SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d7u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 GLY A 202
VAL A 209
ALA A 220
VAL A 249
ASN A 319
LEU A 321
ASP A 332
 None
 0.78A 1fmoE-3d7uA:
24.5		 1fmoE-3d7uA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		4 / 8 TYR A 380
ILE A 379
HIS A 449
LEU A 440
 None
 0.88A 1fslA-3d7uA:
undetectable		 1fslA-3d7uA:
20.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ALA A 220
GLU A 236
MET A 240
THR A 266
GLY A 272
LEU A 321
 None
 0.51A 1iepA-3d7uA:
27.0		 1iepA-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 6 LYS A 222
VAL A 239
VAL A 249
ILE A 264
ARG A 313
 None
 1.01A 1iepA-3d7uA:
27.0		 1iepA-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 6 VAL A 239
VAL A 249
ILE A 264
MET A 269
ARG A 313
 None
 0.91A 1iepA-3d7uA:
27.0		 1iepA-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		4 / 7 ILE A 264
MET A 269
ARG A 313
LEU A 321
 None
 0.67A 1iepB-3d7uA:
27.0		 1iepB-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		4 / 7 LYS A 222
VAL A 249
ILE A 264
ARG A 313
 None
 0.87A 1iepB-3d7uA:
27.0		 1iepB-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 7 VAL A 239
VAL A 249
ILE A 264
ARG A 313
LEU A 321
 None
 0.73A 1iepB-3d7uA:
27.0		 1iepB-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 ALA A 220
LYS A 222
GLU A 236
THR A 266
MET A 269
GLY A 272
LEU A 321
 None
 0.49A 1m17A-3d7uA:
26.4		 1m17A-3d7uA:
34.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ALA A 220
GLU A 236
MET A 240
VAL A 249
THR A 266
LEU A 321
 None
 0.56A 1opjA-3d7uA:
26.5		 1opjA-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 VAL A 209
ALA A 220
GLU A 236
MET A 240
VAL A 249
THR A 266
 None
 0.56A 1opjA-3d7uA:
26.5		 1opjA-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ALA A 220
GLU A 236
MET A 240
VAL A 249
THR A 266
GLY A 272
 None
 0.49A 1opjB-3d7uA:
26.7		 1opjB-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 VAL A 209
ALA A 220
GLU A 236
MET A 240
VAL A 249
THR A 266
 None
 0.53A 1opjB-3d7uA:
26.7		 1opjB-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 VAL A 209
ALA A 220
LYS A 222
GLU A 236
VAL A 249
THR A 266
GLY A 272
LEU A 321
 None
 0.53A 1t46A-3d7uA:
26.0		 1t46A-3d7uA:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 12 ALA A 220
GLU A 236
THR A 266
LEU A 305
HIS A 312
 None
 0.55A 1uwhA-3d7uA:
19.5		 1uwhA-3d7uA:
31.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ALA A 220
LYS A 222
GLU A 236
THR A 266
LEU A 305
HIS A 312
 None
 0.54A 1uwhB-3d7uA:
19.2		 1uwhB-3d7uA:
31.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 VAL A 209
ALA A 220
GLU A 236
THR A 266
LEU A 305
HIS A 312
 None
 0.58A 1uwjA-3d7uA:
7.7		 1uwjA-3d7uA:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 ILE A 201
VAL A 209
ALA A 220
GLU A 236
THR A 266
LEU A 305
HIS A 312
 None
 0.61A 1uwjB-3d7uA:
27.7		 1uwjB-3d7uA:
31.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		3 / 3 ARG A 430
SER A 381
TYR A 380
 None
 0.51A 1x70A-3d7uA:
2.6		 1x70A-3d7uA:
16.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ALA A 220
THR A 266
GLY A 272
ASP A 276
ARG A 279
LEU A 321
 None
 0.59A 1xkkA-3d7uA:
25.6		 1xkkA-3d7uA:
32.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 THR A 266
GLY A 272
ASP A 276
ARG A 279
LEU A 321
ASP A 332
 None
 0.57A 1xkkA-3d7uA:
25.6		 1xkkA-3d7uA:
32.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 ILE A 201
VAL A 209
LYS A 222
VAL A 249
ASN A 319
LEU A 321
ASP A 332
 None
 0.81A 2eufB-3d7uA:
26.3		 2eufB-3d7uA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 11 GLY A 202
VAL A 209
ALA A 220
TYR A 268
SER A 273
LEU A 321
 None
 0.54A 2evaA-3d7uA:
28.1		 2evaA-3d7uA:
28.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		9 / 12 ALA A 220
LYS A 222
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
GLY A 272
LEU A 321
 None
 0.74A 2gqgA-3d7uA:
28.1		 2gqgA-3d7uA:
43.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		9 / 12 VAL A 209
ALA A 220
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
GLY A 272
LEU A 321
 None
 0.46A 2gqgB-3d7uA:
34.7		 2gqgB-3d7uA:
43.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ALA A 220
GLU A 236
MET A 240
THR A 266
GLY A 272
LEU A 321
 None
 0.54A 2hyyA-3d7uA:
31.9		 2hyyA-3d7uA:
44.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 VAL A 209
ALA A 220
GLU A 236
MET A 240
THR A 266
LEU A 321
 None
 0.78A 2hyyA-3d7uA:
31.9		 2hyyA-3d7uA:
44.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 6 LYS A 222
VAL A 239
VAL A 249
ILE A 264
ARG A 313
 None
 1.03A 2hyyA-3d7uA:
31.9		 2hyyA-3d7uA:
44.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ALA A 220
GLU A 236
MET A 240
THR A 266
GLY A 272
LEU A 321
 None
 0.49A 2hyyB-3d7uA:
31.8		 2hyyB-3d7uA:
44.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		4 / 6 LYS A 222
VAL A 239
VAL A 249
ILE A 264
 None
 0.63A 2hyyB-3d7uA:
31.8		 2hyyB-3d7uA:
44.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 VAL A 209
ALA A 220
GLU A 236
VAL A 249
THR A 266
GLY A 272
LEU A 321
 None
 0.66A 2hyyC-3d7uA:
27.3		 2hyyC-3d7uA:
44.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		4 / 6 LYS A 222
VAL A 239
MET A 240
ILE A 264
 None
 0.45A 2hyyC-3d7uA:
27.3		 2hyyC-3d7uA:
44.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		4 / 6 VAL A 239
MET A 240
ILE A 264
MET A 269
 None
 0.58A 2hyyC-3d7uA:
27.3		 2hyyC-3d7uA:
44.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ALA A 220
GLU A 236
MET A 240
ILE A 264
THR A 266
LEU A 321
 None
 0.56A 2hyyD-3d7uA:
27.0		 2hyyD-3d7uA:
44.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 VAL A 209
ALA A 220
GLU A 236
MET A 240
ILE A 264
THR A 266
 None
 0.39A 2hyyD-3d7uA:
27.0		 2hyyD-3d7uA:
44.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 ALA A 220
LYS A 222
GLU A 236
MET A 240
THR A 266
GLY A 272
LEU A 321
 None
 0.73A 2itoA-3d7uA:
