SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d6k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		4 / 8 LYS A  15
LEU A 413
ALA A 416
LEU A 417
 None
 0.82A 1hwiD-3d6kA:
undetectable		 1hwiD-3d6kA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		5 / 11 VAL A 191
GLY A 190
GLY A 161
HIS A 141
PHE A 193
 None
 1.38A 1iolA-3d6kA:
undetectable		 1iolA-3d6kA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		5 / 11 PHE A 249
TRP A  82
ALA A  83
LEU A  88
ALA A 267
 None
 1.25A 1jb0B-3d6kA:
undetectable		 1jb0B-3d6kA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		5 / 12 LEU A 290
ASN A 291
LEU A 293
ALA A 294
GLN A 297
 None
 0.74A 2aa6A-3d6kA:
undetectable		 2aa6A-3d6kA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		3 / 3 ASP A 163
VAL A 135
PRO A 384
 None
 0.77A 2avvA-3d6kA:
undetectable		 2avvA-3d6kA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		5 / 9 LEU A 363
VAL A 360
THR A 356
VAL A 336
VAL A 352
 None
 1.33A 2l8mA-3d6kA:
undetectable		 2l8mA-3d6kA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		5 / 11 ILE A 348
LEU A 327
ILE A 326
PRO A 393
LEU A 401
 None
 1.21A 3a51A-3d6kA:
undetectable		 3a51A-3d6kA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		5 / 12 ILE A 348
LEU A 327
ILE A 326
PRO A 393
LEU A 401
 None
 1.21A 3a51D-3d6kA:
undetectable		 3a51D-3d6kA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		5 / 10 PHE A 249
TRP A  82
ALA A  83
LEU A  88
ALA A 267
 None
 1.27A 3lw5B-3d6kA:
undetectable		 3lw5B-3d6kA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		5 / 11 PHE A 249
TRP A  82
ALA A  83
LEU A  88
ALA A 267
 None
 1.25A 3pcqB-3d6kA:
undetectable		 3pcqB-3d6kA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		5 / 12 SER A 349
PRO A 136
GLY A 137
LEU A  34
ASP A  33
 None
 1.45A 3r24A-3d6kA:
2.6		 3r24A-3d6kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		5 / 12 ASP A 118
ARG A 212
PHE A 211
THR A 197
ALA A 202
 CL  A 421 ( 4.2A)
None
None
None
None
 1.31A 3ua1A-3d6kA:
undetectable		 3ua1A-3d6kA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		4 / 7 LEU A  50
ILE A  78
THR A 253
GLY A 262
 None
 0.90A 4eq4A-3d6kA:
undetectable		 4eq4A-3d6kA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		4 / 7 LEU A  50
ILE A  78
THR A 253
GLY A 262
 None
 0.91A 4eqlA-3d6kA:
undetectable		 4eqlA-3d6kA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		4 / 7 LEU A  50
ILE A  78
THR A 253
GLY A 262
 None
 0.90A 4eqlB-3d6kA:
undetectable		 4eqlB-3d6kA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		3 / 3 GLU A 160
ASP A 159
ASP A 163
 None
 0.75A 4gc9A-3d6kA:
undetectable		 4gc9A-3d6kA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		4 / 6 LEU A  50
ILE A  78
THR A 253
GLY A 262
 None
 0.96A 4l39A-3d6kA:
undetectable		 4l39A-3d6kA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		4 / 7 LEU A  50
ILE A  78
THR A 253
GLY A 262
 None
 0.91A 4l39B-3d6kA:
undetectable		 4l39B-3d6kA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		5 / 12 LEU A 290
ASN A 291
LEU A 293
ALA A 294
GLN A 297
 None
 0.76A 4ltwA-3d6kA:
undetectable		 4ltwA-3d6kA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		4 / 7 HIS A 141
VAL A 214
ILE A 108
ILE A 144
 None
 0.77A 4lv9A-3d6kA:
undetectable		 4lv9A-3d6kA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		4 / 7 HIS A 141
VAL A 214
ILE A 108
ILE A 144
 None
 0.74A 4lv9B-3d6kA:
2.6		 4lv9B-3d6kA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		5 / 11 LEU A 331
LEU A 327
LEU A  32
LEU A  25
LEU A  30
 None
 1.05A 4zowA-3d6kA:
undetectable		 4zowA-3d6kA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		3 / 3 ASP A 139
ARG A 140
TYR A 138
 None
None
EDO  A 422 (-3.9A)
 1.02A 5a7mA-3d6kA:
4.2		 5a7mA-3d6kA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		3 / 3 ASP A 139
ARG A 140
TYR A 138
 None
None
EDO  A 422 (-3.9A)
 0.99A 5a7mB-3d6kA:
4.1		 5a7mB-3d6kA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		5 / 12 ALA A  95
GLY A  74
GLY A 286
LYS A  61
LEU A 293
 None
 0.79A 5c0oG-3d6kA:
4.4		 5c0oG-3d6kA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		4 / 6 HIS A 308
ALA A  85
LEU A  86
TYR A 219
 None
None
None
EDO  A 422 (-4.5A)
 0.98A 5igiA-3d6kA:
undetectable		 5igiA-3d6kA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		5 / 9 LEU A 331
ILE A 326
ILE A 389
GLU A 387
VAL A 353
 None
 1.43A 5igzA-3d6kA:
undetectable		 5igzA-3d6kA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		4 / 5 SER A 358
VAL A 361
GLY A 373
ALA A 374
 None
 1.06A 5k50A-3d6kA:
undetectable		 5k50A-3d6kA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_B_PQNB1844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		5 / 10 PHE A 249
TRP A  82
ALA A  83
LEU A  88
ALA A 267
 None
 1.27A 5oy0b-3d6kA:
undetectable		 5oy0b-3d6kA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		5 / 12 ASP A 159
LEU A  34
ILE A 326
PHE A 408
ALA A 409
 None
 1.15A 5vc0A-3d6kA:
undetectable		 5vc0A-3d6kA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		4 / 8 PRO A 342
THR A 189
THR A 340
TRP A 215
 None
 1.36A 5x2sI-3d6kA:
undetectable
5x2sJ-3d6kA:
undetectable
5x2sK-3d6kA:
undetectable		 5x2sI-3d6kA:
18.42
5x2sJ-3d6kA:
17.26
5x2sK-3d6kA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3d6k PUTATIVE
AMINOTRANSFERASE
(Corynebacterium
diphtheriae) 		5 / 12 ILE A 213
ASN A 217
THR A 197
LEU A 201
PHE A 193
 None
 1.23A 5xxiA-3d6kA:
undetectable		 5xxiA-3d6kA:
22.61