SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3d8x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 138
ALA A 216
THR A 133
ILE A 139
GLY A 220
 None
 0.98A 1c9sN-3d8xA:
undetectable
1c9sO-3d8xA:
undetectable		 1c9sN-3d8xA:
13.12
1c9sO-3d8xA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 138
ALA A 216
THR A 133
ILE A 139
GLY A 220
 None
 0.98A 1c9sP-3d8xA:
undetectable
1c9sQ-3d8xA:
undetectable		 1c9sP-3d8xA:
13.12
1c9sQ-3d8xA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 138
ALA A 216
THR A 133
ILE A 139
GLY A 220
 None
 0.99A 1c9sQ-3d8xA:
undetectable
1c9sR-3d8xA:
undetectable		 1c9sQ-3d8xA:
13.12
1c9sR-3d8xA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 220
GLY A 138
ALA A 216
THR A 133
ILE A 139
 None
 0.96A 1c9sL-3d8xA:
undetectable
1c9sV-3d8xA:
undetectable		 1c9sL-3d8xA:
13.12
1c9sV-3d8xA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 213
LEU A 183
LEU A 226
ALA A 158
 None
 0.67A 1e7cA-3d8xA:
undetectable		 1e7cA-3d8xA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 220
GLY A 138
ALA A 216
THR A 133
ILE A 139
 None
 0.99A 1gtfD-3d8xA:
undetectable
1gtfE-3d8xA:
undetectable		 1gtfD-3d8xA:
13.12
1gtfE-3d8xA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 220
GLY A 138
ALA A 216
THR A 133
ILE A 139
 None
 1.01A 1gtfJ-3d8xA:
undetectable
1gtfK-3d8xA:
undetectable		 1gtfJ-3d8xA:
13.12
1gtfK-3d8xA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 138
ALA A 216
THR A 133
ILE A 139
GLY A 220
 None
 0.99A 1gtfQ-3d8xA:
undetectable
1gtfR-3d8xA:
undetectable		 1gtfQ-3d8xA:
13.12
1gtfR-3d8xA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 138
ALA A 216
THR A 133
ILE A 139
GLY A 220
 None
 0.98A 1gtfR-3d8xA:
undetectable
1gtfS-3d8xA:
undetectable		 1gtfR-3d8xA:
13.12
1gtfS-3d8xA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 138
ALA A 216
THR A 133
ILE A 139
GLY A 220
 None
 0.98A 1gtfS-3d8xA:
undetectable
1gtfT-3d8xA:
undetectable		 1gtfS-3d8xA:
13.12
1gtfT-3d8xA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 138
ALA A 216
THR A 133
ILE A 139
GLY A 220
 None
 0.99A 1gtnT-3d8xA:
undetectable
1gtnU-3d8xA:
undetectable		 1gtnT-3d8xA:
13.12
1gtnU-3d8xA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 220
GLY A 138
ALA A 216
THR A 133
ILE A 139
 None
 1.00A 1gtnL-3d8xA:
undetectable
1gtnV-3d8xA:
undetectable		 1gtnL-3d8xA:
13.12
1gtnV-3d8xA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A   8
ILE A   9
TYR A  32
GLU A  81
THR A 112
 None
FAD  A1001 (-4.7A)
None
None
None
 1.26A 1jtxA-3d8xA:
undetectable		 1jtxA-3d8xA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 138
ALA A 216
THR A 133
ILE A 139
GLY A 220
 None
 0.99A 1utdH-3d8xA:
undetectable
1utdI-3d8xA:
undetectable		 1utdH-3d8xA:
13.12
1utdI-3d8xA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 138
ALA A 216
THR A 133
ILE A 139
GLY A 220
 None
 0.99A 1utdL-3d8xA:
undetectable
1utdM-3d8xA:
undetectable		 1utdL-3d8xA:
13.12
1utdM-3d8xA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 138
ALA A 216
THR A 133
ILE A 139
GLY A 220
 None
 1.00A 1utdO-3d8xA:
undetectable
1utdP-3d8xA:
