SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d6b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		4 / 7 TYR A 373
VAL A 369
ILE A 210
GLY A 215
 None
 0.76A 11gsA-3d6bA:
1.5		 11gsA-3d6bA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		5 / 10 MET A 299
ALA A 338
LEU A 367
LEU A 364
ILE A 271
 None
 1.40A 1a52A-3d6bA:
undetectable		 1a52A-3d6bA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		5 / 10 MET A 299
ALA A 338
LEU A 367
LEU A 364
ILE A 271
 None
 1.39A 1a52B-3d6bA:
undetectable		 1a52B-3d6bA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		5 / 9 MET A 299
ALA A 338
LEU A 367
LEU A 364
ILE A 271
 None
 1.39A 1ereA-3d6bA:
undetectable		 1ereA-3d6bA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		5 / 9 MET A 299
ALA A 338
LEU A 367
LEU A 364
ILE A 271
 None
 1.40A 1ereB-3d6bA:
undetectable		 1ereB-3d6bA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		5 / 9 MET A 299
ALA A 338
LEU A 367
LEU A 364
ILE A 271
 None
 1.39A 1ereC-3d6bA:
undetectable		 1ereC-3d6bA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		5 / 9 MET A 299
ALA A 338
LEU A 367
LEU A 364
ILE A 271
 None
 1.38A 1ereD-3d6bA:
undetectable		 1ereD-3d6bA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		3 / 4 LYS A 184
ALA A 183
MET A 150
 None
 1.05A 1hk3A-3d6bA:
undetectable		 1hk3A-3d6bA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		3 / 3 GLU A  88
HIS A  30
ASP A  15
 None
 0.64A 1i9gA-3d6bA:
undetectable		 1i9gA-3d6bA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		4 / 6 GLY A 314
ASP A 318
TYR A 255
TRP A 259
 None
 0.92A 1kf6M-3d6bA:
undetectable
1kf6N-3d6bA:
undetectable		 1kf6M-3d6bA:
20.33
1kf6N-3d6bA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		4 / 7 PHE A 179
ALA A 207
ILE A 133
ILE A 220
 None
 0.96A 1oniD-3d6bA:
undetectable
1oniF-3d6bA:
undetectable		 1oniD-3d6bA:
16.92
1oniF-3d6bA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		4 / 6 LEU A  12
GLN A 300
GLU A 302
ILE A 303
 None
 1.01A 2fcnA-3d6bA:
undetectable
2fcnB-3d6bA:
undetectable		 2fcnA-3d6bA:
14.04
2fcnB-3d6bA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		4 / 8 TYR A 373
VAL A 369
ILE A 210
GLY A 215
 None
 0.77A 2gssA-3d6bA:
2.1		 2gssA-3d6bA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		4 / 8 TYR A 373
VAL A 369
ILE A 210
GLY A 215
 None
 0.77A 2gssB-3d6bA:
2.1		 2gssB-3d6bA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		4 / 8 SER A 334
VAL A  80
GLY A 314
TRP A 259
 None
 1.14A 2qd3A-3d6bA:
undetectable		 2qd3A-3d6bA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		4 / 7 LEU A 185
PHE A 196
GLU A 233
PRO A 238
 None
 0.91A 2vq5B-3d6bA:
undetectable		 2vq5B-3d6bA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		4 / 7 TYR A 373
VAL A 369
ILE A 210
GLY A 215
 None
 0.77A 3gssA-3d6bA:
1.4		 3gssA-3d6bA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		4 / 7 TYR A 373
VAL A 369
ILE A 210
GLY A 215
 None
 0.78A 3gssB-3d6bA:
1.4		 3gssB-3d6bA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		4 / 8 TYR A 373
VAL A 369
ILE A 210
GLY A 215
 None
 0.79A 3hjoA-3d6bA:
2.1		 3hjoA-3d6bA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		4 / 8 TYR A 373
VAL A 369
ILE A 210
GLY A 215
 None
 0.71A 3n9jA-3d6bA:
2.1		 3n9jA-3d6bA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		4 / 8 TYR A 373
VAL A 369
ILE A 210
GLY A 215
 None
 0.77A 3n9jB-3d6bA:
2.4		 3n9jB-3d6bA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		5 / 10 LEU A 349
ALA A 361
PHE A 358
GLY A 359
ILE A 271
 None
 1.35A 3qpsA-3d6bA:
2.1		 3qpsA-3d6bA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		4 / 7 GLU A  57
TYR A  32
HIS A  30
VAL A  25
 None
 1.07A 4a97D-3d6bA:
3.6		 4a97D-3d6bA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		4 / 7 ALA A 176
ASP A 177
VAL A 107
ILE A  54
 None
 0.98A 4eyrA-3d6bA:
undetectable		 4eyrA-3d6bA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		5 / 12 LEU A 349
GLY A 353
PHE A  45
ILE A 271
ARG A 217
 None
 1.14A 4hytA-3d6bA:
undetectable		 4hytA-3d6bA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		5 / 12 LEU A 349
GLY A 353
PHE A  45
ILE A 271
ARG A 217
 None
 1.14A 4hytC-3d6bA:
undetectable		 4hytC-3d6bA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		3 / 3 ARG A 153
LYS A 150
LYS A 184
 None
 1.19A 4k50A-3d6bA:
undetectable		 4k50A-3d6bA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		4 / 6 TYR A  96
GLU A  57
TYR A  32
LEU A  63
 None
 1.31A 4twdF-3d6bA:
1.2
4twdG-3d6bA:
undetectable		 4twdF-3d6bA:
20.19
4twdG-3d6bA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		4 / 6 TYR A  96
GLU A  57
TYR A  32
LEU A  63
 None
 1.17A 4twdI-3d6bA:
undetectable
4twdJ-3d6bA:
2.0		 4twdI-3d6bA:
20.19
4twdJ-3d6bA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		3 / 3 GLU A  88
HIS A  30
ASP A  15
 None
 0.69A 5c0oG-3d6bA:
undetectable		 5c0oG-3d6bA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		5 / 12 PRO A  75
SER A 104
ASP A 318
ASP A  78
LEU A  77
 None
 1.45A 5eeiB-3d6bA:
undetectable		 5eeiB-3d6bA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		5 / 12 PRO A  75
SER A 104
ASP A 318
ASP A  78
LEU A  77
 None
 1.48A 5ef8B-3d6bA:
undetectable		 5ef8B-3d6bA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		3 / 3 HIS A 270
SER A 267
ARG A  87
 None
 0.81A 5u63A-3d6bA:
undetectable		 5u63A-3d6bA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 3d6b GLUTARYL-COA
DEHYDROGENASE
(Burkholderia
pseudomallei) 		3 / 3 VAL A 370
TYR A 373
GLU A  90
 None
 0.84A 5zmqD-3d6bA:
undetectable
5zmqE-3d6bA:
undetectable		 5zmqD-3d6bA:
20.65
5zmqE-3d6bA:
12.23