SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d62'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 3d62 3C-LIKE PROTEINASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 12 LEU A 202
ASN A 203
LEU A 205
ALA A 206
THR A 111
 None
 1.36A 2aa6A-3d62A:
undetectable		 2aa6A-3d62A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 3d62 3C-LIKE PROTEINASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 8 SER A 144
TYR A 161
HIS A 172
HIS A 163
 959  A 350 ( 4.4A)
None
None
None
 1.30A 2bteA-3d62A:
undetectable		 2bteA-3d62A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 3d62 3C-LIKE PROTEINASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 8 SER A 144
TYR A 161
HIS A 172
HIS A 163
 959  A 350 ( 4.4A)
None
None
None
 1.33A 2bteD-3d62A:
undetectable		 2bteD-3d62A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3d62 3C-LIKE PROTEINASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 6 HIS A  41
ASP A 176
THR A 175
TYR A 161
 959  A 350 (-3.9A)
None
None
None
 1.39A 2dysA-3d62A:
undetectable
2dysC-3d62A:
undetectable		 2dysA-3d62A:
20.46
2dysC-3d62A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3d62 3C-LIKE PROTEINASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 7 HIS A  41
ASP A 176
THR A 175
TYR A 161
 959  A 350 (-3.9A)
None
None
None
 1.41A 2eilA-3d62A:
undetectable
2eilC-3d62A:
undetectable		 2eilA-3d62A:
20.46
2eilC-3d62A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3d62 3C-LIKE PROTEINASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 6 HIS A  41
ASP A 176
THR A 175
TYR A 161
 959  A 350 (-3.9A)
None
None
None
 1.43A 2eimN-3d62A:
undetectable
2eimP-3d62A:
undetectable		 2eimN-3d62A:
20.46
2eimP-3d62A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3d62 3C-LIKE PROTEINASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 6 HIS A  41
ASP A 176
THR A 175
TYR A 161
 959  A 350 (-3.9A)
None
None
None
 1.45A 2einA-3d62A:
undetectable
2einC-3d62A:
undetectable		 2einA-3d62A:
20.46
2einC-3d62A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 3d62 3C-LIKE PROTEINASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 8 SER A 144
TYR A 161
HIS A 172
HIS A 163
 959  A 350 ( 4.4A)
None
None
None
 1.39A 2v0gA-3d62A:
undetectable		 2v0gA-3d62A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3d62 3C-LIKE PROTEINASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 7 HIS A  41
ASP A 176
THR A 175
TYR A 161
 959  A 350 (-3.9A)
None
None
None
 1.38A 3ag3N-3d62A:
undetectable
3ag3P-3d62A:
undetectable		 3ag3N-3d62A:
20.46
3ag3P-3d62A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 3d62 3C-LIKE PROTEINASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		3 / 3 TYR A 126
TYR A 161
GLY A 138
 None
 0.48A 3eteB-3d62A:
undetectable
3eteD-3d62A:
undetectable
3eteF-3d62A:
undetectable		 3eteB-3d62A:
19.21
3eteD-3d62A:
19.21
3eteF-3d62A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3d62 3C-LIKE PROTEINASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 9 LEU A 205
LEU A 220
ILE A 259
ALA A 260
ALA A 267
 None
 1.04A 3mdvA-3d62A:
undetectable		 3mdvA-3d62A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 3d62 3C-LIKE PROTEINASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 12 LEU A 202
ASN A 203
LEU A 205
ALA A 206
THR A 111
 None
 1.29A 4fn9B-3d62A:
undetectable		 4fn9B-3d62A:
21.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 3d62 3C-LIKE PROTEINASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 4 THR A  25
LEU A  27
HIS A  41
GLY A 143
 None
959  A 350 ( 4.8A)
959  A 350 (-3.9A)
959  A 350 (-3.2A)
 0.40A 5gwyA-3d62A:
38.6		 5gwyA-3d62A:
42.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 3d62 3C-LIKE PROTEINASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		3 / 3 GLN A 127
THR A 111
ASP A 295
 None
 0.87A 5k9dA-3d62A:
undetectable		 5k9dA-3d62A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 3d62 3C-LIKE PROTEINASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 5 GLY A 179
ARG A  40
ASP A 176
GLN A 107
 None
 1.27A 5ubbA-3d62A:
undetectable		 5ubbA-3d62A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 3d62 3C-LIKE PROTEINASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 5 THR A 243
GLU A 240
THR A 199
LEU A 268
 None
 1.10A 5utuH-3d62A:
undetectable		 5utuH-3d62A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 3d62 3C-LIKE PROTEINASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		3 / 3 TYR A  54
HIS A  41
MET A 165
 None
959  A 350 (-3.9A)
959  A 350 (-4.4A)
 1.02A 6af6A-3d62A:
undetectable		 6af6A-3d62A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 3d62 3C-LIKE PROTEINASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		5 / 12 LEU A 272
VAL A 204
LEU A 205
VAL A 233
ALA A 234
 None
 0.76A 6ajiA-3d62A:
undetectable		 6ajiA-3d62A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3d62 3C-LIKE PROTEINASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 7 HIS A  41
ASP A 176
THR A 175
TYR A 161
 959  A 350 (-3.9A)
None
None
None
 1.35A 6nmfN-3d62A:
undetectable
6nmfP-3d62A:
undetectable		 6nmfN-3d62A:
20.46
6nmfP-3d62A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3d62 3C-LIKE PROTEINASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 6 HIS A  41
ASP A 176
THR A 175
TYR A 161
 959  A 350 (-3.9A)
None
None
None
 1.42A 6nmpA-3d62A:
undetectable
6nmpC-3d62A:
undetectable		 6nmpA-3d62A:
20.46
6nmpC-3d62A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3d62 3C-LIKE PROTEINASE
(Severe
acute
respiratory
syndrome-related
coronavirus) 		4 / 7 HIS A  41
ASP A 176
THR A 175
TYR A 161
 959  A 350 (-3.9A)
None
None
None
 1.41A 6nmpN-3d62A:
undetectable
6nmpP-3d62A:
undetectable		 6nmpN-3d62A:
20.46
6nmpP-3d62A:
21.54