SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dak'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
4 / 8 PHE A 290
MET A 267
PHE A 213
LEU A 220
None
1.18A 1ea1A-3dakA:
undetectable
1ea1A-3dakA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
6 / 10 ILE A  23
VAL A  31
ALA A  44
LEU A  94
LEU A 153
ASP A 164
ANP  A   1 (-4.2A)
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
None
None
ANP  A   1 (-3.8A)
0.81A 2y7jB-3dakA:
25.0
2y7jB-3dakA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
6 / 10 ILE A  23
VAL A  31
ALA A  44
LEU A  94
ASP A 102
LEU A 153
ANP  A   1 (-4.2A)
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
None
None
None
0.81A 2y7jC-3dakA:
24.9
2y7jC-3dakA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
6 / 10 VAL A  31
ALA A  44
LEU A  94
GLY A  98
ASP A 102
LEU A 153
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
None
None
None
None
0.90A 2y7jC-3dakA:
24.9
2y7jC-3dakA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
6 / 10 ILE A  23
VAL A  31
ALA A  44
LEU A  94
ASP A 102
LEU A 153
ANP  A   1 (-4.2A)
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
None
None
None
0.91A 2y7jD-3dakA:
24.5
2y7jD-3dakA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
4 / 7 LYS A  46
LEU A  90
LEU A  94
ILE A 162
ANP  A   1 (-2.8A)
None
None
None
0.91A 3gp0A-3dakA:
19.8
3gp0A-3dakA:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
7 / 12 VAL A  31
ALA A  44
LYS A  46
LEU A  90
MET A  92
LEU A  94
ASP A 102
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
ANP  A   1 (-2.8A)
None
None
None
None
0.81A 3ug2A-3dakA:
20.8
3ug2A-3dakA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
8 / 12 GLY A  24
VAL A  31
ALA A  44
LYS A  46
LEU A  90
ASP A 102
LEU A 153
ASP A 164
ANP  A   1 (-3.3A)
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
ANP  A   1 (-2.8A)
None
None
None
ANP  A   1 (-3.8A)
0.87A 4i22A-3dakA:
22.7
4i22A-3dakA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
8 / 12 GLY A  24
VAL A  31
ALA A  44
LYS A  46
LEU A  90
MET A  92
ASP A 102
ASP A 164
ANP  A   1 (-3.3A)
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
ANP  A   1 (-2.8A)
None
None
None
ANP  A   1 (-3.8A)
0.89A 4i22A-3dakA:
22.7
4i22A-3dakA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
7 / 12 VAL A  31
ALA A  44
ASP A 102
ASP A 146
LYS A 148
ASN A 151
LEU A 153
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
None
ANP  A   1 (-4.3A)
ANP  A   1 ( 4.8A)
ANP  A   1 ( 3.4A)
None
0.70A 4i41A-3dakA:
22.7
4i41A-3dakA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
7 / 12 GLY A  24
VAL A  31
ALA A  44
LYS A  46
LEU A  90
GLY A  98
LEU A 153
ANP  A   1 (-3.3A)
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
ANP  A   1 (-2.8A)
None
None
None
0.50A 4ifgA-3dakA:
23.9
4ifgA-3dakA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
7 / 11 GLY A  24
VAL A  31
ALA A  44
LYS A  46
ASN A 151
LEU A 153
ASP A 164
ANP  A   1 (-3.3A)
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
ANP  A   1 (-2.8A)
ANP  A   1 ( 3.4A)
None
ANP  A   1 (-3.8A)
0.95A 4o0sA-3dakA:
25.7
4o0sA-3dakA:
27.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
4 / 6 VAL A  31
ALA A  44
LYS A  46
LEU A 153
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
ANP  A   1 (-2.8A)
None
0.70A 4o0uA-3dakA:
6.9
4o0uA-3dakA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
6 / 9 ILE A  23
VAL A  31
ALA A  44
ASN A 151
LEU A 153
ASP A 164
ANP  A   1 (-4.2A)
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
ANP  A   1 ( 3.4A)
None
ANP  A   1 (-3.8A)
0.99A 4ogrI-3dakA:
21.3
4ogrI-3dakA:
27.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
7 / 12 ILE A  23
GLY A  24
VAL A  31
ALA A  44
MET A  92
LEU A  95
LEU A 153
ANP  A   1 (-4.2A)
ANP  A   1 (-3.3A)
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
None
ANP  A   1 (-4.1A)
None
0.76A 4qmzA-3dakA:
26.8
4qmzA-3dakA:
44.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
5 / 10 ILE A  23
ALA A  44
LYS A  46
