A  40
VAL A 251
HIS A 250
ALA A   9
PHE A  79
 None
 1.44A 2g70B-3d5tA:
5.1		 2g70B-3d5tA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 3d5t MALATE DEHYDROGENASE
(Burkholderia
pseudomallei) 		6 / 12 LEU A 165
ALA A 199
GLY A 203
PRO A 175
VAL A 176
ILE A 179
 None
 1.47A 3k4vA-3d5tA:
undetectable		 3k4vA-3d5tA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 3d5t MALATE DEHYDROGENASE
(Burkholderia
pseudomallei) 		6 / 12 LEU A 165
ALA A 199
GLY A 203
PRO A 175
VAL A 176
ILE A 179
 None
 1.49A 3k4vB-3d5tA:
undetectable		 3k4vB-3d5tA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3d5t MALATE DEHYDROGENASE
(Burkholderia
pseudomallei) 		4 / 8 ASN A 152
THR A 154
LEU A 128
ALA A  85
 None
 1.04A 3kp6A-3d5tA:
undetectable		 3kp6A-3d5tA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3d5t MALATE DEHYDROGENASE
(Burkholderia
pseudomallei) 		3 / 3 ASN A 132
ASN A 135
GLU A 318
 None
 0.93A 3kpdB-3d5tA:
undetectable		 3kpdB-3d5tA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 3d5t MALATE DEHYDROGENASE
(Burkholderia
pseudomallei) 		6 / 12 LEU A 165
ALA A 199
GLY A 203
PRO A 175
VAL A 176
ILE A 179
 None
 1.49A 3lzuB-3d5tA:
undetectable		 3lzuB-3d5tA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_3
(PROTEASE)		 3d5t MALATE DEHYDROGENASE
(Burkholderia
pseudomallei) 		6 / 12 LEU A 165
ALA A 199
GLY A 203
PRO A 175
VAL A 176
ILE A 179
 None
 1.48A 3ndtB-3d5tA:
undetectable		 3ndtB-3d5tA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_3
(PROTEASE)		 3d5t MALATE DEHYDROGENASE
(Burkholderia
pseudomallei) 		5 / 12 LEU A 165
ALA A 199
GLY A 203
PRO A 175
VAL A 176
 None
 0.98A 3oxcB-3d5tA:
undetectable		 3oxcB-3d5tA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 3d5t MALATE DEHYDROGENASE
(Burkholderia
pseudomallei) 		6 / 12 LEU A 165
ALA A 199
GLY A 203
PRO A 175
VAL A 176
ILE A 179
 None
 1.47A 3tl9A-3d5tA:
undetectable		 3tl9A-3d5tA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3d5t MALATE DEHYDROGENASE
(Burkholderia
pseudomallei) 		3 / 3 SER A 166
ASP A 249
ASP A  29
 None
 0.69A 3uj7A-3d5tA:
5.8		 3uj7A-3d5tA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 3d5t MALATE DEHYDROGENASE
(Burkholderia
pseudomallei) 		4 / 8 VAL A  51
VAL A  55
ASP A  73
GLN A  48
 None
 1.05A 3uy4A-3d5tA:
3.3		 3uy4A-3d5tA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3d5t MALATE DEHYDROGENASE
(Burkholderia
pseudomallei) 		4 / 6 ILE A 267
THR A 154
VAL A 295
ASP A 195
 None
 1.14A 4iaqA-3d5tA:
undetectable		 4iaqA-3d5tA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3d5t MALATE DEHYDROGENASE
(Burkholderia
pseudomallei) 		4 / 6 VAL A   8
LEU A  39
LEU A  21
PHE A 110
 None
 1.07A 4o1zA-3d5tA:
undetectable		 4o1zA-3d5tA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 3d5t MALATE DEHYDROGENASE
(Burkholderia
pseudomallei) 		3 / 3 ARG A 319
GLU A 277
TYR A 139
 None
 0.95A 4r29D-3d5tA:
undetectable		 4r29D-3d5tA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 3d5t MALATE DEHYDROGENASE
(Burkholderia
pseudomallei) 		4 / 5 LEU A  86
ALA A  82
VAL A  37
ILE A  38
 None
 0.90A 4xe3B-3d5tA:
undetectable		 4xe3B-3d5tA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3d5t MALATE DEHYDROGENASE
(Burkholderia
pseudomallei) 		5 / 12 LEU A  21
LEU A  58
VAL A  10
GLY A  12
ALA A  13
 None
 1.09A 5ikrB-3d5tA:
undetectable		 5ikrB-3d5tA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 3d5t MALATE DEHYDROGENASE
(Burkholderia
pseudomallei) 		5 / 12 ILE A 221
PHE A 220
ALA A 183
LEU A 168
VAL A 224
 None
 1.17A 5km9B-3d5tA:
undetectable		 5km9B-3d5tA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3d5t MALATE DEHYDROGENASE
(Burkholderia
pseudomallei) 		4 / 8 LEU A 117
LEU A  86
ILE A  71
GLN A  48
 None
 1.01A 5ljbA-3d5tA:
undetectable		 5ljbA-3d5tA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 3d5t MALATE DEHYDROGENASE
(Burkholderia
pseudomallei) 		5 / 12 VAL A  10
ASN A 245
ALA A  18
LEU A  58
LEU A  39
 None
 0.95A 5xxiA-3d5tA:
undetectable		 5xxiA-3d5tA:
21.94