27.4		 2itoA-3d7uA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 ALA A 220
LYS A 222
GLU A 236
THR A 266
GLY A 272
ASP A 276
LEU A 321
 None
 0.76A 2itoA-3d7uA:
27.4		 2itoA-3d7uA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		10 / 12 GLY A 202
VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
THR A 266
GLY A 272
LEU A 321
ASP A 332
 None
 0.80A 2ityA-3d7uA:
27.1		 2ityA-3d7uA:
35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 VAL A 209
ALA A 220
GLU A 236
THR A 266
GLY A 272
ASP A 276
LEU A 321
ASP A 332
 None
 0.78A 2itzA-3d7uA:
26.9		 2itzA-3d7uA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		9 / 12 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
THR A 266
GLY A 272
LEU A 321
ASP A 332
 None
 0.78A 2itzA-3d7uA:
26.9		 2itzA-3d7uA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		9 / 12 VAL A 209
ALA A 220
GLU A 236
MET A 240
ILE A 264
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.72A 2oiqA-3d7uA:
26.6		 2oiqA-3d7uA:
42.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
ILE A 264
THR A 266
TYR A 268
 None
 0.62A 2oiqA-3d7uA:
26.6		 2oiqA-3d7uA:
42.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		4 / 5 VAL A 239
LEU A 243
MET A 269
ARG A 313
 None
 0.97A 2oiqA-3d7uA:
26.6		 2oiqA-3d7uA:
42.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 ALA A 220
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
TYR A 268
ASP A 332
 None
 0.93A 2pl0A-3d7uA:
25.5		 2pl0A-3d7uA:
43.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 ALA A 220
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
TYR A 268
LEU A 321
 None
 0.94A 2pl0A-3d7uA:
25.5		 2pl0A-3d7uA:
43.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		9 / 12 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
TYR A 268
 None
 0.80A 2pl0A-3d7uA:
25.5		 2pl0A-3d7uA:
43.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 GLY A 202
ALA A 220
TYR A 268
MET A 269
GLY A 272
ASP A 332
 None
 0.75A 2wgjA-3d7uA:
31.3		 2wgjA-3d7uA:
37.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 GLY A 202
VAL A 209
ALA A 220
TYR A 268
MET A 269
GLY A 272
 None
 0.74A 2wgjA-3d7uA:
31.3		 2wgjA-3d7uA:
37.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 9 VAL A 209
ALA A 220
MET A 269
GLY A 272
LEU A 321
ASP A 332
 None
 0.63A 2xp2A-3d7uA:
33.2		 2xp2A-3d7uA:
34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		10 / 12 ILE A 201
ALA A 220
LYS A 222
GLU A 236
MET A 240
ILE A 264
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.78A 2y6oA-3d7uA:
29.4		 2y6oA-3d7uA:
39.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		10 / 12 ILE A 201
ALA A 220
LYS A 222
MET A 240
ILE A 264
THR A 266
TYR A 268
GLY A 272
LEU A 321
SER A 331
 None
 0.82A 2y6oA-3d7uA:
29.4		 2y6oA-3d7uA:
39.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ILE A 201
VAL A 209
ALA A 220
MET A 269
GLY A 272
LEU A 321
 None
 0.49A 2y7jA-3d7uA:
26.4		 2y7jA-3d7uA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 10 ILE A 201
VAL A 209
ALA A 220
MET A 269
GLY A 272
LEU A 321
 None
 0.53A 2y7jB-3d7uA:
26.9		 2y7jB-3d7uA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 10 ILE A 201
VAL A 209
ALA A 220
MET A 269
LEU A 321
ASP A 332
 None
 0.82A 2y7jB-3d7uA:
26.9		 2y7jB-3d7uA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 10 ILE A 201
VAL A 209
ALA A 220
MET A 269
GLY A 272
ASP A 276
LEU A 321
 None
 0.49A 2y7jC-3d7uA:
26.4		 2y7jC-3d7uA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 10 ILE A 201
VAL A 209
ALA A 220
MET A 269
GLY A 272
ASP A 276
LEU A 321
 None
 0.56A 2y7jD-3d7uA:
26.9		 2y7jD-3d7uA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 12 ALA A 316
SER A 381
PRO A 386
ALA A 407
PRO A 408
 None
 1.21A 2zifB-3d7uA:
undetectable		 2zifB-3d7uA:
22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		10 / 12 ALA A 220
LYS A 222
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
MET A 269
GLY A 272
LEU A 321
 None
 0.61A 2zvaA-3d7uA:
28.4		 2zvaA-3d7uA:
43.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 10 ALA A 220
LYS A 222
VAL A 249
MET A 269
GLY A 272
LEU A 321
 None
 0.50A 3aoxA-3d7uA:
27.1		 3aoxA-3d7uA:
33.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 VAL A 209
ALA A 220
LEU A 251
THR A 266
GLY A 272
LEU A 321
 None
 0.68A 3bbtB-3d7uA:
24.8		 3bbtB-3d7uA:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 ALA A 220
GLU A 236
MET A 240
LEU A 248
THR A 266
GLY A 272
HIS A 312
LEU A 321
 None
 0.60A 3cs9A-3d7uA:
27.0		 3cs9A-3d7uA:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 ALA A 220
GLU A 236
VAL A 239
MET A 240
THR A 266
GLY A 272
HIS A 312
LEU A 321
 None
 0.62A 3cs9A-3d7uA:
27.0		 3cs9A-3d7uA:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 ALA A 220
GLU A 236
VAL A 239
MET A 240
LEU A 248
THR A 266
GLY A 272
 None
 0.42A 3cs9B-3d7uA:
28.0		 3cs9B-3d7uA:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 ALA A 220
VAL A 239
MET A 240
LEU A 248
THR A 266
GLY A 272
HIS A 312
 None
 0.49A 3cs9B-3d7uA:
28.0		 3cs9B-3d7uA:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 9 VAL A 209
VAL A 249
ILE A 264
PHE A 310
LEU A 321
VAL A 330
 None
 0.76A 3cs9B-3d7uA:
28.0		 3cs9B-3d7uA:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 ALA A 220
GLU A 236
VAL A 239
MET A 240
LEU A 248
THR A 266
HIS A 312
 None
 0.63A 3cs9C-3d7uA:
31.9		 3cs9C-3d7uA:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 GLU A 236
VAL A 239
MET A 240
LEU A 248
THR A 266
HIS A 312
ASP A 332
 None
 1.25A 3cs9C-3d7uA:
31.9		 3cs9C-3d7uA:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 9 VAL A 209
VAL A 249
ILE A 264
MET A 269
VAL A 330
 None
 0.77A 3cs9C-3d7uA:
31.9		 3cs9C-3d7uA:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ALA A 220
GLU A 236
MET A 240
LEU A 248
THR A 266
GLY A 272
 None
 0.56A 3cs9D-3d7uA:
27.1		 3cs9D-3d7uA:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ALA A 220
GLU A 236
VAL A 239
MET A 240
THR A 266
