SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dah'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Burkholderia
pseudomallei) 		5 / 12 PHE A 302
ILE A 129
LEU A  73
VAL A   9
ALA A  19
 None
 1.04A 1epbA-3dahA:
undetectable		 1epbA-3dahA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Burkholderia
pseudomallei) 		4 / 7 PHE A  95
ALA A 117
PHE A 142
PHE A 141
 None
 1.28A 1lqtA-3dahA:
undetectable		 1lqtA-3dahA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Burkholderia
pseudomallei) 		4 / 7 PHE A  95
ALA A 117
PHE A 142
PHE A 141
 None
 1.29A 1lquA-3dahA:
undetectable		 1lquA-3dahA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Burkholderia
pseudomallei) 		4 / 7 GLY A 296
ILE A 154
THR A 274
LEU A 298
 None
 0.93A 2xrhA-3dahA:
undetectable		 2xrhA-3dahA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Burkholderia
pseudomallei) 		5 / 12 THR A 130
ILE A 128
ALA A  98
GLY A  96
THR A  62
 None
 1.00A 2y7hB-3dahA:
2.3		 2y7hB-3dahA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Burkholderia
pseudomallei) 		5 / 12 THR A 130
ILE A 128
ALA A  98
GLY A  96
THR A  62
 None
 1.00A 2y7hC-3dahA:
undetectable		 2y7hC-3dahA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Burkholderia
pseudomallei) 		5 / 12 VAL A 225
LEU A 271
GLY A 258
ALA A 259
LEU A 255
 PO4  A 320 ( 4.4A)
None
None
None
None
 1.07A 3rr3A-3dahA:
undetectable		 3rr3A-3dahA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Burkholderia
pseudomallei) 		5 / 12 VAL A 225
LEU A 271
GLY A 258
ALA A 259
LEU A 255
 PO4  A 320 ( 4.4A)
None
None
None
None
 1.07A 3rr3B-3dahA:
undetectable		 3rr3B-3dahA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Burkholderia
pseudomallei) 		5 / 12 LEU A  26
THR A 276
HIS A 252
VAL A   9
ILE A 129
 None
 1.15A 3sp9A-3dahA:
undetectable		 3sp9A-3dahA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Burkholderia
pseudomallei) 		5 / 11 CYH A 232
LEU A 231
GLU A 270
ALA A 248
VAL A 246
 None
 1.24A 4e0fA-3dahA:
undetectable		 4e0fA-3dahA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Burkholderia
pseudomallei) 		3 / 3 ASP A 101
ARG A 102
ASP A 136
 None
AMP  A 401 ( 4.7A)
None
 0.67A 4fp9A-3dahA:
undetectable		 4fp9A-3dahA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Burkholderia
pseudomallei) 		3 / 3 ASP A 101
ARG A 102
ASP A 136
 None
AMP  A 401 ( 4.7A)
None
 0.66A 4fp9F-3dahA:
undetectable		 4fp9F-3dahA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Burkholderia
pseudomallei) 		5 / 12 ILE A  88
ILE A  92
PRO A  93
LEU A  73
VAL A 125
 None
 0.88A 4kfjB-3dahA:
undetectable		 4kfjB-3dahA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Burkholderia
pseudomallei) 		4 / 7 VAL A 273
ILE A 289
ILE A 263
ALA A 259
 None
 0.77A 4lv9A-3dahA:
undetectable		 4lv9A-3dahA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Burkholderia
pseudomallei) 		4 / 7 VAL A 273
ILE A 289
ILE A 263
ALA A 259
 None
 0.79A 4lv9B-3dahA:
undetectable		 4lv9B-3dahA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Burkholderia
pseudomallei) 		3 / 3 GLU A 270
ALA A 248
PHE A 247
 None
 0.66A 4v1fA-3dahA:
undetectable		 4v1fA-3dahA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Burkholderia
pseudomallei) 		3 / 3 GLU A 270
ALA A 248
PHE A 247
 None
 0.66A 4v1fC-3dahA:
undetectable		 4v1fC-3dahA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Burkholderia
pseudomallei) 		4 / 7 ASN A 118
LYS A 114
TYR A  97
LEU A 133
 None
 1.06A 4yv5A-3dahA:
undetectable		 4yv5A-3dahA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Burkholderia
pseudomallei) 		5 / 12 VAL A 225
SER A 266
GLY A 258
ALA A 259
LEU A 255
 PO4  A 320 ( 4.4A)
None
None
None
None
 1.11A 5iktA-3dahA:
undetectable		 5iktA-3dahA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Burkholderia
pseudomallei) 		5 / 12 VAL A  22
VAL A  23
PHE A 302
ILE A  88
VAL A  56
 None
 1.17A 5n0sB-3dahA:
undetectable		 5n0sB-3dahA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Burkholderia
pseudomallei) 		5 / 12 ALA A 235
ALA A 234
GLN A 236
LEU A 268
ALA A 267
 None
 0.89A 5z12C-3dahA:
undetectable		 5z12C-3dahA:
15.79