SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d8p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 3d8p ACETYLTRANSFERASE OF
GNAT FAMILY
(Staphylococcus
aureus) 		4 / 8 TRP A  55
LEU A  99
GLY A  95
LEU A  80
 None
None
EDO  A 168 ( 4.4A)
EDO  A 167 (-4.4A)
 0.68A 1ya4A-3d8pA:
undetectable		 1ya4A-3d8pA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 3d8p ACETYLTRANSFERASE OF
GNAT FAMILY
(Staphylococcus
aureus) 		4 / 7 TRP A  55
LEU A  99
GLY A  95
LEU A  80
 None
None
EDO  A 168 ( 4.4A)
EDO  A 167 (-4.4A)
 0.68A 1ya4B-3d8pA:
undetectable		 1ya4B-3d8pA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3d8p ACETYLTRANSFERASE OF
GNAT FAMILY
(Staphylococcus
aureus) 		5 / 12 PHE A 146
ASP A  39
ILE A  43
LEU A  16
GLY A  69
 None
 1.24A 2e7fA-3d8pA:
undetectable		 2e7fA-3d8pA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3d8p ACETYLTRANSFERASE OF
GNAT FAMILY
(Staphylococcus
aureus) 		5 / 12 PHE A 146
ASP A  39
ILE A  43
LEU A  16
GLY A  69
 None
 1.21A 2ogyA-3d8pA:
undetectable		 2ogyA-3d8pA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3d8p ACETYLTRANSFERASE OF
GNAT FAMILY
(Staphylococcus
aureus) 		5 / 12 PHE A 146
ASP A  39
ILE A  43
LEU A  16
GLY A  69
 None
 1.29A 2ogyB-3d8pA:
undetectable		 2ogyB-3d8pA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3d8p ACETYLTRANSFERASE OF
GNAT FAMILY
(Staphylococcus
aureus) 		5 / 12 PHE A 146
ASP A  39
ILE A  43
LEU A  16
GLY A  69
 None
 1.27A 2ycjA-3d8pA:
undetectable		 2ycjA-3d8pA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3d8p ACETYLTRANSFERASE OF
GNAT FAMILY
(Staphylococcus
aureus) 		5 / 12 PHE A 146
ASP A  39
ILE A  43
LEU A  16
GLY A  69
 None
 1.28A 4djfB-3d8pA:
undetectable		 4djfB-3d8pA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 3d8p ACETYLTRANSFERASE OF
GNAT FAMILY
(Staphylococcus
aureus) 		5 / 11 ILE A  71
TYR A  47
ILE A  43
ILE A  30
ILE A  32
 None
 1.12A 5hw8A-3d8pA:
undetectable
5hw8D-3d8pA:
undetectable		 5hw8A-3d8pA:
25.83
5hw8D-3d8pA:
25.83