GLY A 272
 None
 0.52A 3cs9D-3d7uA:
27.1		 3cs9D-3d7uA:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ALA A 220
MET A 240
LEU A 248
THR A 266
GLY A 272
HIS A 312
 None
 0.40A 3cs9D-3d7uA:
27.1		 3cs9D-3d7uA:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 GLY A 207
VAL A 209
ALA A 220
LYS A 222
SER A 273
ASN A 319
LEU A 321
ASP A 332
 None
 0.70A 3eygA-3d7uA:
32.2		 3eygA-3d7uA:
36.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 GLY A 207
VAL A 209
ALA A 220
LYS A 222
TYR A 268
SER A 273
LEU A 321
ASP A 332
 None
 0.80A 3fupA-3d7uA:
32.4		 3fupA-3d7uA:
35.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 11 VAL A 209
ALA A 220
VAL A 249
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.69A 3g0eA-3d7uA:
29.7		 3g0eA-3d7uA:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 10 VAL A 209
ALA A 220
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.61A 3g0fB-3d7uA:
30.8		 3g0fB-3d7uA:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		10 / 12 VAL A 209
ALA A 220
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.49A 3g5dA-3d7uA:
28.2		 3g5dA-3d7uA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		10 / 12 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
VAL A 249
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.60A 3g5dB-3d7uA:
28.1		 3g5dB-3d7uA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 VAL A 209
ALA A 220
GLU A 236
MET A 240
VAL A 249
THR A 266
LEU A 321
 None
 0.63A 3gvuA-3d7uA:
28.3		 3gvuA-3d7uA:
43.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		4 / 5 LYS A 222
VAL A 239
ILE A 264
TYR A 268
 None
 0.51A 3gvuA-3d7uA:
28.3		 3gvuA-3d7uA:
43.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		4 / 5 VAL A 239
ILE A 264
TYR A 268
MET A 269
 None
 0.65A 3gvuA-3d7uA:
28.3		 3gvuA-3d7uA:
43.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		3 / 3 ILE A 379
PHE A 382
HIS A 449
 None
 0.70A 3h0aA-3d7uA:
undetectable		 3h0aA-3d7uA:
22.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ALA A 220
GLU A 236
MET A 240
LEU A 248
HIS A 312
LEU A 321
 None
 0.61A 3ik3A-3d7uA:
31.5		 3ik3A-3d7uA:
44.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 GLU A 236
MET A 240
LEU A 248
VAL A 249
HIS A 312
LEU A 321
 None
 0.79A 3ik3A-3d7uA:
31.5		 3ik3A-3d7uA:
44.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ALA A 220
GLU A 236
MET A 240
LEU A 248
HIS A 312
LEU A 321
 None
 0.63A 3ik3B-3d7uA:
31.2		 3ik3B-3d7uA:
44.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 GLU A 236
MET A 240
LEU A 248
VAL A 249
HIS A 312
LEU A 321
 None
 0.84A 3ik3B-3d7uA:
31.2		 3ik3B-3d7uA:
44.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		10 / 12 ALA A 220
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
TYR A 268
GLY A 272
LEU A 321
SER A 331
 None
 0.60A 3k54A-3d7uA:
27.8		 3k54A-3d7uA:
40.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		10 / 12 ALA A 220
LYS A 222
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
GLY A 272
LEU A 321
SER A 331
 None
 0.68A 3k54A-3d7uA:
27.8		 3k54A-3d7uA:
40.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ALA A 220
GLU A 236
MET A 240
THR A 266
GLY A 272
LEU A 321
 None
 0.47A 3k5vA-3d7uA:
31.7		 3k5vA-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 VAL A 209
ALA A 220
GLU A 236
MET A 240
THR A 266
LEU A 321
 None
 0.75A 3k5vA-3d7uA:
31.7		 3k5vA-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		4 / 6 LYS A 222
VAL A 239
VAL A 249
ILE A 264
 None
 0.59A 3k5vA-3d7uA:
31.7		 3k5vA-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ALA A 220
GLU A 236
MET A 240
THR A 266
GLY A 272
LEU A 321
 None
 0.45A 3k5vB-3d7uA:
26.8		 3k5vB-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		4 / 6 LYS A 222
VAL A 239
VAL A 249
ILE A 264
 None
 0.61A 3k5vB-3d7uA:
26.8		 3k5vB-3d7uA:
44.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 8 ALA A 220
LYS A 222
GLU A 236
THR A 266
MET A 269
 None
 0.53A 3lfaA-3d7uA:
17.6		 3lfaA-3d7uA:
23.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 GLY A 202
GLY A 204
VAL A 209
ALA A 220
TYR A 268
SER A 273
LEU A 321
 None
 0.70A 3lxnA-3d7uA:
31.4		 3lxnA-3d7uA:
35.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 11 ALA A 220
LYS A 222
MET A 269
GLY A 272
LEU A 321
ASP A 332
 None
 0.81A 3miyA-3d7uA:
27.4		 3miyA-3d7uA:
43.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 11 ALA A 220
LYS A 222
VAL A 249
MET A 269
GLY A 272
LEU A 321
 None
 0.70A 3miyA-3d7uA:
27.4		 3miyA-3d7uA:
43.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 11 ALA A 220
VAL A 249
MET A 269
GLY A 272
LEU A 321
SER A 331
 None
 0.77A 3miyA-3d7uA:
27.4		 3miyA-3d7uA:
43.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 9 ALA A 220
LYS A 222
MET A 269
GLY A 272
LEU A 321
 None
 0.68A 3miyB-3d7uA:
33.5		 3miyB-3d7uA:
43.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 VAL A 209
ALA A 220
GLU A 236
MET A 240
THR A 266
LEU A 321
 None
 0.75A 3ms9A-3d7uA:
26.9		 3ms9A-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		4 / 6 LYS A 222
VAL A 239
VAL A 249
ILE A 264
 None
 0.65A 3ms9A-3d7uA:
26.9		 3ms9A-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		4 / 6 VAL A 239
VAL A 249
ILE A 264
MET A 269
 None
 0.63A 3ms9A-3d7uA:
26.9		 3ms9A-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		4 / 6 VAL A 249
ILE A 264
MET A 269
ARG A 313
 None
 1.10A 3ms9A-3d7uA:
26.9		 3ms9A-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 VAL A 209
ALA A 220
GLU A 236
MET A 240
THR A 266
GLY A 272
LEU A 321
 None
 0.75A 3ms9B-3d7uA:
27.1		 3ms9B-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 6 LYS A 222
VAL A 239
VAL A 249
ILE A 264
ARG A 313
 None
 1.12A 3mssA-3d7uA:
27.0		 3mssA-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 6 VAL A 239
VAL A 249
ILE A 264
MET A 269
ARG A 313
 None
 1.09A 3mssA-3d7uA:
27.0		 3mssA-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ALA A 220
