SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d8k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3d8k PROTEIN PHOSPHATASE
2C
(Toxoplasma
gondii) 		5 / 12 THR A 330
ASP A 328
GLY A 249
HIS A 268
PHE A 164
 None
 1.20A 1v8bD-3d8kA:
undetectable		 1v8bD-3d8kA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 3d8k PROTEIN PHOSPHATASE
2C
(Toxoplasma
gondii) 		5 / 12 VAL A 187
GLU A 114
GLY A 115
ASN A 150
GLN A 143
 None
 1.43A 1vidA-3d8kA:
undetectable		 1vidA-3d8kA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3d8k PROTEIN PHOSPHATASE
2C
(Toxoplasma
gondii) 		3 / 3 LYS A 311
ASP A 151
ASP A 168
 None
 0.74A 2br4D-3d8kA:
undetectable		 2br4D-3d8kA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3d8k PROTEIN PHOSPHATASE
2C
(Toxoplasma
gondii) 		3 / 3 LEU A 218
LEU A 222
MET A 223
 None
 0.71A 2itzA-3d8kA:
undetectable		 2itzA-3d8kA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 3d8k PROTEIN PHOSPHATASE
2C
(Toxoplasma
gondii) 		5 / 9 GLY A 131
SER A 180
LEU A 141
SER A 181
ASP A 130
 None
 1.18A 2j2pB-3d8kA:
undetectable
2j2pC-3d8kA:
undetectable		 2j2pB-3d8kA:
20.73
2j2pC-3d8kA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 3d8k PROTEIN PHOSPHATASE
2C
(Toxoplasma
gondii) 		4 / 6 SER A 180
LEU A 141
SER A 181
ASP A 130
 None
 1.14A 2j2pE-3d8kA:
undetectable
2j2pF-3d8kA:
undetectable		 2j2pE-3d8kA:
20.73
2j2pF-3d8kA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3d8k PROTEIN PHOSPHATASE
2C
(Toxoplasma
gondii) 		5 / 12 THR A 330
ASP A 328
GLY A 249
HIS A 268
PHE A 164
 None
 1.22A 3g1uD-3d8kA:
undetectable		 3g1uD-3d8kA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3d8k PROTEIN PHOSPHATASE
2C
(Toxoplasma
gondii) 		5 / 12 GLY A 343
VAL A 341
ALA A 345
GLY A 346
ILE A 357
 None
 1.10A 3ku1G-3d8kA:
undetectable		 3ku1G-3d8kA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 3d8k PROTEIN PHOSPHATASE
2C
(Toxoplasma
gondii) 		5 / 11 ALA A 261
THR A 260
ALA A 362
VAL A 254
ALA A 215
 None
 0.82A 3mg0K-3d8kA:
4.3
3mg0L-3d8kA:
undetectable		 3mg0K-3d8kA:
19.69
3mg0L-3d8kA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 3d8k PROTEIN PHOSPHATASE
2C
(Toxoplasma
gondii) 		5 / 12 ALA A 261
THR A 260
ALA A 362
VAL A 254
ALA A 215
 None
 0.81A 3mg0Y-3d8kA:
undetectable
3mg0Z-3d8kA:
4.7		 3mg0Y-3d8kA:
19.69
3mg0Z-3d8kA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3d8k PROTEIN PHOSPHATASE
2C
(Toxoplasma
gondii) 		5 / 12 THR A 330
ASP A 328
GLY A 249
HIS A 268
PHE A 164
 None
 1.21A 3n58C-3d8kA:
undetectable		 3n58C-3d8kA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3d8k PROTEIN PHOSPHATASE
2C
(Toxoplasma
gondii) 		4 / 6 ARG A 172
PHE A 308
ALA A 174
ALA A 173
 None
 1.13A 3ns1C-3d8kA:
undetectable		 3ns1C-3d8kA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 3d8k PROTEIN PHOSPHATASE
2C
(Toxoplasma
gondii) 		5 / 12 THR A 330
ASP A 328
