SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d7a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 3d7a UPF0201 PROTEIN
PH1010
(Pyrococcus
horikoshii) 		5 / 12 LEU A  57
LEU A  60
LEU A  63
GLN A  67
LEU A  77
 None
 1.35A 1a28B-3d7aA:
undetectable		 1a28B-3d7aA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 3d7a UPF0201 PROTEIN
PH1010
(Pyrococcus
horikoshii) 		5 / 12 LEU A  57
LEU A  60
LEU A  63
GLN A  67
LEU A  77
 None
 1.18A 1sqnA-3d7aA:
undetectable		 1sqnA-3d7aA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 3d7a UPF0201 PROTEIN
PH1010
(Pyrococcus
horikoshii) 		5 / 12 LEU A  57
LEU A  60
LEU A  63
GLN A  67
LEU A  77
 None
 1.16A 2w8yB-3d7aA:
undetectable		 2w8yB-3d7aA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 3d7a UPF0201 PROTEIN
PH1010
(Pyrococcus
horikoshii) 		5 / 12 LEU A  57
LEU A  60
LEU A  63
GLN A  67
LEU A  77
 None
 1.26A 3d90A-3d7aA:
undetectable		 3d90A-3d7aA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3d7a UPF0201 PROTEIN
PH1010
(Pyrococcus
horikoshii) 		4 / 8 THR A  51
LEU A  34
VAL A  10
VAL A   8
 None
 0.93A 4em2A-3d7aA:
undetectable		 4em2A-3d7aA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 3d7a UPF0201 PROTEIN
PH1010
(Pyrococcus
horikoshii) 		3 / 3 PHE A  39
VAL A  48
GLU A   9
 None
 0.78A 4fvqA-3d7aA:
undetectable		 4fvqA-3d7aA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 3d7a UPF0201 PROTEIN
PH1010
(Pyrococcus
horikoshii) 		3 / 3 ILE A 137
MET A 124
ASP A  71
 None
 0.65A 5h2uA-3d7aA:
undetectable		 5h2uA-3d7aA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3d7a UPF0201 PROTEIN
PH1010
(Pyrococcus
horikoshii) 		3 / 3 ALA A  26
ASN A  29
LEU A  30
 None
 0.29A 5i1nB-3d7aA:
undetectable		 5i1nB-3d7aA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3d7a UPF0201 PROTEIN
PH1010
(Pyrococcus
horikoshii) 		3 / 3 ALA A  26
ASN A  29
LEU A  30
 None
 0.35A 5i1oA-3d7aA:
undetectable		 5i1oA-3d7aA:
12.50