GLU A 236
MET A 240
THR A 266
GLY A 272
LEU A 321
 None
 0.51A 3mssB-3d7uA:
27.2		 3mssB-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 7 LYS A 222
VAL A 239
VAL A 249
ILE A 264
ARG A 313
 None
 0.97A 3mssB-3d7uA:
27.2		 3mssB-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 7 VAL A 239
VAL A 249
ILE A 264
MET A 269
ARG A 313
 None
 0.90A 3mssB-3d7uA:
27.2		 3mssB-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		4 / 6 LYS A 222
VAL A 239
VAL A 249
ILE A 264
 None
 0.64A 3mssC-3d7uA:
26.9		 3mssC-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ALA A 220
GLU A 236
MET A 240
THR A 266
GLY A 272
LEU A 321
 None
 0.53A 3mssD-3d7uA:
27.2		 3mssD-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 6 VAL A 209
LYS A 222
VAL A 239
VAL A 249
ILE A 264
 None
 0.58A 3mssD-3d7uA:
27.2		 3mssD-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		4 / 6 VAL A 209
VAL A 239
ILE A 264
MET A 269
 None
 0.81A 3mssD-3d7uA:
27.2		 3mssD-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		9 / 12 VAL A 209
ALA A 220
LYS A 222
MET A 240
VAL A 249
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.59A 3octA-3d7uA:
33.3		 3octA-3d7uA:
43.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 ALA A 220
GLU A 236
MET A 240
VAL A 249
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.62A 3oezA-3d7uA:
26.7		 3oezA-3d7uA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 VAL A 209
ALA A 220
GLU A 236
MET A 240
VAL A 249
THR A 266
TYR A 268
 None
 0.62A 3oezA-3d7uA:
26.7		 3oezA-3d7uA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		9 / 12 VAL A 209
ALA A 220
GLU A 236
VAL A 239
MET A 240
ILE A 264
THR A 266
TYR A 268
LEU A 321
 None
 0.58A 3oezB-3d7uA:
26.8		 3oezB-3d7uA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		9 / 12 VAL A 209
ALA A 220
LYS A 222
VAL A 239
MET A 240
ILE A 264
THR A 266
TYR A 268
LEU A 321
 None
 0.60A 3oezB-3d7uA:
26.8		 3oezB-3d7uA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ILE A 201
VAL A 209
ALA A 220
LYS A 222
THR A 266
GLY A 334
 None
 0.93A 3og7A-3d7uA:
23.1		 3og7A-3d7uA:
30.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 GLY A 202
VAL A 209
ALA A 220
LYS A 222
THR A 266
LEU A 321
 None
 0.88A 3ohtA-3d7uA:
17.2		 3ohtA-3d7uA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 GLY A 202
VAL A 209
ALA A 220
LYS A 222
THR A 266
GLY A 272
 None
 0.91A 3ohtB-3d7uA:
5.5		 3ohtB-3d7uA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 GLY A 202
VAL A 209
ALA A 220
LYS A 222
THR A 266
LEU A 321
 None
 0.91A 3ohtB-3d7uA:
5.5		 3ohtB-3d7uA:
23.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 ALA A 220
GLU A 236
MET A 240
LEU A 248
VAL A 249
THR A 266
GLY A 272
HIS A 312
 None
 0.54A 3oxzA-3d7uA:
26.9		 3oxzA-3d7uA:
44.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 GLU A 236
MET A 240
LEU A 248
VAL A 249
THR A 266
HIS A 312
ASP A 332
 None
 1.15A 3oxzA-3d7uA:
26.9		 3oxzA-3d7uA:
44.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 9 VAL A 239
ILE A 264
MET A 269
LEU A 321
VAL A 330
 None
 0.51A 3oxzA-3d7uA:
26.9		 3oxzA-3d7uA:
44.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ALA A 220
GLU A 236
MET A 240
THR A 266
GLY A 272
LEU A 321
 None
 0.56A 3pyyA-3d7uA:
27.1		 3pyyA-3d7uA:
42.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 6 LYS A 222
VAL A 239
VAL A 249
ILE A 264
ARG A 313
 None
 1.39A 3pyyA-3d7uA:
27.1		 3pyyA-3d7uA:
42.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 VAL A 209
ALA A 220
GLU A 236
MET A 240
VAL A 249
THR A 266
LEU A 321
 None
 0.63A 3pyyB-3d7uA:
27.1		 3pyyB-3d7uA:
42.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		10 / 12 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
VAL A 249
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.68A 3qlgA-3d7uA:
32.4		 3qlgA-3d7uA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 VAL A 209
ALA A 220
GLU A 236
MET A 240
VAL A 249
THR A 266
LEU A 321
ASP A 332
 None
 0.65A 3qlgB-3d7uA:
28.1		 3qlgB-3d7uA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		9 / 12 VAL A 209
ALA A 220
GLU A 236
MET A 240
VAL A 249
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.56A 3qlgB-3d7uA:
28.1		 3qlgB-3d7uA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		4 / 4 LYS A 222
ILE A 264
MET A 269
LYS A 271
 None
 1.00A 3qlgB-3d7uA:
28.1		 3qlgB-3d7uA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		9 / 12 VAL A 209
ALA A 220
MET A 240
VAL A 249
ILE A 264
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.53A 3sxrA-3d7uA:
32.8		 3sxrA-3d7uA:
42.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 VAL A 209
ALA A 220
MET A 240
VAL A 249
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.50A 3sxrB-3d7uA:
32.3		 3sxrB-3d7uA:
42.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 VAL A 209
ALA A 220
MET A 240
VAL A 249
THR A 266
TYR A 268
GLY A 272
SER A 331
 None
 0.67A 3sxrB-3d7uA:
32.3		 3sxrB-3d7uA:
42.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		9 / 12 ALA A 220
LYS A 222
GLU A 236
VAL A 249
ILE A 264
THR A 266
MET A 269
GLY A 272
LEU A 321
 None
 0.69A 3ue4A-3d7uA:
27.1		 3ue4A-3d7uA:
44.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		9 / 12 VAL A 209
ALA A 220
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
GLY A 272
LEU A 321
 None
 0.61A 3ue4B-3d7uA:
27.9		 3ue4B-3d7uA:
44.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 ILE A 201
GLY A 204
GLY A 207
VAL A 209
ALA A 220
LYS A 222
VAL A 249
LEU A 321
 None
 1.23A 3v5wA-3d7uA:
8.3		 3v5wA-3d7uA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 ILE A 201
GLY A 204
GLY A 207
VAL A 209
ALA A 220
VAL A 249
LEU A 321
SER A 331
 None
 1.25A 3v5wA-3d7uA:
8.3		 3v5wA-3d7uA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 ILE A 201
GLY A 204
VAL A 209
ALA A 220
LYS A 222
VAL A 249
ASP A 332
 None
 1.04A 3v5wA-3d7uA:
8.3		 3v5wA-3d7uA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 ILE A 201
