SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d8u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3d8u PURR TRANSCRIPTIONAL
REGULATOR
(Vibrio
parahaemolyticus) 		4 / 7 LEU A 132
HIS A 137
THR A 150
TYR A 164
 None
 1.29A 1afsA-3d8uA:
undetectable		 1afsA-3d8uA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3d8u PURR TRANSCRIPTIONAL
REGULATOR
(Vibrio
parahaemolyticus) 		4 / 7 LEU A 132
HIS A 137
THR A 150
TYR A 164
 None
 1.29A 1afsB-3d8uA:
undetectable		 1afsB-3d8uA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3d8u PURR TRANSCRIPTIONAL
REGULATOR
(Vibrio
parahaemolyticus) 		5 / 12 ALA A 311
ALA A 310
LEU A  96
ALA A  95
ILE A  76
 None
 0.79A 1fm6U-3d8uA:
undetectable		 1fm6U-3d8uA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3d8u PURR TRANSCRIPTIONAL
REGULATOR
(Vibrio
parahaemolyticus) 		4 / 7 LEU A 103
PHE A 122
LEU A  89
SER A 108
 None
 0.77A 1wrlE-3d8uA:
undetectable
1wrlF-3d8uA:
undetectable		 1wrlE-3d8uA:
15.30
1wrlF-3d8uA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 3d8u PURR TRANSCRIPTIONAL
REGULATOR
(Vibrio
parahaemolyticus) 		4 / 6 LEU A  75
LEU A 315
LEU A 153
ILE A 318
 None
 0.92A 1z95A-3d8uA:
undetectable		 1z95A-3d8uA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3d8u PURR TRANSCRIPTIONAL
REGULATOR
(Vibrio
parahaemolyticus) 		5 / 12 ALA A 311
ALA A 310
LEU A  96
ALA A  95
ILE A  76
 None
 0.96A 2aclA-3d8uA:
undetectable
2aclE-3d8uA:
undetectable		 2aclA-3d8uA:
25.62
2aclE-3d8uA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 3d8u PURR TRANSCRIPTIONAL
REGULATOR
(Vibrio
parahaemolyticus) 		5 / 12 LEU A 272
LEU A 249
LEU A 243
GLY A 191
LEU A 252
 None
 1.07A 2ouzA-3d8uA:
undetectable		 2ouzA-3d8uA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3d8u PURR TRANSCRIPTIONAL
REGULATOR
(Vibrio
parahaemolyticus) 		5 / 12 GLN A 185
ALA A 251
THR A 339
GLY A 186
LEU A 218
 None
 1.47A 3aobC-3d8uA:
undetectable		 3aobC-3d8uA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3d8u PURR TRANSCRIPTIONAL
REGULATOR
(Vibrio
parahaemolyticus) 		5 / 10 ALA A 311
ALA A 310
LEU A  96
ALA A  95
ILE A  76
 None
 0.86A 3falC-3d8uA:
undetectable		 3falC-3d8uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3d8u PURR TRANSCRIPTIONAL
REGULATOR
(Vibrio
parahaemolyticus) 		5 / 10 ALA A 311
ALA A 310
LEU A  96
ALA A  95
ILE A  77
 None
 1.04A 3falC-3d8uA:
undetectable		 3falC-3d8uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3d8u PURR TRANSCRIPTIONAL
REGULATOR
(Vibrio
parahaemolyticus) 		5 / 11 ALA A 311
ALA A 310
LEU A  96
ALA A  95
ILE A  76
 None
 0.86A 3fc6A-3d8uA:
undetectable		 3fc6A-3d8uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3d8u PURR TRANSCRIPTIONAL
REGULATOR
(Vibrio
parahaemolyticus) 		5 / 12 VAL A 130
ALA A 311
ALA A 310
LEU A  96
ALA A  95
 None
 0.83A 3fc6C-3d8uA:
undetectable		 3fc6C-3d8uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 3d8u PURR TRANSCRIPTIONAL
REGULATOR
(Vibrio
parahaemolyticus) 		4 / 8 PHE A 133
LEU A 105
PHE A  88
LEU A  89
 None
 1.03A 3i45A-3d8uA:
16.8		 3i45A-3d8uA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3d8u PURR TRANSCRIPTIONAL
REGULATOR
(Vibrio
parahaemolyticus) 		5 / 12 ALA A 311
ALA A 310
LEU A  96
ALA A  95
ILE A  76
 None
 0.76A 3oapA-3d8uA:
undetectable		 3oapA-3d8uA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3d8u PURR TRANSCRIPTIONAL
REGULATOR
(Vibrio
parahaemolyticus) 		4 / 7 ILE A  76
GLY A 106
PHE A  92
LEU A 103
 None
 0.75A 3v7pA-3d8uA:
undetectable		 3v7pA-3d8uA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 3d8u PURR TRANSCRIPTIONAL
REGULATOR
(Vibrio
parahaemolyticus) 		5 / 12 LEU A  89
LEU A 315
LEU A 314
ALA A  95
ALA A  99
 None
 1.12A 3vw7A-3d8uA:
undetectable		 3vw7A-3d8uA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1224_0
(THAUMATIN-LIKE
PROTEIN)		 3d8u PURR TRANSCRIPTIONAL
REGULATOR
(Vibrio
parahaemolyticus) 		4 / 5 SER A  91
GLU A 304
THR A 308
ASP A 302
 None
 1.48A 3zs3A-3d8uA:
0.0		 3zs3A-3d8uA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 3d8u PURR TRANSCRIPTIONAL
REGULATOR
(Vibrio
parahaemolyticus) 		5 / 12 ILE A 155
GLY A 134
ALA A 156
TYR A 110
GLU A  82
 None
 1.06A 4xt8A-3d8uA:
undetectable		 4xt8A-3d8uA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 3d8u PURR TRANSCRIPTIONAL
REGULATOR
(Vibrio
parahaemolyticus) 		3 / 3 ILE A 261
ILE A 280
MET A 288
 None
 0.70A 5i9yA-3d8uA:
undetectable		 5i9yA-3d8uA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3d8u PURR TRANSCRIPTIONAL
REGULATOR
(Vibrio
parahaemolyticus) 		5 / 12 ILE A 193
GLY A 238
GLU A 284
ALA A 251
ILE A 261
 None
 1.05A 5igvA-3d8uA:
undetectable		 5igvA-3d8uA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3d8u PURR TRANSCRIPTIONAL
REGULATOR
(Vibrio
parahaemolyticus) 		5 / 12 ALA A 311
ALA A 310
LEU A  96
ALA A  95
ILE A  76
 None
 0.87A 6a5yD-3d8uA:
undetectable		 6a5yD-3d8uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3d8u PURR TRANSCRIPTIONAL
REGULATOR
(Vibrio
parahaemolyticus) 		5 / 12 ALA A 311
ALA A 310
LEU A  96
ALA A  95
ILE A  77
 None
 0.89A 6a5yD-3d8uA:
undetectable		 6a5yD-3d8uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3d8u PURR TRANSCRIPTIONAL
REGULATOR
(Vibrio
parahaemolyticus) 		5 / 12 ALA A 311
ALA A 310
LEU A  96
ALA A  95
ILE A  76
 None
 0.84A 6a5zD-3d8uA:
undetectable		 6a5zD-3d8uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3d8u PURR TRANSCRIPTIONAL
REGULATOR
(Vibrio
parahaemolyticus) 		5 / 12 ALA A 311
ALA A 310
LEU A  96
ALA A  95
ILE A  76
 None
 0.84A 6a5zL-3d8uA:
undetectable		 6a5zL-3d8uA:
13.65