SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3daf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 3daf 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 8 PHE A 162
ILE A 166
PHE A 183
LEU A   6
VAL A 139
 None
None
None
FEG  A 501 (-4.1A)
None
 1.34A 1fslA-3dafA:
undetectable		 1fslA-3dafA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 3daf 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A 337
ALA A 318
LEU A 315
THR A 317
 None
 1.08A 1ictB-3dafA:
undetectable		 1ictB-3dafA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 3daf 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanocaldococc
us
jannaschii) 		6 / 12 SER A  63
VAL A 145
ILE A 166
ILE A 159
PHE A 187
LEU A 149
 FEG  A 501 (-4.4A)
None
None
None
None
FEG  A 501 (-4.9A)
 1.37A 1qhsA-3dafA:
undetectable		 1qhsA-3dafA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 3daf 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 8 ALA A  25
ALA A  48
LEU A 121
VAL A 122
 None
 0.88A 2bxgA-3dafA:
3.7		 2bxgA-3dafA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 3daf 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A 337
ALA A 318
LEU A 315
THR A 317
 None
 1.07A 2roxB-3dafA:
undetectable		 2roxB-3dafA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3daf 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 GLY A 316
ASP A 319
SER A 320
 None
 0.58A 3brfA-3dafA:
undetectable		 3brfA-3dafA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA315_0
(UNCHARACTERIZED
PROTEIN)		 3daf 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 11 THR A 147
ILE A 171
PHE A 162
LYS A   1
ILE A   3
 None
 1.39A 3ijdA-3dafA:
0.0		 3ijdA-3dafA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 3daf 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 8 ILE A  96
THR A  45
ALA A  25
LEU A  39
THR A  40
 None
 1.47A 5og9A-3dafA:
undetectable		 5og9A-3dafA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3daf 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ILE A 119
VAL A  74
PRO A  71
 None
 0.58A 5uunA-3dafA:
undetectable		 5uunA-3dafA:
21.68