SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d6s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 3d6s ALLERGEN DER F I
(Dermatophagoides
farinae) 		5 / 12 ILE A  77
THR A  22
VAL A  23
LEU A 132
ILE A 175
 None
 1.27A 1kqwA-3d6sA:
undetectable		 1kqwA-3d6sA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 3d6s ALLERGEN DER F I
(Dermatophagoides
farinae) 		3 / 3 ARG A 190
ARG A  21
ARG A  27
 None
 1.09A 1l7hA-3d6sA:
undetectable		 1l7hA-3d6sA:
22.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 3d6s ALLERGEN DER F I
(Dermatophagoides
farinae) 		7 / 10 GLN A  29
GLY A  33
SER A  34
PHE A  38
SER A  39
ALA A 172
GLY A  74
 None
 1.24A 1stfE-3d6sA:
29.6
1stfI-3d6sA:
undetectable		 1stfE-3d6sA:
32.17
1stfI-3d6sA:
17.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 3d6s ALLERGEN DER F I
(Dermatophagoides
farinae) 		8 / 10 GLN A  29
GLY A  33
SER A  34
TRP A  36
PHE A  38
SER A  39
HIS A 171
ALA A 172
 None
 0.30A 1stfE-3d6sA:
29.6
1stfI-3d6sA:
undetectable		 1stfE-3d6sA:
32.17
1stfI-3d6sA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 3d6s ALLERGEN DER F I
(Dermatophagoides
farinae) 		4 / 6 PRO A  12
ASP A 184
ASP A 185
TYR A 178
 None
 1.39A 2lh8A-3d6sA:
undetectable		 2lh8A-3d6sA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 3d6s ALLERGEN DER F I
(Dermatophagoides
farinae) 		4 / 7 GLN A  29
GLY A  33
HIS A 171
TRP A 193
 None
 0.41A 3ai8A-3d6sA:
27.9		 3ai8A-3d6sA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 3d6s ALLERGEN DER F I
(Dermatophagoides
farinae) 		4 / 5 GLY A 198
ASP A 199
ARG A 157
GLN A 161
 None
 1.36A 3qx3A-3d6sA:
undetectable		 3qx3A-3d6sA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_2
(PROTEASE)		 3d6s ALLERGEN DER F I
(Dermatophagoides
farinae) 		5 / 10 ALA A 140
ILE A  81
VAL A 221
ILE A 120
ILE A  77
 None
 1.00A 3s43B-3d6sA:
undetectable		 3s43B-3d6sA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3d6s ALLERGEN DER F I
(Dermatophagoides
farinae) 		4 / 8 ALA A 140
ALA A 172
SER A 192
ALA A  43
 None
 0.80A 4twdF-3d6sA:
undetectable
4twdG-3d6sA:
undetectable
4twdH-3d6sA:
undetectable
4twdI-3d6sA:
undetectable
4twdJ-3d6sA:
undetectable		 4twdF-3d6sA:
19.48
4twdG-3d6sA:
19.48
4twdH-3d6sA:
19.48
4twdI-3d6sA:
19.48
4twdJ-3d6sA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3d6s ALLERGEN DER F I
(Dermatophagoides
farinae) 		4 / 6 ARG A 100
ARG A 105
ARG A 103
ASP A  65
 SO4  A 225 ( 4.3A)
SO4  A 225 (-4.1A)
None
None
 1.30A 4xqeB-3d6sA:
undetectable		 4xqeB-3d6sA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 3d6s ALLERGEN DER F I
(Dermatophagoides
farinae) 		4 / 8 LEU A 132
ASN A 174
VAL A 189
GLU A 215
 None
 0.88A 4zbqA-3d6sA:
undetectable		 4zbqA-3d6sA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3d6s ALLERGEN DER F I
(Dermatophagoides
farinae) 		4 / 6 GLY A 177
LEU A  20
ARG A  18
VAL A  23
 None
 0.91A 5x80A-3d6sA:
undetectable
5x80B-3d6sA:
undetectable		 5x80A-3d6sA:
19.31
5x80B-3d6sA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3d6s ALLERGEN DER F I
(Dermatophagoides
farinae) 		3 / 3 GLN A  85
TYR A 117
ASN A 116
 None
 0.70A 6dwdC-3d6sA:
undetectable		 6dwdC-3d6sA:
18.36