undetectable		 1utdO-3d8xA:
13.12
1utdP-3d8xA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 138
ALA A 216
THR A 133
ILE A 139
GLY A 220
 None
 1.00A 1utdP-3d8xA:
undetectable
1utdQ-3d8xA:
undetectable		 1utdP-3d8xA:
13.12
1utdQ-3d8xA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 138
ALA A 216
THR A 133
ILE A 139
GLY A 220
 None
 1.00A 1utdS-3d8xA:
undetectable
1utdT-3d8xA:
undetectable		 1utdS-3d8xA:
13.12
1utdT-3d8xA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 138
ALA A 216
THR A 133
ILE A 139
GLY A 220
 None
 0.98A 1utdU-3d8xA:
undetectable
1utdV-3d8xA:
undetectable		 1utdU-3d8xA:
13.12
1utdV-3d8xA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 220
GLY A 138
ALA A 216
THR A 133
ILE A 139
 None
 1.01A 1utdL-3d8xA:
undetectable
1utdV-3d8xA:
undetectable		 1utdL-3d8xA:
13.12
1utdV-3d8xA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 264
TYR A 268
LYS A 293
 None
 1.18A 2othA-3d8xA:
undetectable		 2othA-3d8xA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		4 / 8 GLY A  44
ILE A 256
SER A  11
THR A  86
 FAD  A1001 (-3.1A)
FAD  A1001 ( 4.7A)
FAD  A1001 (-4.5A)
FAD  A1001 (-4.1A)
 0.80A 2yoeB-3d8xA:
undetectable
2yoeC-3d8xA:
undetectable		 2yoeB-3d8xA:
20.11
2yoeC-3d8xA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 287
ASP A 291
ALA A 301
GLY A 302
ILE A 116
 FAD  A1001 (-3.5A)
None
None
None
None
 0.95A 3ku1C-3d8xA:
5.2		 3ku1C-3d8xA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 287
ALA A 286
GLY A  10
ALA A 301
ILE A   8
 FAD  A1001 (-3.5A)
None
FAD  A1001 (-3.5A)
None
None
 1.17A 3n3iA-3d8xA:
undetectable		 3n3iA-3d8xA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		4 / 7 PRO A  56
LEU A  67
LEU A  46
ILE A 298
 None
None
FAD  A1001 (-4.3A)
None
 1.01A 3u5jA-3d8xA:
undetectable		 3u5jA-3d8xA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		3 / 3 THR A 101
ASN A 104
GLU A  85
 None
 0.81A 3v4tA-3d8xA:
undetectable
3v4tC-3d8xA:
1.1		 3v4tA-3d8xA:
22.79
3v4tC-3d8xA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		4 / 7 ARG A  72
GLY A  43
THR A  84
GLU A  33
 None
 0.83A 5bs8A-3d8xA:
undetectable
5bs8C-3d8xA:
undetectable
5bs8D-3d8xA:
undetectable		 5bs8A-3d8xA:
23.13
5bs8C-3d8xA:
23.13
5bs8D-3d8xA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		4 / 7 ARG A  72
GLY A  43
THR A  84
GLU A  33
 None
 0.85A 5bs8A-3d8xA:
undetectable
5bs8B-3d8xA:
undetectable
5bs8C-3d8xA:
undetectable		 5bs8A-3d8xA:
23.13
5bs8B-3d8xA:
23.60
5bs8C-3d8xA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		4 / 7 ARG A  72
GLY A  43
THR A  84
GLU A  33
 None
 0.81A 5btaA-3d8xA:
undetectable
5btaC-3d8xA:
undetectable
5btaD-3d8xA:
undetectable		 5btaA-3d8xA:
22.70
5btaC-3d8xA:
22.70
5btaD-3d8xA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		4 / 6 ARG A  72
GLY A  43
THR A  84
GLU A  33
 None
 0.83A 5btaA-3d8xA:
undetectable
5btaB-3d8xA:
undetectable
5btaC-3d8xA:
undetectable		 5btaA-3d8xA:
22.70
5btaB-3d8xA:
23.60
5btaC-3d8xA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		4 / 6 ARG A  72
GLY A  43
THR A  84
GLU A  33
 None
 0.78A 5btcA-3d8xA:
