SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d8m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3d8m BASEPLATE PROTEIN,
RECEPTOR BINDING
PROTEIN
(Lactococcus
phage
TP901-1;
Lactococcus
virus
P2) 		5 / 12 ASN A 159
PHE A  91
THR A  80
VAL A  87
LEU A  86
 None
 1.49A 2xrlA-3d8mA:
undetectable		 2xrlA-3d8mA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3d8m BASEPLATE PROTEIN,
RECEPTOR BINDING
PROTEIN
(Lactococcus
phage
TP901-1;
Lactococcus
virus
P2) 		4 / 6 THR A 143
ILE A 142
THR A 156
PHE A  91
 None
 0.96A 4acbC-3d8mA:
undetectable		 4acbC-3d8mA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 3d8m BASEPLATE PROTEIN,
RECEPTOR BINDING
PROTEIN
(Lactococcus
phage
TP901-1;
Lactococcus
virus
P2) 		4 / 8 GLN A  78
THR A  68
THR A  80
ARG A  90
 None
 0.94A 4k87A-3d8mA:
undetectable		 4k87A-3d8mA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 3d8m BASEPLATE PROTEIN,
RECEPTOR BINDING
PROTEIN
(Lactococcus
phage
TP901-1;
Lactococcus
virus
P2) 		5 / 12 PHE A 132
TYR A 162
ILE A  88
PHE A  91
LEU A  77
 None
 1.43A 4kotA-3d8mA:
undetectable		 4kotA-3d8mA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 3d8m BASEPLATE PROTEIN,
RECEPTOR BINDING
PROTEIN
(Lactococcus
phage
TP901-1;
Lactococcus
virus
P2) 		5 / 9 ASN A 159
ILE A 136
ILE A 134
VAL A 109
ILE A 142
 None
 1.38A 6hloA-3d8mA:
undetectable		 6hloA-3d8mA:
14.45