GLY A 204
VAL A 209
ALA A 220
VAL A 249
LEU A 321
SER A 331
 None
 1.33A 3v5wA-3d7uA:
8.3		 3v5wA-3d7uA:
17.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 VAL A 209
ALA A 220
LYS A 222
GLU A 236
GLY A 272
LEU A 305
HIS A 312
 None
 0.62A 3wzeA-3d7uA:
26.1		 3wzeA-3d7uA:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 12 ALA A 220
MET A 269
GLY A 272
LEU A 321
ASP A 332
 None
 0.46A 3zbfA-3d7uA:
27.2		 3zbfA-3d7uA:
34.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 ALA A 220
LYS A 222
GLU A 236
THR A 266
LEU A 305
HIS A 312
ARG A 313
LEU A 321
 None
 0.62A 3zosA-3d7uA:
24.1		 3zosA-3d7uA:
32.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 ALA A 220
LYS A 222
GLU A 236
THR A 266
LEU A 305
HIS A 312
ARG A 313
LEU A 321
 None
 0.64A 3zosB-3d7uA:
24.1		 3zosB-3d7uA:
32.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 VAL A 209
ALA A 220
LYS A 222
GLU A 236
VAL A 249
GLY A 272
LEU A 321
 None
 0.54A 4ag8A-3d7uA:
25.5		 4ag8A-3d7uA:
35.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 VAL A 209
ALA A 220
LYS A 222
GLU A 236
GLY A 272
LEU A 321
 None
 0.54A 4agcA-3d7uA:
25.2		 4agcA-3d7uA:
32.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 9 VAL A 209
ALA A 220
MET A 269
GLY A 272
LEU A 321
ASP A 332
 None
 0.68A 4anqA-3d7uA:
27.3		 4anqA-3d7uA:
32.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 9 VAL A 209
ALA A 220
MET A 269
GLY A 272
LEU A 321
ASP A 332
 None
 0.71A 4ansA-3d7uA:
27.3		 4ansA-3d7uA:
32.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 VAL A 209
ALA A 220
GLU A 236
MET A 240
THR A 266
TYR A 268
 None
 0.69A 4bkjA-3d7uA:
24.3		 4bkjA-3d7uA:
32.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		4 / 4 LYS A 222
LEU A 243
MET A 269
ARG A 313
 None
 1.15A 4bkjA-3d7uA:
24.3		 4bkjA-3d7uA:
32.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 5 LYS A 222
LEU A 243
TYR A 268
MET A 269
ARG A 313
 None
 1.29A 4bkjB-3d7uA:
24.3		 4bkjB-3d7uA:
32.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 ALA A 220
LYS A 222
GLU A 236
ILE A 264
THR A 266
HIS A 312
LEU A 321
 None
 0.51A 4c8bA-3d7uA:
20.8		 4c8bA-3d7uA:
27.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 11 GLY A 202
VAL A 209
ALA A 220
TYR A 268
GLY A 272
SER A 273
LEU A 321
 None
 0.38A 4ckiA-3d7uA:
28.7		 4ckiA-3d7uA:
35.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 10 GLY A 202
GLY A 204
VAL A 209
ALA A 220
TYR A 268
SER A 273
LEU A 321
 None
 0.55A 4ckjA-3d7uA:
28.3		 4ckjA-3d7uA:
35.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 VAL A 209
ALA A 220
GLU A 236
MET A 240
VAL A 249
THR A 266
TYR A 268
LEU A 321
 None
 0.75A 4csvA-3d7uA:
27.3		 4csvA-3d7uA:
46.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 ALA A 220
LYS A 222
THR A 266
MET A 269
GLY A 272
LEU A 321
ASP A 332
 None
 0.92A 4hjoA-3d7uA:
31.4		 4hjoA-3d7uA:
34.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 VAL A 209
ALA A 220
THR A 266
MET A 269
GLY A 272
LEU A 321
ASP A 332
 None
 0.66A 4hjoA-3d7uA:
31.4		 4hjoA-3d7uA:
34.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 10 ILE A 201
ALA A 220
VAL A 249
GLY A 272
LEU A 321
SER A 331
 None
 0.74A 4ks8A-3d7uA:
26.9		 4ks8A-3d7uA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 10 ILE A 201
ALA A 220
VAL A 249
LEU A 321
SER A 331
ASP A 332
 None
 1.02A 4ks8A-3d7uA:
26.9		 4ks8A-3d7uA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		4 / 7 VAL A 209
ALA A 220
MET A 269
LEU A 321
 None
 0.64A 4l9iA-3d7uA:
9.0		 4l9iA-3d7uA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 8 GLY A 204
VAL A 209
ALA A 220
LYS A 222
MET A 269
LEU A 321
 None
 0.72A 4l9iB-3d7uA:
6.7		 4l9iB-3d7uA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 8 GLY A 207
VAL A 209
ALA A 220
MET A 269
LEU A 321
 None
 1.33A 4l9iB-3d7uA:
6.7		 4l9iB-3d7uA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 12 LEU A 305
VAL A 320
LEU A 274
LEU A 315
LEU A 248
 None
 1.25A 4m11A-3d7uA:
undetectable		 4m11A-3d7uA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		3 / 3 ARG A 384
ASP A 409
ARG A 389
 None
 0.84A 4mx0A-3d7uA:
undetectable		 4mx0A-3d7uA:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		11 / 12 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
TYR A 268
GLY A 272
ASP A 332
 None
 0.84A 4mxoA-3d7uA:
28.2		 4mxoA-3d7uA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 VAL A 209
ALA A 220
GLU A 236
VAL A 249
ILE A 264
THR A 266
LEU A 321
ASP A 332
 None
 0.82A 4mxoB-3d7uA:
28.3		 4mxoB-3d7uA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		9 / 12 VAL A 209
ALA A 220
LYS A 222
ILE A 264
THR A 266
TYR A 268
GLY A 272
LEU A 321
ASP A 332
 None
 0.83A 4mxoB-3d7uA:
28.3		 4mxoB-3d7uA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		9 / 12 VAL A 209
ALA A 220
VAL A 249
ILE A 264
THR A 266
TYR A 268
GLY A 272
LEU A 321
ASP A 332
 None
 0.69A 4mxoB-3d7uA:
28.3		 4mxoB-3d7uA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		9 / 12 ALA A 220
LYS A 222
GLU A 236
MET A 240
VAL A 249
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.86A 4mxxA-3d7uA:
27.9		 4mxxA-3d7uA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		9 / 12 ALA A 220
LYS A 222
GLU A 236
VAL A 249
ILE A 264
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.77A 4mxxA-3d7uA:
27.9		 4mxxA-3d7uA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 VAL A 209
ALA A 220
LYS A 222
VAL A 249
THR A 266
MET A 269
GLY A 272
LEU A 321
 None
 0.69A 4mxxB-3d7uA:
25.8		 4mxxB-3d7uA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 VAL A 209
ALA A 220
VAL A 249
THR A 266
TYR A 268
MET A 269
GLY A 272
LEU A 321
 None
 0.53A 4mxxB-3d7uA:
25.8		 4mxxB-3d7uA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		9 / 12 VAL A 209
ALA A 220
GLU A 236
VAL A 249
ILE A 264
TYR A 268
GLY A 272
LEU A 321
ASP A 332
 None
 0.69A 4mxyA-3d7uA:
27.3		 4mxyA-3d7uA:
40.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 VAL A 209