undetectable
5btcC-3d8xA:
undetectable
5btcD-3d8xA:
undetectable		 5btcA-3d8xA:
22.70
5btcC-3d8xA:
22.70
5btcD-3d8xA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		4 / 6 ARG A  72
GLY A  43
THR A  84
GLU A  33
 None
 0.81A 5btcA-3d8xA:
undetectable
5btcB-3d8xA:
undetectable
5btcC-3d8xA:
undetectable		 5btcA-3d8xA:
22.70
5btcB-3d8xA:
23.60
5btcC-3d8xA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		4 / 7 ARG A  72
GLY A  43
THR A  84
GLU A  33
 None
 0.82A 5btdA-3d8xA:
undetectable
5btdB-3d8xA:
undetectable
5btdC-3d8xA:
undetectable		 5btdA-3d8xA:
23.13
5btdB-3d8xA:
23.60
5btdC-3d8xA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		4 / 7 ARG A  72
GLY A  43
THR A  84
GLU A  33
 None
 0.80A 5btdA-3d8xA:
undetectable
5btdC-3d8xA:
undetectable
5btdD-3d8xA:
undetectable		 5btdA-3d8xA:
23.13
5btdC-3d8xA:
23.13
5btdD-3d8xA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		4 / 7 ARG A  72
GLY A  43
THR A  84
GLU A  33
 None
 0.82A 5btfA-3d8xA:
undetectable
5btfB-3d8xA:
undetectable
5btfC-3d8xA:
undetectable		 5btfA-3d8xA:
22.70
5btfB-3d8xA:
23.60
5btfC-3d8xA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		4 / 7 ARG A  72
GLY A  43
THR A  84
GLU A  33
 None
 0.83A 5btfA-3d8xA:
undetectable
5btfC-3d8xA:
undetectable
5btfD-3d8xA:
undetectable		 5btfA-3d8xA:
22.70
5btfC-3d8xA:
22.70
5btfD-3d8xA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		4 / 6 ARG A  72
GLY A  43
THR A  84
GLU A  33
 None
 0.91A 5btgA-3d8xA:
undetectable
5btgB-3d8xA:
undetectable
5btgC-3d8xA:
undetectable		 5btgA-3d8xA:
23.13
5btgB-3d8xA:
23.60
5btgC-3d8xA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		4 / 4 VAL A 257
ALA A 253
ILE A   9
THR A 119
 None
FAD  A1001 ( 4.4A)
FAD  A1001 (-4.7A)
FAD  A1001 (-3.9A)
 1.19A 5e4dB-3d8xA:
undetectable		 5e4dB-3d8xA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		3 / 3 MET A  71
GLN A  74
ARG A  70
 None
 1.09A 5ewzB-3d8xA:
undetectable		 5ewzB-3d8xA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		3 / 3 MET A  71
GLN A  74
ARG A  70
 None
 1.08A 5m35B-3d8xA:
undetectable		 5m35B-3d8xA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		3 / 3 MET A  71
GLN A  74
ARG A  70
 None
 1.09A 5m36A-3d8xA:
undetectable		 5m36A-3d8xA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 247
VAL A 149
GLN A 136
HIS A 250
 None
None
FAD  A1001 ( 4.6A)
None
 0.97A 5nu7A-3d8xA:
undetectable		 5nu7A-3d8xA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		4 / 5 HIS A  16
ALA A  42
SER A  11
GLY A  10
 None
None
FAD  A1001 (-4.5A)
FAD  A1001 (-3.5A)
 1.23A 5yodB-3d8xA:
undetectable		 5yodB-3d8xA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		3 / 3 MET A  71
GLN A  74
ARG A  70
 None
 1.06A 6fn9A-3d8xA:
undetectable		 6fn9A-3d8xA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		3 / 3 MET A  71
GLN A  74
ARG A  70
 None
 1.07A 6fnaB-3d8xA:
undetectable		 6fnaB-3d8xA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3d8x THIOREDOXIN
REDUCTASE 1
(Saccharomyces
cerevisiae) 		3 / 3 MET A  71
GLN A  74
ARG A  70
 None
 1.08A 6fnbA-3d8xA:
undetectable		 6fnbA-3d8xA:
21.71