SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d89'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UDU_A_CIAA1003_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	3d89	RIESKE DOMAIN-CONTAINING PROTEIN (Mus musculus)	5 / 11	ILE A 55 VAL A 42 ALA A 52 LEU A 89 ILE A 119	None	1.23A	1uduA-3d89A: undetectable	1uduA-3d89A: 21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UDU_A_CIAA1003_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	3d89	RIESKE DOMAIN-CONTAINING PROTEIN (Mus musculus)	5 / 11	VAL A 42 ALA A 52 PHE A 44 LEU A 89 ILE A 119	None	1.27A	1uduA-3d89A: undetectable	1uduA-3d89A: 21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YVM_A_TMGA501_1 (METHIONINE AMINOPEPTIDASE)	3d89	RIESKE DOMAIN-CONTAINING PROTEIN (Mus musculus)	4 / 7	CYH A 57 TYR A 145 CYH A 80 HIS A 83	FES A 201 (-2.3A) None FES A 201 (-2.3A) FES A 201 (-3.2A)	1.23A	1yvmA-3d89A: undetectable	1yvmA-3d89A: 18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Z9H_A_IMNA379_1 (MEMBRANE-ASSOCIATED PROSTAGLANDIN E SYNTHASE-2)	3d89	RIESKE DOMAIN-CONTAINING PROTEIN (Mus musculus)	5 / 12	TYR A 85 CYH A 80 PRO A 81 VAL A 42 ILE A 87	FES A 201 (-4.0A) FES A 201 (-2.3A) None None None	1.08A	1z9hA-3d89A: undetectable	1z9hA-3d89A: 17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Z9H_B_IMNB381_1 (MEMBRANE-ASSOCIATED PROSTAGLANDIN E SYNTHASE-2)	3d89	RIESKE DOMAIN-CONTAINING PROTEIN (Mus musculus)	5 / 12	TYR A 85 CYH A 80 PRO A 81 VAL A 42 ILE A 87	FES A 201 (-4.0A) FES A 201 (-2.3A) None None None	1.07A	1z9hB-3d89A: undetectable	1z9hB-3d89A: 17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Z9H_C_IMNC379_1 (MEMBRANE-ASSOCIATED PROSTAGLANDIN E SYNTHASE-2)	3d89	RIESKE DOMAIN-CONTAINING PROTEIN (Mus musculus)	5 / 12	TYR A 85 CYH A 80 PRO A 81 VAL A 42 ILE A 87	FES A 201 (-4.0A) FES A 201 (-2.3A) None None None	1.09A	1z9hC-3d89A: undetectable	1z9hC-3d89A: 17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MB5_A_SAMA301_1 (SAM-DEPENDENT METHYLTRANSFERASE)	3d89	RIESKE DOMAIN-CONTAINING PROTEIN (Mus musculus)	4 / 4	GLY A 127 GLU A 23 ASP A 25 ASP A 125	None	1.33A	3mb5A-3d89A: undetectable	3mb5A-3d89A: 20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MBG_C_ACTC800_0 (FAD-LINKED SULFHYDRYL OXIDASE ALR)	3d89	RIESKE DOMAIN-CONTAINING PROTEIN (Mus musculus)	3 / 3	ASP A 54 ARG A 118 ALA A 146	None	0.74A	3mbgC-3d89A: undetectable	3mbgC-3d89A: 19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4APJ_A_ACTA1635_0 (ANGIOTENSIN-CONVERTI NG ENZYME BRADYKININ-POTENTIAT ING PEPTIDE B)	3d89	RIESKE DOMAIN-CONTAINING PROTEIN (Mus musculus)	4 / 6	HIS A 120 ASP A 143 SER A 142 PRO A 137	None	1.36A	4apjA-3d89A: undetectable 4apjP-3d89A: undetectable	4apjA-3d89A: 12.79 4apjP-3d89A: 43.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZBR_A_ACTA608_0 (SERUM ALBUMIN)	3d89	RIESKE DOMAIN-CONTAINING PROTEIN (Mus musculus)	3 / 3	LYS A 14 ARG A 39 HIS A 120	None	1.26A	4zbrA-3d89A: undetectable	4zbrA-3d89A: 14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F8Y_A_X6XA202_1 (GALNAC/GAL-SPECIFIC LECTIN)	3d89	RIESKE DOMAIN-CONTAINING PROTEIN (Mus musculus)	4 / 8	HIS A 59 GLY A 62 GLY A 61 HIS A 83	FES A 201 (-3.1A) FES A 201 (-3.9A) FES A 201 ( 4.6A) FES A 201 (-3.2A)	0.76A	5f8yA-3d89A: undetectable	5f8yA-3d89A: 22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F8Y_B_X6XB201_1 (GALNAC/GAL-SPECIFIC LECTIN)	3d89	RIESKE DOMAIN-CONTAINING PROTEIN (Mus musculus)	4 / 8	HIS A 59 GLY A 62 GLY A 61 HIS A 83	FES A 201 (-3.1A) FES A 201 (-3.9A) FES A 201 ( 4.6A) FES A 201 (-3.2A)	0.72A	5f8yB-3d89A: undetectable	5f8yB-3d89A: 22.78