ALA A 220
LYS A 222
ILE A 264
TYR A 268
GLY A 272
LEU A 321
ASP A 332
 None
 0.59A 4mxyA-3d7uA:
27.3		 4mxyA-3d7uA:
40.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 VAL A 209
ALA A 220
VAL A 249
TYR A 268
GLY A 272
LEU A 321
ASP A 332
 None
 0.59A 4mxyB-3d7uA:
27.2		 4mxyB-3d7uA:
40.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		9 / 12 VAL A 209
ALA A 220
GLU A 236
VAL A 249
ILE A 264
TYR A 268
GLY A 272
LEU A 321
ASP A 332
 None
 0.69A 4mxzA-3d7uA:
27.3		 4mxzA-3d7uA:
40.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 VAL A 209
ALA A 220
LYS A 222
ILE A 264
TYR A 268
GLY A 272
LEU A 321
ASP A 332
 None
 0.59A 4mxzA-3d7uA:
27.3		 4mxzA-3d7uA:
40.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 VAL A 209
ALA A 220
VAL A 249
TYR A 268
GLY A 272
LEU A 321
ASP A 332
 None
 0.59A 4mxzB-3d7uA:
27.2		 4mxzB-3d7uA:
40.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 11 GLY A 202
VAL A 209
ALA A 220
LYS A 222
ASN A 319
LEU A 321
ASP A 332
 None
 0.94A 4o0sA-3d7uA:
27.4		 4o0sA-3d7uA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 8 ILE A 201
VAL A 209
ALA A 220
ASN A 319
LEU A 321
ASP A 332
 None
 0.65A 4ogrA-3d7uA:
19.0		 4ogrA-3d7uA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 9 ILE A 201
VAL A 209
ALA A 220
ASN A 319
LEU A 321
ASP A 332
 None
 0.61A 4ogrI-3d7uA:
26.4		 4ogrI-3d7uA:
26.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 VAL A 209
LYS A 222
VAL A 249
THR A 266
TYR A 268
GLY A 272
LEU A 321
ASP A 332
 None
 0.87A 4otwA-3d7uA:
25.6		 4otwA-3d7uA:
32.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ALA A 220
GLU A 236
ILE A 264
TYR A 268
LEU A 321
ASP A 332
 None
 0.53A 4qmnA-3d7uA:
28.0		 4qmnA-3d7uA:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ILE A 201
ALA A 220
GLU A 236
ILE A 264
TYR A 268
ASP A 332
 None
 0.80A 4qmnA-3d7uA:
28.0		 4qmnA-3d7uA:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 11 ALA A 220
GLU A 236
ILE A 264
TYR A 268
LEU A 321
ASP A 332
 None
 0.51A 4qmsA-3d7uA:
28.2		 4qmsA-3d7uA:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 11 ALA A 220
LYS A 222
ILE A 264
TYR A 268
LEU A 321
ASP A 332
 None
 0.81A 4qmsA-3d7uA:
28.2		 4qmsA-3d7uA:
28.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 12 ALA A 220
GLU A 236
MET A 240
LEU A 305
ARG A 313
 None
 0.72A 4qrcA-3d7uA:
25.5		 4qrcA-3d7uA:
40.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
THR A 266
LEU A 321
 None
 0.48A 4r7iA-3d7uA:
24.7		 4r7iA-3d7uA:
35.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 10 ILE A 201
ALA A 220
LYS A 222
THR A 266
LEU A 321
 None
 0.70A 4rz7A-3d7uA:
8.0		 4rz7A-3d7uA:
15.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ALA A 220
LYS A 222
ILE A 264
THR A 266
SER A 273
PHE A 333
 None
 0.81A 4rzvA-3d7uA:
28.3		 4rzvA-3d7uA:
31.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 VAL A 209
ALA A 220
LYS A 222
THR A 266
SER A 273
PHE A 333
 None
 0.88A 4rzvB-3d7uA:
27.8		 4rzvB-3d7uA:
31.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 VAL A 209
ALA A 220
LYS A 222
MET A 269
GLY A 272
ASN A 319
LEU A 321
ASP A 332
 None
 0.67A 4twpA-3d7uA:
28.5		 4twpA-3d7uA:
43.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 12 ALA A 220
GLU A 236
MET A 240
HIS A 312
LEU A 321
 None
 0.48A 4tyjA-3d7uA:
26.9		 4tyjA-3d7uA:
40.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 10 VAL A 209
GLU A 236
LEU A 243
VAL A 249
TYR A 268
ARG A 313
 None
 0.87A 4u0iA-3d7uA:
26.3		 4u0iA-3d7uA:
34.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ALA A 220
LYS A 222
THR A 266
GLY A 272
HIS A 312
LEU A 321
 None
 0.44A 4u0iA-3d7uA:
26.3		 4u0iA-3d7uA:
34.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		9 / 11 GLY A 204
VAL A 209
ALA A 220
TYR A 268
MET A 269
GLY A 272
ASN A 319
LEU A 321
ASP A 332
 None
 0.41A 4u5jA-3d7uA:
28.4		 4u5jA-3d7uA:
42.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		9 / 11 GLY A 207
VAL A 209
ALA A 220
TYR A 268
MET A 269
GLY A 272
ASN A 319
LEU A 321
ASP A 332
 None
 1.02A 4u5jA-3d7uA:
28.4		 4u5jA-3d7uA:
42.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 9 ALA A 220
TYR A 268
MET A 269
GLY A 272
LEU A 321
ASP A 332
 None
 0.63A 4u5jB-3d7uA:
27.8		 4u5jB-3d7uA:
42.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 9 VAL A 209
ALA A 220
TYR A 268
MET A 269
GLY A 272
LEU A 321
 None
 0.42A 4u5jB-3d7uA:
27.8		 4u5jB-3d7uA:
42.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 12 ALA A 220
GLU A 236
MET A 240
LEU A 305
HIS A 312
 None
 0.72A 4v01A-3d7uA:
25.9		 4v01A-3d7uA:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 12 ALA A 220
GLU A 236
MET A 240
LEU A 305
HIS A 312
 None
 0.63A 4v01B-3d7uA:
31.1		 4v01B-3d7uA:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		4 / 8 LYS A 222
MET A 240
TYR A 268
LEU A 321
 None
 0.68A 4v04A-3d7uA:
25.0		 4v04A-3d7uA:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		4 / 8 MET A 240
TYR A 268
ARG A 313
LEU A 321
 None
 0.75A 4v04A-3d7uA:
25.0		 4v04A-3d7uA:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 10 VAL A 209
LYS A 222
MET A 240
TYR A 268
ARG A 313
LEU A 321
 None
 1.04A 4v04B-3d7uA:
25.5		 4v04B-3d7uA:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 11 ALA A 220
THR A 266
MET A 269
GLY A 272
ASN A 319
LEU A 321
 None
 0.33A 4wa9A-3d7uA:
30.0		 4wa9A-3d7uA:
44.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 VAL A 209
ALA A 220
LYS A 222
THR A 266
MET A 269
GLY A 272
LEU A 321
 None
 0.72A 4wa9B-3d7uA:
27.5		 4wa9B-3d7uA:
44.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 VAL A 209
ALA A 220
THR A 266
MET A 269
GLY A 272
ASN A 319
LEU A 321
 None
 0.60A 4wa9B-3d7uA:
27.5		 4wa9B-3d7uA:
44.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 ALA A 220
LYS A 222
GLU A 236
MET A 240
THR A 266
GLY A 272
ASP A 276
LEU A 321
 None
 0.69A 4wkqA-3d7uA:
32.6		 4wkqA-3d7uA:
34.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 12 LEU A 274
