SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d7r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 3d7r ESTERASE
(Staphylococcus
aureus) 		4 / 7 GLU A  57
LEU A  56
VAL A  52
LEU A 104
 None
 0.92A 1hk3A-3d7rA:
undetectable		 1hk3A-3d7rA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 3d7r ESTERASE
(Staphylococcus
aureus) 		5 / 12 GLY A 152
GLY A 154
LEU A 157
LEU A  98
HIS A  95
 None
None
None
DMS  A1417 (-3.9A)
None
 1.01A 1ya4C-3d7rA:
15.2		 1ya4C-3d7rA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 3d7r ESTERASE
(Staphylococcus
aureus) 		3 / 3 ASP A 299
VAL A 302
PRO A 237
 None
 0.79A 2avvA-3d7rA:
undetectable		 2avvA-3d7rA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 3d7r ESTERASE
(Staphylococcus
aureus) 		5 / 12 LEU A 178
ILE A  82
ALA A 158
VAL A 239
MET A 260
 None
 0.98A 2g78A-3d7rA:
undetectable		 2g78A-3d7rA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3d7r ESTERASE
(Staphylococcus
aureus) 		5 / 12 LEU A 221
ALA A 156
ASN A  87
SER A 204
GLY A 207
 None
None
None
CL  A1100 ( 4.7A)
None
 1.06A 2vmyA-3d7rA:
undetectable		 2vmyA-3d7rA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 3d7r ESTERASE
(Staphylococcus
aureus) 		5 / 11 LEU A 219
ASP A 223
ASP A 184
ILE A 123
ILE A 226
 DMS  A1416 ( 4.4A)
None
None
DMS  A1416 (-4.8A)
None
 1.14A 3ebzA-3d7rA:
undetectable		 3ebzA-3d7rA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 3d7r ESTERASE
(Staphylococcus
aureus) 		3 / 3 SER A 188
ASP A 184
ASN A 230
 None
 0.83A 3lsfB-3d7rA:
undetectable
3lsfE-3d7rA:
undetectable		 3lsfB-3d7rA:
18.60
3lsfE-3d7rA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 3d7r ESTERASE
(Staphylococcus
aureus) 		3 / 3 ASP A 184
ASN A 230
SER A 188
 None
 0.86A 3lsfB-3d7rA:
undetectable
3lsfE-3d7rA:
undetectable		 3lsfB-3d7rA:
18.60
3lsfE-3d7rA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7r ESTERASE
(Staphylococcus
aureus) 		4 / 5 VAL A 202
ILE A 182
MET A 149
ARG A 246
 DMS  A1402 ( 4.5A)
None
None
None
 1.35A 3oezA-3d7rA:
undetectable		 3oezA-3d7rA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3d7r ESTERASE
(Staphylococcus
aureus) 		5 / 12 SER A 160
LEU A 183
ILE A 233
MET A 260
MET A 241
 None
 1.42A 3qt0A-3d7rA:
undetectable		 3qt0A-3d7rA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3d7r ESTERASE
(Staphylococcus
aureus) 		5 / 12 LEU A 176
ILE A 130
GLY A 154
ALA A 156
LEU A 183
 None
 1.20A 3uj7B-3d7rA:
2.8		 3uj7B-3d7rA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 3d7r ESTERASE
(Staphylococcus
aureus) 		3 / 3 ASP A 252
TRP A 215
SER A 188
 None
 0.91A 4lrhA-3d7rA:
undetectable		 4lrhA-3d7rA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3d7r ESTERASE
(Staphylococcus
aureus) 		4 / 8 ILE A 281
TYR A 282
GLY A 152
LEU A 203
 DMS  A1407 (-4.9A)
DMS  A1407 ( 4.2A)
None
None
 0.92A 5esfA-3d7rA:
undetectable		 5esfA-3d7rA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 3d7r ESTERASE
(Staphylococcus
aureus) 		4 / 8 HIS A  83
GLN A  90
TRP A  96
LEU A 112
 None
 1.09A 5hs6A-3d7rA:
2.2		 5hs6A-3d7rA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 3d7r ESTERASE
(Staphylococcus
aureus) 		3 / 3 GLN A 163
THR A 232
ASP A 167
 None
 0.84A 5k9dA-3d7rA:
2.0		 5k9dA-3d7rA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 3d7r ESTERASE
(Staphylococcus
aureus) 		5 / 12 LEU A  99
LEU A  98
GLY A 150
GLY A  85
PRO A  93
 None
DMS  A1417 (-3.9A)
None
None
DMS  A1410 (-4.7A)
 1.07A 6ce2B-3d7rA:
undetectable		 6ce2B-3d7rA:
15.09