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1UDU_A_CIAA1003_1","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE","3d89","RIESKE DOMAIN-CONTAINING PROTEIN","Mus musculus",5,"ILE A  55;VAL A  42;ALA A  52;LEU A  89;ILE A 119","None","1.23A","1uduA-3d89A:undetectable","1uduA-3d89A:21.02"],["1UDU_A_CIAA1003_1","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE","3d89","RIESKE DOMAIN-CONTAINING PROTEIN","Mus musculus",5,"VAL A  42;ALA A  52;PHE A  44;LEU A  89;ILE A 119","None","1.27A","1uduA-3d89A:undetectable","1uduA-3d89A:21.02"],["1YVM_A_TMGA501_1","METHIONINE AMINOPEPTIDASE","3d89","RIESKE DOMAIN-CONTAINING PROTEIN","Mus musculus",4,"CYH A  57;TYR A 145;CYH A  80;HIS A  83","FES A 201 (-2.3A);None;FES A 201 (-2.3A);FES A 201 (-3.2A)","1.23A","1yvmA-3d89A:undetectable","1yvmA-3d89A:18.18"],["1Z9H_A_IMNA379_1","MEMBRANE-ASSOCIATED PROSTAGLANDIN E SYNTHASE-2","3d89","RIESKE DOMAIN-CONTAINING PROTEIN","Mus musculus",5,"TYR A  85;CYH A  80;PRO A  81;VAL A  42;ILE A  87","FES A 201 (-4.0A);FES A 201 (-2.3A);None;None;None","1.08A","1z9hA-3d89A:undetectable","1z9hA-3d89A:17.89"],["1Z9H_B_IMNB381_1","MEMBRANE-ASSOCIATED PROSTAGLANDIN E SYNTHASE-2","3d89","RIESKE DOMAIN-CONTAINING PROTEIN","Mus musculus",5,"TYR A  85;CYH A  80;PRO A  81;VAL A  42;ILE A  87","FES A 201 (-4.0A);FES A 201 (-2.3A);None;None;None","1.07A","1z9hB-3d89A:undetectable","1z9hB-3d89A:17.89"],["1Z9H_C_IMNC379_1","MEMBRANE-ASSOCIATED PROSTAGLANDIN E SYNTHASE-2","3d89","RIESKE DOMAIN-CONTAINING PROTEIN","Mus musculus",5,"TYR A  85;CYH A  80;PRO A  81;VAL A  42;ILE A  87","FES A 201 (-4.0A);FES A 201 (-2.3A);None;None;None","1.09A","1z9hC-3d89A:undetectable","1z9hC-3d89A:17.89"],["3MB5_A_SAMA301_1","SAM-DEPENDENT METHYLTRANSFERASE","3d89","RIESKE DOMAIN-CONTAINING PROTEIN","Mus musculus",4,"GLY A 127;GLU A  23;ASP A  25;ASP A 125","None","1.33A","3mb5A-3d89A:undetectable","3mb5A-3d89A:20.47"],["3MBG_C_ACTC800_0","FAD-LINKED SULFHYDRYL OXIDASE ALR","3d89","RIESKE DOMAIN-CONTAINING PROTEIN","Mus musculus",3,"ASP A  54;ARG A 118;ALA A 146","None","0.74A","3mbgC-3d89A:undetectable","3mbgC-3d89A:19.64"],["4APJ_A_ACTA1635_0","ANGIOTENSIN-CONVERTING ENZYME;BRADYKININ-POTENTIATING PEPTIDE B","3d89","RIESKE DOMAIN-CONTAINING PROTEIN","Mus musculus",4,"HIS A 120;ASP A 143;SER A 142;PRO A 137","None","1.36A","4apjA-3d89A:undetectable;4apjP-3d89A:undetectable","4apjA-3d89A:12.79;4apjP-3d89A:43.75"],["4ZBR_A_ACTA608_0","SERUM ALBUMIN","3d89","RIESKE DOMAIN-CONTAINING PROTEIN","Mus musculus",3,"LYS A  14;ARG A  39;HIS A 120","None","1.26A","4zbrA-3d89A:undetectable","4zbrA-3d89A:14.01"],["5F8Y_A_X6XA202_1","GALNAC\/GAL-SPECIFIC LECTIN","3d89","RIESKE DOMAIN-CONTAINING PROTEIN","Mus musculus",4,"HIS A  59;GLY A  62;GLY A  61;HIS A  83","FES A 201 (-3.1A);FES A 201 (-3.9A);FES A 201 ( 4.6A);FES A 201 (-3.2A)","0.76A","5f8yA-3d89A:undetectable","5f8yA-3d89A:22.78"],["5F8Y_B_X6XB201_1","GALNAC\/GAL-SPECIFIC LECTIN","3d89","RIESKE DOMAIN-CONTAINING PROTEIN","Mus musculus",4,"HIS A  59;GLY A  62;GLY A  61;HIS A  83","FES A 201 (-3.1A);FES A 201 (-3.9A);FES A 201 ( 4.6A);FES A 201 (-3.2A)","0.72A","5f8yB-3d89A:undetectable","5f8yB-3d89A:22.78"]]