GLY A 288
LEU A 292
VAL A 415
VAL A 298
 None
 0.99A 4wnwB-3d7uA:
undetectable		 4wnwB-3d7uA:
21.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		9 / 12 VAL A 209
ALA A 220
LYS A 222
MET A 240
VAL A 249
ILE A 264
THR A 266
GLY A 272
LEU A 321
 None
 0.54A 4xeyA-3d7uA:
27.4		 4xeyA-3d7uA:
33.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 ALA A 220
LYS A 222
MET A 240
VAL A 249
ILE A 264
THR A 266
GLY A 272
LEU A 321
 None
 0.55A 4xeyB-3d7uA:
33.3		 4xeyB-3d7uA:
33.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 VAL A 209
ALA A 220
MET A 240
VAL A 249
ILE A 264
THR A 266
GLY A 272
LEU A 321
 None
 0.38A 4xeyB-3d7uA:
33.3		 4xeyB-3d7uA:
33.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		9 / 12 ALA A 220
GLU A 236
MET A 240
VAL A 249
THR A 266
TYR A 268
MET A 269
GLY A 272
LEU A 321
 None
 0.51A 4xliA-3d7uA:
28.5		 4xliA-3d7uA:
46.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		9 / 12 ALA A 220
LYS A 222
GLU A 236
VAL A 249
THR A 266
TYR A 268
MET A 269
GLY A 272
LEU A 321
 None
 0.83A 4xliA-3d7uA:
28.5		 4xliA-3d7uA:
46.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		10 / 12 ALA A 220
LYS A 222
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.61A 4xliB-3d7uA:
27.5		 4xliB-3d7uA:
46.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 VAL A 209
ALA A 220
LYS A 222
THR A 266
ASP A 332
PHE A 333
 None
 0.92A 4xv2A-3d7uA:
23.1		 4xv2A-3d7uA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 12 ALA A 220
LYS A 222
THR A 266
ASP A 332
PHE A 333
 None
 0.88A 4xv2B-3d7uA:
28.4		 4xv2B-3d7uA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 9 VAL A 209
ALA A 220
MET A 269
GLY A 272
LEU A 321
ASP A 332
 None
 0.65A 5aaaA-3d7uA:
26.3		 5aaaA-3d7uA:
34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 10 VAL A 209
ALA A 220
LYS A 222
MET A 269
GLY A 272
LEU A 321
ASP A 332
 None
 0.84A 5aabA-3d7uA:
26.3		 5aabA-3d7uA:
34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		9 / 12 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.77A 5bvwA-3d7uA:
24.2		 5bvwA-3d7uA:
32.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 12 VAL A 209
ALA A 220
LYS A 222
THR A 266
PHE A 333
 None
 0.86A 5cswA-3d7uA:
23.0		 5cswA-3d7uA:
31.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 12 VAL A 209
ALA A 220
THR A 266
GLY A 272
LEU A 321
 None
 0.50A 5h2uA-3d7uA:
24.7		 5h2uA-3d7uA:
43.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 VAL A 209
ALA A 220
ILE A 264
THR A 266
GLY A 272
LEU A 321
ASP A 332
 None
 0.76A 5h2uB-3d7uA:
24.9		 5h2uB-3d7uA:
43.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 12 ALA A 220
ILE A 264
THR A 266
GLY A 272
LEU A 321
 None
 0.52A 5h2uC-3d7uA:
24.8		 5h2uC-3d7uA:
43.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 VAL A 209
ALA A 220
ILE A 264
THR A 266
GLY A 272
LEU A 321
 None
 0.55A 5h2uD-3d7uA:
24.6		 5h2uD-3d7uA:
43.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 VAL A 209
ALA A 220
ILE A 264
THR A 266
ASP A 276
PHE A 333
GLY A 334
 None
 0.99A 5hesA-3d7uA:
27.4		 5hesA-3d7uA:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 VAL A 209
ALA A 220
ILE A 264
THR A 266
TYR A 268
ASP A 276
PHE A 333
 None
 0.85A 5hesA-3d7uA:
27.4		 5hesA-3d7uA:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 VAL A 209
ALA A 220
LYS A 222
ILE A 264
THR A 266
ASP A 276
GLY A 334
 None
 0.88A 5hesB-3d7uA:
21.8		 5hesB-3d7uA:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 VAL A 209
ALA A 220
LYS A 222
ILE A 264
THR A 266
TYR A 268
ASP A 276
PHE A 333
 None
 0.83A 5hesB-3d7uA:
21.8		 5hesB-3d7uA:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ALA A 220
LYS A 222
GLU A 236
THR A 266
LEU A 305
HIS A 312
 None
 0.67A 5hi2A-3d7uA:
19.9		 5hi2A-3d7uA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 12 VAL A 209
ALA A 220
LYS A 222
ILE A 264
THR A 266
 None
 0.50A 5hieA-3d7uA:
10.5		 5hieA-3d7uA:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 12 VAL A 209
ALA A 220
LYS A 222
ILE A 264
THR A 266
 None
 0.50A 5hieB-3d7uA:
10.5		 5hieB-3d7uA:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 12 VAL A 209
ALA A 220
LYS A 222
THR A 266
ASP A 332
 None
 0.60A 5hieC-3d7uA:
27.8		 5hieC-3d7uA:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 12 VAL A 209
ALA A 220
LYS A 222
ILE A 264
THR A 266
 None
 0.50A 5hieD-3d7uA:
27.7		 5hieD-3d7uA:
29.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 ILE A 201
ALA A 220
GLU A 236
ILE A 264
THR A 266
GLY A 272
LEU A 321
SER A 331
 None
 0.77A 5i9xA-3d7uA:
32.8		 5i9xA-3d7uA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 ILE A 201
ALA A 220
ILE A 264
THR A 266
TYR A 268
GLY A 272
LEU A 321
SER A 331
 None
 0.65A 5i9xA-3d7uA:
32.8		 5i9xA-3d7uA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 ILE A 201
ALA A 220
LYS A 222
GLU A 236
ILE A 264
THR A 266
GLY A 272
LEU A 321
 None
 0.97A 5i9xA-3d7uA:
32.8		 5i9xA-3d7uA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 ILE A 201
ALA A 220
LYS A 222
ILE A 264
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.77A 5i9xA-3d7uA:
32.8		 5i9xA-3d7uA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		9 / 12 ILE A 201
ALA A 220
LYS A 222
GLU A 236
MET A 240
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.86A 5i9yA-3d7uA:
26.5		 5i9yA-3d7uA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 ILE A 201
ALA A 220
LYS A 222
THR A 266
TYR A 268
GLY A 272
LEU A 321
SER A 331
 None
 0.64A 5i9yA-3d7uA:
26.5		 5i9yA-3d7uA:
38.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 7 GLY A 202
GLY A 204
VAL A 209
LYS A 222
ASP A 332
 None
 0.76A 5j5xA-3d7uA:
24.4		 5j5xA-3d7uA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ILE A 201
GLY A 202
VAL A 209
ALA A 220
VAL A 249
LEU A 321
 None
 0.72A 5l2iA-3d7uA:
7.2		 5l2iA-3d7uA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 ILE A 201
GLY A 202
VAL A 209
ALA A 220
