SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d8b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 3d8b FIDGETIN-LIKE
PROTEIN 1
(Homo
sapiens) 		5 / 9 GLY A 543
ILE A 539
PRO A 433
VAL A 417
ILE A 437
 None
 1.09A 1hxwA-3d8bA:
undetectable		 1hxwA-3d8bA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 3d8b FIDGETIN-LIKE
PROTEIN 1
(Homo
sapiens) 		4 / 8 LEU A 376
LYS A 480
GLU A 477
ALA A 484
 None
 0.83A 1ie4B-3d8bA:
undetectable
1ie4D-3d8bA:
undetectable		 1ie4B-3d8bA:
15.04
1ie4D-3d8bA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3d8b FIDGETIN-LIKE
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A 451
LEU A 540
ILE A 437
ILE A 565
LEU A 563
 None
 1.11A 1kyvA-3d8bA:
undetectable
1kyvE-3d8bA:
undetectable		 1kyvA-3d8bA:
19.43
1kyvE-3d8bA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3d8b FIDGETIN-LIKE
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 565
LEU A 563
GLY A 451
LEU A 540
ILE A 437
 None
 1.12A 1kyvB-3d8bA:
undetectable
1kyvC-3d8bA:
undetectable		 1kyvB-3d8bA:
19.43
1kyvC-3d8bA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3d8b FIDGETIN-LIKE
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 565
LEU A 563
GLY A 451
LEU A 540
ILE A 437
 None
 1.13A 1kyvC-3d8bA:
undetectable
1kyvD-3d8bA:
undetectable		 1kyvC-3d8bA:
19.43
1kyvD-3d8bA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3d8b FIDGETIN-LIKE
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 565
LEU A 563
GLY A 451
LEU A 540
ILE A 437
 None
 1.10A 1kyvD-3d8bA:
undetectable
1kyvE-3d8bA:
undetectable		 1kyvD-3d8bA:
19.43
1kyvE-3d8bA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 3d8b FIDGETIN-LIKE
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 485
PHE A 486
ILE A 499
ALA A 467
THR A 471
 None
 1.28A 2v0mC-3d8bA:
undetectable		 2v0mC-3d8bA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 3d8b FIDGETIN-LIKE
PROTEIN 1
(Homo
sapiens) 		4 / 6 ILE A 416
MET A 421
PRO A 420
VAL A 482
 None
 1.12A 2ygoA-3d8bA:
undetectable		 2ygoA-3d8bA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3d8b FIDGETIN-LIKE
PROTEIN 1
(Homo
sapiens) 		3 / 3 GLY A 444
GLY A 446
THR A 448
 ADP  A 900 (-3.5A)
ADP  A 900 (-3.2A)
ADP  A 900 (-3.8A)
 0.46A 3si7B-3d8bA:
4.2		 3si7B-3d8bA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 3d8b FIDGETIN-LIKE
PROTEIN 1
(Homo
sapiens) 		4 / 6 THR A 445
GLY A 605
ILE A 576
LEU A 449
 ADP  A 900 (-4.3A)
ADP  A 900 (-3.7A)
ADP  A 900 ( 4.7A)
ADP  A 900 (-4.0A)
 1.13A 4ac9C-3d8bA:
undetectable		 4ac9C-3d8bA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3d8b FIDGETIN-LIKE
PROTEIN 1
(Homo
sapiens) 		4 / 6 THR A 445
GLY A 605
ILE A 576
LEU A 449
 ADP  A 900 (-4.3A)
ADP  A 900 (-3.7A)
ADP  A 900 ( 4.7A)
ADP  A 900 (-4.0A)
 1.12A 4acaC-3d8bA:
undetectable		 4acaC-3d8bA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3d8b FIDGETIN-LIKE
PROTEIN 1
(Homo
sapiens) 		4 / 8 GLY A 405
ILE A 403
ILE A 565
THR A 445
 None
None
None
ADP  A 900 (-4.3A)
 0.74A 4em2A-3d8bA:
undetectable		 4em2A-3d8bA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 3d8b FIDGETIN-LIKE
PROTEIN 1
(Homo
sapiens) 		4 / 4 VAL A 526
THR A 522
GLU A 523
GLU A 479
 None
 1.39A 4l78A-3d8bA:
undetectable		 4l78A-3d8bA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3d8b FIDGETIN-LIKE
PROTEIN 1
(Homo
sapiens) 		4 / 7 PHE A 486
ILE A 539
PHE A 524
LEU A 559
 None
 0.89A 4zdzA-3d8bA:
undetectable		 4zdzA-3d8bA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3d8b FIDGETIN-LIKE
PROTEIN 1
(Homo
sapiens) 		4 / 7 PHE A 486
ILE A 539
PHE A 524
LEU A 559
 None
 0.83A 4ze3A-3d8bA:
undetectable		 4ze3A-3d8bA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3d8b FIDGETIN-LIKE
PROTEIN 1
(Homo
sapiens) 		4 / 8 PHE A 486
ILE A 539
PHE A 524
LEU A 559
 None
 0.87A 5esfA-3d8bA:
undetectable		 5esfA-3d8bA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3d8b FIDGETIN-LIKE
PROTEIN 1
(Homo
sapiens) 		4 / 8 PHE A 486
ILE A 539
PHE A 524
LEU A 559
 None
 0.76A 5esjA-3d8bA:
undetectable		 5esjA-3d8bA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3d8b FIDGETIN-LIKE
PROTEIN 1
(Homo
sapiens) 		4 / 7 PHE A 486
ILE A 539
PHE A 524
LEU A 559
 None
 0.86A 5esmA-3d8bA:
undetectable		 5esmA-3d8bA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 3d8b FIDGETIN-LIKE
PROTEIN 1
(Homo
sapiens) 		5 / 12 MET A 608
LEU A 611
ARG A 649
PHE A 648
LEU A 588
 None
 1.43A 5uc3B-3d8bA:
undetectable		 5uc3B-3d8bA:
14.04