SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d7n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3d7n FLAVODOXIN,
WRBA-LIKE PROTEIN
(Agrobacterium
fabrum) 		5 / 12 ILE A  38
LEU A 114
PHE A  76
ILE A  58
LEU A  52
 None
 1.03A 1drfA-3d7nA:
undetectable		 1drfA-3d7nA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 3d7n FLAVODOXIN,
WRBA-LIKE PROTEIN
(Agrobacterium
fabrum) 		5 / 12 ALA A  77
LEU A  52
ILE A  59
GLY A  95
LEU A 114
 None
 1.00A 1qknA-3d7nA:
undetectable		 1qknA-3d7nA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 3d7n FLAVODOXIN,
WRBA-LIKE PROTEIN
(Agrobacterium
fabrum) 		5 / 12 GLY A  96
GLY A  61
ALA A  24
TYR A 176
PHE A  94
 None
 1.13A 1ri4A-3d7nA:
undetectable		 1ri4A-3d7nA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 3d7n FLAVODOXIN,
WRBA-LIKE PROTEIN
(Agrobacterium
fabrum) 		5 / 12 ILE A  38
LEU A 114
PHE A  76
ILE A  58
LEU A  52
 None
 1.07A 2w3bA-3d7nA:
undetectable		 2w3bA-3d7nA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 3d7n FLAVODOXIN,
WRBA-LIKE PROTEIN
(Agrobacterium
fabrum) 		5 / 12 ILE A  38
LEU A 114
PHE A  76
ILE A  58
LEU A  52
 None
 1.06A 2w3bB-3d7nA:
undetectable		 2w3bB-3d7nA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 3d7n FLAVODOXIN,
WRBA-LIKE PROTEIN
(Agrobacterium
fabrum) 		5 / 12 ILE A  38
LEU A 114
PHE A  76
ILE A  58
LEU A  52
 None
 1.08A 2w3mA-3d7nA:
undetectable		 2w3mA-3d7nA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 3d7n FLAVODOXIN,
WRBA-LIKE PROTEIN
(Agrobacterium
fabrum) 		5 / 12 ALA A  77
LEU A  52
ILE A  59
GLY A  95
LEU A 114
 None
 1.05A 3q95A-3d7nA:
undetectable		 3q95A-3d7nA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3d7n FLAVODOXIN,
WRBA-LIKE PROTEIN
(Agrobacterium
fabrum) 		5 / 12 ILE A  38
LEU A 114
PHE A  76
ILE A  58
LEU A  52
 None
 1.08A 4kebB-3d7nA:
undetectable		 4kebB-3d7nA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3d7n FLAVODOXIN,
WRBA-LIKE PROTEIN
(Agrobacterium
fabrum) 		5 / 12 ILE A  38
LEU A 114
PHE A  76
ILE A  58
LEU A  52
 None
 1.07A 4kfjB-3d7nA:
undetectable		 4kfjB-3d7nA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3d7n FLAVODOXIN,
WRBA-LIKE PROTEIN
(Agrobacterium
fabrum) 		5 / 12 ILE A  38
LEU A 114
PHE A  76
ILE A  58
LEU A  52
 None
 1.06A 4m6kA-3d7nA:
undetectable		 4m6kA-3d7nA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 3d7n FLAVODOXIN,
WRBA-LIKE PROTEIN
(Agrobacterium
fabrum) 		4 / 7 THR A  20
PHE A  73
SER A  70
HIS A  14
 None
 1.14A 4o4dA-3d7nA:
undetectable		 4o4dA-3d7nA:
19.69