LYS A 222
GLU A 236
TYR A 268
GLY A 272
 None
 0.82A 5mafA-3d7uA:
26.9		 5mafA-3d7uA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 10 VAL A 209
GLU A 236
ILE A 264
MET A 269
GLY A 272
 None
 0.62A 5mo4A-3d7uA:
26.8		 5mo4A-3d7uA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ALA A 220
MET A 240
LEU A 248
VAL A 249
HIS A 312
LEU A 321
 None
 0.69A 5mo4A-3d7uA:
26.8		 5mo4A-3d7uA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ALA A 220
VAL A 239
MET A 240
VAL A 249
HIS A 312
LEU A 321
 None
 0.65A 5mo4A-3d7uA:
26.8		 5mo4A-3d7uA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		4 / 8 ALA A 220
GLU A 236
LEU A 321
ASP A 332
 None
 0.51A 5owrA-3d7uA:
22.3		 5owrA-3d7uA:
26.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ALA A 220
ILE A 264
THR A 266
GLY A 272
LEU A 321
PHE A 333
 None
 0.96A 5p9iA-3d7uA:
31.9		 5p9iA-3d7uA:
43.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ALA A 220
THR A 266
GLY A 272
LEU A 321
SER A 331
PHE A 333
 None
 0.92A 5p9iA-3d7uA:
31.9		 5p9iA-3d7uA:
43.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 VAL A 209
ALA A 220
ILE A 264
THR A 266
GLY A 272
LEU A 321
 None
 0.58A 5p9iA-3d7uA:
31.9		 5p9iA-3d7uA:
43.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 VAL A 209
ALA A 220
THR A 266
GLY A 272
LEU A 321
SER A 331
 None
 0.68A 5p9iA-3d7uA:
31.9		 5p9iA-3d7uA:
43.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 LEU A 211
ALA A 220
GLU A 236
MET A 240
VAL A 249
GLY A 272
LEU A 321
 None
 0.55A 5te0A-3d7uA:
25.9		 5te0A-3d7uA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		3 / 3 HIS A 312
SER A 331
ARG A 318
 None
 0.92A 5u63A-3d7uA:
undetectable		 5u63A-3d7uA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 GLY A 202
ALA A 220
GLU A 236
TYR A 268
GLY A 272
ASP A 332
 None
 0.85A 5vc3A-3d7uA:
20.2		 5vc3A-3d7uA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 ALA A 220
LYS A 222
GLU A 236
VAL A 249
THR A 266
GLY A 272
 None
 1.13A 5vcvA-3d7uA:
25.2		 5vcvA-3d7uA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 12 ARG A 318
ILE A 201
ALA A 220
THR A 266
GLY A 334
 None
 1.09A 5veuA-3d7uA:
undetectable		 5veuA-3d7uA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 VAL A 209
ALA A 220
GLU A 236
THR A 266
GLY A 272
LEU A 321
ASP A 332
 None
 0.63A 5y80A-3d7uA:
24.4		 5y80A-3d7uA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 GLY A 202
VAL A 209
ALA A 220
ASP A 276
LEU A 321
ASP A 332
 None
 0.75A 5yu9B-3d7uA:
24.5		 5yu9B-3d7uA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 12 VAL A 209
ALA A 220
GLY A 272
ASP A 276
ASP A 332
 None
 0.71A 5yu9C-3d7uA:
24.2		 5yu9C-3d7uA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 VAL A 209
ALA A 220
GLY A 272
ASP A 276
LEU A 321
ASP A 332
 None
 0.79A 5yu9D-3d7uA:
24.2		 5yu9D-3d7uA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 VAL A 209
ALA A 220
GLU A 236
MET A 240
TYR A 268
GLY A 272
 None
 0.62A 5zv2A-3d7uA:
25.8		 5zv2A-3d7uA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		6 / 12 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
GLY A 272
 None
 0.62A 5zv2B-3d7uA:
31.0		 5zv2B-3d7uA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		3 / 3 TYR A 268
LEU A 321
ASP A 332
 None
 0.59A 5zv2B-3d7uA:
31.0		 5zv2B-3d7uA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		10 / 12 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
THR A 266
TYR A 268
MET A 269
GLY A 272
LEU A 321
 None
 0.73A 6bsdA-3d7uA:
29.7		 6bsdA-3d7uA:
14.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 ILE A 201
VAL A 209
ALA A 220
LYS A 222
GLU A 236
ILE A 264
THR A 266
MET A 269
 None
 0.89A 6fnmA-3d7uA:
28.1		 6fnmA-3d7uA:
38.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 ILE A 201
VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
THR A 266
MET A 269
 None
 0.98A 6fnmA-3d7uA:
28.1		 6fnmA-3d7uA:
38.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 ILE A 201
VAL A 209
ALA A 220
LYS A 222
ILE A 264
THR A 266
MET A 269
GLY A 272
 None
 0.79A 6fnmA-3d7uA:
28.1		 6fnmA-3d7uA:
38.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 ILE A 201
VAL A 209
ALA A 220
LYS A 222
MET A 240
THR A 266
MET A 269
GLY A 272
 None
 1.07A 6fnmA-3d7uA:
28.1		 6fnmA-3d7uA:
38.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		9 / 12 VAL A 209
ALA A 220
LYS A 222
ILE A 264
THR A 266
MET A 269
GLY A 272
LEU A 321
SER A 331
 None
 0.74A 6fnmA-3d7uA:
28.1		 6fnmA-3d7uA:
38.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		9 / 12 VAL A 209
ALA A 220
LYS A 222
MET A 240
THR A 266
MET A 269
GLY A 272
LEU A 321
SER A 331
 None
 1.01A 6fnmA-3d7uA:
28.1		 6fnmA-3d7uA:
38.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 VAL A 209
ALA A 220
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
LEU A 321
 None
 0.70A 6hd4A-3d7uA:
26.8		 6hd4A-3d7uA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
 None
 0.59A 6hd4A-3d7uA:
26.8		 6hd4A-3d7uA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 VAL A 209
ALA A 220
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
LEU A 321
 None
 0.67A 6hd4B-3d7uA:
26.8		 6hd4B-3d7uA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
 None
 0.63A 6hd4B-3d7uA:
26.8		 6hd4B-3d7uA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 VAL A 209
ALA A 220
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
LEU A 321
 None
 0.69A 6hd6A-3d7uA:
31.7		 6hd6A-3d7uA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		8 / 12 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
 None
 0.60A 6hd6A-3d7uA:
31.7		 6hd6A-3d7uA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		7 / 12 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
VAL A 249
THR A 266
 None
 0.65A 6hd6B-3d7uA:
26.7		 6hd6B-3d7uA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens) 		5 / 7 VAL A 239
ILE A 264
MET A 269
GLY A 272
ARG A 313
 None
 1.01A 6hd6B-3d7uA:
26.7		 6hd6B-3d7uA:
15.53