LEU A  94
LEU A 153
ANP  A   1 (-4.2A)
ANP  A   1 ( 3.9A)
ANP  A   1 (-2.8A)
None
None
0.76A 4rz7A-3dakA:
6.4
4rz7A-3dakA:
18.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
6 / 12 VAL A  31
ALA A  44
LEU A 137
HIS A 144
ALA A 163
GLY A 166
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
None
None
MG  A 296 ( 3.9A)
None
0.71A 4v04A-3dakA:
21.3
4v04A-3dakA:
30.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
5 / 12 ALA A  44
LEU A 137
HIS A 144
ALA A 163
GLY A 166
ANP  A   1 ( 3.9A)
None
None
MG  A 296 ( 3.9A)
None
0.76A 4v04B-3dakA:
21.8
4v04B-3dakA:
30.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
3 / 3 ASP A 205
ARG A 279
PRO A 276
None
0.99A 4wanC-3dakA:
0.7
4wanC-3dakA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
4 / 5 LEU A 220
PHE A 264
ILE A 218
ILE A 268
None
1.06A 5dzk4-3dakA:
undetectable
5dzkg-3dakA:
undetectable
5dzkm-3dakA:
undetectable
5dzkn-3dakA:
undetectable
5dzk4-3dakA:
3.57
5dzkg-3dakA:
21.43
5dzkm-3dakA:
20.20
5dzkn-3dakA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
7 / 12 ILE A  23
GLY A  24
VAL A  31
ALA A  44
VAL A  76
LEU A 153
ALA A 163
ANP  A   1 (-4.2A)
ANP  A   1 (-3.3A)
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
None
None
MG  A 296 ( 3.9A)
0.73A 5l2iA-3dakA:
5.5
5l2iA-3dakA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
7 / 12 ILE A  23
GLY A  24
VAL A  31
ALA A  44
VAL A  76
LEU A 153
ALA A 163
ANP  A   1 (-4.2A)
ANP  A   1 (-3.3A)
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
None
None
MG  A 296 ( 3.9A)
0.93A 5l2tA-3dakA:
22.1
5l2tA-3dakA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
5 / 12 PHE A 264
ALA A 149
GLY A 214
ILE A 268
LEU A 257
None
1.08A 5ul4A-3dakA:
2.3
5ul4A-3dakA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
4 / 4 VAL A  76
LEU A  94
ASN A 151
ASP A 164
None
None
ANP  A   1 ( 3.4A)
ANP  A   1 (-3.8A)
1.19A 5vcyA-3dakA:
21.5
5vcyA-3dakA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
4 / 5 HIS A 144
MET A  67
ASN A  74
VAL A  76
None
1.41A 5xdhD-3dakA:
undetectable
5xdhD-3dakA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
8 / 12 GLY A  24
VAL A  31
ALA A  44
LYS A  46
MET A  67
LEU A  90
LEU A 153
ASP A 164
ANP  A   1 (-3.3A)
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
ANP  A   1 (-2.8A)
None
None
None
ANP  A   1 (-3.8A)
0.79A 5yu9A-3dakA:
22.7
5yu9A-3dakA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
9 / 12 GLY A  24
VAL A  31
ALA A  44
LYS A  46
MET A  67
LEU A  90
ASP A 102
LEU A 153
ASP A 164
ANP  A   1 (-3.3A)
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
ANP  A   1 (-2.8A)
None
None
None
None
ANP  A   1 (-3.8A)
0.98A 5yu9B-3dakA:
22.8
5yu9B-3dakA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
7 / 12 VAL A  31
ALA A  44
LYS A  46
MET A  67
LEU A  90
ASP A 102
ASP A 164
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
ANP  A   1 (-2.8A)
None
None
None
ANP  A   1 (-3.8A)
0.83A 5yu9C-3dakA:
22.4
5yu9C-3dakA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
6 / 12 VAL A  31
ALA A  44
MET A  67
LEU A  90
GLY A  98
ASP A 164
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
None
None
None
ANP  A   1 (-3.8A)
0.77A 5yu9C-3dakA:
22.4
5yu9C-3dakA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
6 / 12 VAL A  31
ALA A  44
LYS A  46
MET A  67
ASP A 102
ASP A 164
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
ANP  A   1 (-2.8A)
None
None
ANP  A   1 (-3.8A)
1.01A 5yu9D-3dakA:
22.7
5yu9D-3dakA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
6 / 12 VAL A  31
ALA A  44
LYS A  46
MET A  92
ASP A 102
ASP A 164
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
ANP  A   1 (-2.8A)
None
None
ANP  A   1 (-3.8A)
1.26A 5yu9D-3dakA:
22.7
5yu9D-3dakA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo
sapiens)
6 / 12 VAL A  31
ALA A  44
MET A  67
GLY A  98
LEU A 153
ASP A 164
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
None
None
None
ANP  A   1 (-3.8A)
0.84A 5yu9D-3dakA:
22.7
5yu9D-3dakA:
15.25