SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d8d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TH6_A_OINA401_1
(PHOSPHOLIPASE A2)		 3d8d AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 1
(Homo
sapiens) 		4 / 7 GLY A 414
TRP A 416
HIS A 409
ASP A 410
 None
 1.14A 1th6A-3d8dA:
undetectable		 1th6A-3d8dA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ARM_A_OINA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3d8d AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 1
(Homo
sapiens) 		4 / 7 GLY A 414
TRP A 416
HIS A 409
ASP A 410
 None
 1.13A 2armA-3d8dA:
undetectable		 2armA-3d8dA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 3d8d AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 1
(Homo
sapiens) 		3 / 3 GLN A 445
THR A 474
TRP A 377
 None
 1.15A 2rctA-3d8dA:
2.1		 2rctA-3d8dA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 3d8d AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 1
(Homo
sapiens) 		5 / 11 PHE A 370
LEU A 424
PHE A 465
LEU A 426
SER A 494
 None
 1.48A 3o94B-3d8dA:
undetectable		 3o94B-3d8dA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 3d8d AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 1
(Homo
sapiens) 		5 / 11 PHE A 370
LEU A 424
PHE A 465
LEU A 426
SER A 494
 None
 1.46A 3o94C-3d8dA:
undetectable		 3o94C-3d8dA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 3d8d AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 1
(Homo
sapiens) 		3 / 3 ARG A 470
GLU A 379
ARG A 451
 None
 0.98A 4mwvA-3d8dA:
undetectable		 4mwvA-3d8dA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 3d8d AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 1
(Homo
sapiens) 		3 / 3 ARG A 483
ASP A 464
TYR A 403
 None
 0.91A 4yo9B-3d8dA:
undetectable		 4yo9B-3d8dA:
19.11