GLY A 249
HIS A 268
PHE A 164
 None
 1.27A 3ondA-3d8kA:
undetectable		 3ondA-3d8kA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 3d8k PROTEIN PHOSPHATASE
2C
(Toxoplasma
gondii) 		5 / 12 THR A 330
ASP A 328
GLY A 249
HIS A 268
PHE A 164
 None
 1.25A 3ondB-3d8kA:
undetectable		 3ondB-3d8kA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 3d8k PROTEIN PHOSPHATASE
2C
(Toxoplasma
gondii) 		5 / 11 ALA A 334
VAL A 187
VAL A 341
VAL A 245
ILE A 243
 None
 1.09A 3oxvD-3d8kA:
undetectable		 3oxvD-3d8kA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 3d8k PROTEIN PHOSPHATASE
2C
(Toxoplasma
gondii) 		5 / 11 PHE A 351
ALA A 356
ALA A 359
ALA A 358
VAL A 341
 None
 1.01A 4j6cA-3d8kA:
undetectable		 4j6cA-3d8kA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 3d8k PROTEIN PHOSPHATASE
2C
(Toxoplasma
gondii) 		5 / 12 PHE A 351
ALA A 356
ALA A 359
ALA A 358
VAL A 341
 None
 1.02A 4j6dA-3d8kA:
undetectable		 4j6dA-3d8kA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 3d8k PROTEIN PHOSPHATASE
2C
(Toxoplasma
gondii) 		5 / 12 PHE A 351
ALA A 356
ALA A 359
ALA A 358
VAL A 341
 None
 1.01A 4j6dB-3d8kA:
undetectable		 4j6dB-3d8kA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 3d8k PROTEIN PHOSPHATASE
2C
(Toxoplasma
gondii) 		5 / 12 PHE A 351
ALA A 356
ALA A 359
ALA A 358
VAL A 341
 None
 1.02A 4jbtA-3d8kA:
undetectable		 4jbtA-3d8kA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 3d8k PROTEIN PHOSPHATASE
2C
(Toxoplasma
gondii) 		5 / 11 PHE A 351
ALA A 356
ALA A 359
ALA A 358
VAL A 341
 None
 1.02A 4jbtB-3d8kA:
undetectable		 4jbtB-3d8kA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3d8k PROTEIN PHOSPHATASE
2C
(Toxoplasma
gondii) 		4 / 8 SER A 405
GLU A 114
ASP A 424
TYR A 189
 None
 1.16A 4qb9D-3d8kA:
undetectable		 4qb9D-3d8kA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3d8k PROTEIN PHOSPHATASE
2C
(Toxoplasma
gondii) 		5 / 12 VAL A 187
GLU A 114
GLY A 115
ASN A 150
GLN A 143
 None
 1.37A 5fhrA-3d8kA:
undetectable		 5fhrA-3d8kA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 3d8k PROTEIN PHOSPHATASE
2C
(Toxoplasma
gondii) 		3 / 3 VAL A 111
GLU A  84
GLU A 410
 None
 0.93A 5jsdB-3d8kA:
0.0
5jsdC-3d8kA:
0.0		 5jsdB-3d8kA:
20.25
5jsdC-3d8kA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3d8k PROTEIN PHOSPHATASE
2C
(Toxoplasma
gondii) 		4 / 8 LEU A 398
ILE A 340
ARG A 396
PRO A 193
 None
 0.89A 5m0oC-3d8kA:
undetectable		 5m0oC-3d8kA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3d8k PROTEIN PHOSPHATASE
2C
(Toxoplasma
gondii) 		5 / 12 THR A 330
ASP A 328
GLY A 249
HIS A 268
PHE A 164
 None
 1.25A 5m66A-3d8kA:
undetectable		 5m66A-3d8kA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3d8k PROTEIN PHOSPHATASE
2C
(Toxoplasma
gondii) 		5 / 12 THR A 330
ASP A 328
GLY A 249
HIS A 268
PHE A 164
 None
 1.25A 5m66C-3d8kA:
undetectable		 5m66C-3d8kA:
21.35