SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d8h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 3d8h GLYCOLYTIC
PHOSPHOGLYCERATE
MUTASE
(Cryptosporidium
parvum) 		5 / 12 VAL A 241
LEU A 235
LEU A 208
LEU A 212
LEU A 205
 None
 1.08A 1mx1C-3d8hA:
undetectable		 1mx1C-3d8hA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 3d8h GLYCOLYTIC
PHOSPHOGLYCERATE
MUTASE
(Cryptosporidium
parvum) 		5 / 11 GLY A 202
SER A 204
ALA A  80
LEU A  77
VAL A 198
 None
 1.00A 1ukbA-3d8hA:
undetectable		 1ukbA-3d8hA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 3d8h GLYCOLYTIC
PHOSPHOGLYCERATE
MUTASE
(Cryptosporidium
parvum) 		5 / 12 ALA A  80
GLY A  41
SER A  75
LEU A 104
SER A 204
 None
 0.95A 3gyqA-3d8hA:
undetectable
3gyqB-3d8hA:
undetectable		 3gyqA-3d8hA:
23.38
3gyqB-3d8hA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 3d8h GLYCOLYTIC
PHOSPHOGLYCERATE
MUTASE
(Cryptosporidium
parvum) 		4 / 7 ILE A  26
LEU A 104
VAL A 185
SER A 189
 None
 0.97A 3r9vA-3d8hA:
undetectable
3r9vB-3d8hA:
undetectable		 3r9vA-3d8hA:
23.79
3r9vB-3d8hA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3d8h GLYCOLYTIC
PHOSPHOGLYCERATE
MUTASE
(Cryptosporidium
parvum) 		5 / 11 THR A  84
ALA A  80
ASN A 100
VAL A 185
ILE A  99
 None
 1.40A 4claA-3d8hA:
undetectable		 4claA-3d8hA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 3d8h GLYCOLYTIC
PHOSPHOGLYCERATE
MUTASE
(Cryptosporidium
parvum) 		5 / 11 LEU A 208
ALA A 200
THR A  84
ILE A  98
VAL A  71
 None
 1.01A 4h1nA-3d8hA:
undetectable		 4h1nA-3d8hA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3d8h GLYCOLYTIC
PHOSPHOGLYCERATE
MUTASE
(Cryptosporidium
parvum) 		4 / 9 SER A 122
ALA A 121
LEU A 115
LEU A 112
 None
 1.00A 4xtaA-3d8hA:
undetectable		 4xtaA-3d8hA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 3d8h GLYCOLYTIC
PHOSPHOGLYCERATE
MUTASE
(Cryptosporidium
parvum) 		5 / 12 LEU A 197
LEU A 104
ALA A 200
LEU A  25
ILE A 186
 None
 1.08A 5itzB-3d8hA:
undetectable		 5itzB-3d8hA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_D_MMSD515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3d8h GLYCOLYTIC
PHOSPHOGLYCERATE
MUTASE
(Cryptosporidium
parvum) 		5 / 9 HIS A  28
HIS A 201
LEU A 205
THR A  74
SER A  75
 None
 1.26A 5m8nD-3d8hA:
0.0		 5m8nD-3d8hA:
20.91