SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d6e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 3d6e BETA-GLUCANASE
(Bacillus
licheniformis) 		5 / 12 ALA A  77
TYR A  79
GLU A  92
ASP A  94
GLU A  96
 None
 0.47A 1dy4A-3d6eA:
10.7		 1dy4A-3d6eA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3d6e BETA-GLUCANASE
(Bacillus
licheniformis) 		5 / 12 PHE A  97
PHE A 107
ALA A  69
ALA A 135
MET A  66
 None
 1.00A 2x2nA-3d6eA:
undetectable		 2x2nA-3d6eA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3d6e BETA-GLUCANASE
(Bacillus
licheniformis) 		5 / 12 PHE A  97
PHE A 107
ALA A  69
ALA A 135
MET A  66
 None
 0.99A 2x2nB-3d6eA:
undetectable		 2x2nB-3d6eA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 3d6e BETA-GLUCANASE
(Bacillus
licheniformis) 		5 / 10 ALA A 135
VAL A  64
TYR A  79
ILE A  95
ILE A 166
 None
 1.03A 3retA-3d6eA:
undetectable
3retB-3d6eA:
undetectable		 3retA-3d6eA:
19.54
3retB-3d6eA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3d6e BETA-GLUCANASE
(Bacillus
licheniformis) 		4 / 7 GLU A  33
PHE A  10
TYR A 131
HIS A 132
 None
 1.04A 4a97A-3d6eA:
undetectable		 4a97A-3d6eA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3d6e BETA-GLUCANASE
(Bacillus
licheniformis) 		4 / 7 GLU A  33
PHE A  10
TYR A 131
HIS A 132
 None
 1.06A 4a97D-3d6eA:
undetectable		 4a97D-3d6eA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3d6e BETA-GLUCANASE
(Bacillus
licheniformis) 		4 / 6 GLU A  33
PHE A  10
TYR A 131
HIS A 132
 None
 1.04A 4a97E-3d6eA:
undetectable		 4a97E-3d6eA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3d6e BETA-GLUCANASE
(Bacillus
licheniformis) 		4 / 5 GLU A  33
PHE A  10
TYR A 131
HIS A 132
 None
 0.99A 4a97J-3d6eA:
undetectable		 4a97J-3d6eA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IPM_A_ACTA503_0
(GH7 FAMILY PROTEIN)		 3d6e BETA-GLUCANASE
(Bacillus
licheniformis) 		6 / 9 ALA A  77
TYR A  79
GLU A  92
ASP A  94
GLU A  96
TRP A 171
 None
 0.68A 4ipmA-3d6eA:
10.7		 4ipmA-3d6eA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3d6e BETA-GLUCANASE
(Bacillus
licheniformis) 		3 / 3 PHE A 136
ILE A  95
ASP A 148
 None
 0.66A 5cswA-3d6eA:
undetectable		 5cswA-3d6eA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 3d6e BETA-GLUCANASE
(Bacillus
licheniformis) 		5 / 12 THR A  85
PRO A 160
TRP A 138
ILE A 159
VAL A  54
 None
 1.50A 5dlvB-3d6eA:
undetectable		 5dlvB-3d6eA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 3d6e BETA-GLUCANASE
(Bacillus
licheniformis) 		5 / 12 GLY A  50
MET A 168
VAL A  26
THR A  15
GLY A  16
 None
 1.02A 6brdC-3d6eA:
undetectable		 6brdC-3d6eA:
19.25