SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dan'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 3dan CYTOCHROME P450 74A2
(Parthenium
argentatum) 		4 / 7 THR A 288
GLY A 293
LEU A 299
TYR A 392
 None
 0.86A 1gtiB-3danA:
undetectable		 1gtiB-3danA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 3dan CYTOCHROME P450 74A2
(Parthenium
argentatum) 		4 / 7 THR A 288
GLY A 293
LEU A 299
TYR A 392
 None
 1.00A 1gtiE-3danA:
undetectable		 1gtiE-3danA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 3dan CYTOCHROME P450 74A2
(Parthenium
argentatum) 		3 / 3 LEU A 214
PRO A 215
LEU A 218
 None
 0.45A 1hrkA-3danA:
undetectable		 1hrkA-3danA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 3dan CYTOCHROME P450 74A2
(Parthenium
argentatum) 		3 / 3 GLY A 413
GLU A 417
ASN A 412
 None
None
HEM  A 600 (-4.4A)
 0.68A 1zq9A-3danA:
undetectable		 1zq9A-3danA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 3dan CYTOCHROME P450 74A2
(Parthenium
argentatum) 		5 / 12 ASN A 184
GLY A 191
PHE A 173
GLY A 177
VAL A 247
 None
 1.16A 2fqyA-3danA:
undetectable		 2fqyA-3danA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 3dan CYTOCHROME P450 74A2
(Parthenium
argentatum) 		3 / 3 LYS A  88
GLY A 413
PRO A 414
 HEM  A 600 (-3.1A)
None
None
 0.74A 2hreB-3danA:
undetectable		 2hreB-3danA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 3dan CYTOCHROME P450 74A2
(Parthenium
argentatum) 		4 / 4 LEU A 465
THR A 466
ILE A 292
HIS A 300
 None
 1.25A 2jfaB-3danA:
1.9		 2jfaB-3danA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 3dan CYTOCHROME P450 74A2
(Parthenium
argentatum) 		4 / 7 LEU A 303
ALA A 295
GLY A 293
PHE A 444
 None
 0.90A 2wq5A-3danA:
undetectable		 2wq5A-3danA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3dan CYTOCHROME P450 74A2
(Parthenium
argentatum) 		3 / 3 THR A  93
SER A 110
LYS A 424
 None
HEM  A 600 ( 3.9A)
HEM  A 600 (-2.7A)
 1.21A 3aocC-3danA:
undetectable		 3aocC-3danA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 3dan CYTOCHROME P450 74A2
(Parthenium
argentatum) 		5 / 12 TYR A 243
GLY A 279
ASN A 276
ALA A 179
PHE A 244
 None
None
HEM  A 600 ( 4.0A)
None
None
 1.17A 3vywC-3danA:
undetectable		 3vywC-3danA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3dan CYTOCHROME P450 74A2
(Parthenium
argentatum) 		3 / 3 LEU A 214
PRO A 215
LEU A 218
 None
 0.47A 3w1wB-3danA:
undetectable		 3w1wB-3danA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3dan CYTOCHROME P450 74A2
(Parthenium
argentatum) 		4 / 7 ASN A 287
GLU A 336
GLU A 341
ARG A 339
 None
 1.11A 4mi4B-3danA:
undetectable
4mi4C-3danA:
undetectable		 4mi4B-3danA:
19.41
4mi4C-3danA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3dan CYTOCHROME P450 74A2
(Parthenium
argentatum) 		4 / 8 ASN A 287
GLU A 336
GLU A 341
ARG A 339
 None
 1.10A 4mj8B-3danA:
undetectable
4mj8C-3danA:
undetectable		 4mj8B-3danA:
20.15
4mj8C-3danA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA601_1
(SERUM ALBUMIN)		 3dan CYTOCHROME P450 74A2
(Parthenium
argentatum) 		5 / 12 PHE A 439
LEU A 443
TYR A 447
VAL A 463
LEU A 465
 None
 1.47A 4po0A-3danA:
undetectable		 4po0A-3danA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3dan CYTOCHROME P450 74A2
(Parthenium
argentatum) 		4 / 7 ASN A 354
LYS A 368
LYS A 367
PHE A  52
 None
 0.94A 4yv5A-3danA:
undetectable		 4yv5A-3danA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 3dan CYTOCHROME P450 74A2
(Parthenium
argentatum) 		4 / 7 ILE A  69
LEU A  71
GLY A 349
LYS A 350
 None
 1.02A 4z69A-3danA:
2.4		 4z69A-3danA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3dan CYTOCHROME P450 74A2
(Parthenium
argentatum) 		4 / 6 TYR A 237
ASP A 263
HIS A 267
ILE A 269
 None
 1.08A 5ih0A-3danA:
undetectable		 5ih0A-3danA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3dan CYTOCHROME P450 74A2
(Parthenium
argentatum) 		4 / 8 THR A 196
CYH A 274
TRP A 201
LEU A 240
 None
 1.46A 5kxiA-3danA:
1.9
5kxiB-3danA:
undetectable		 5kxiA-3danA:
21.25
5kxiB-3danA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3dan CYTOCHROME P450 74A2
(Parthenium
argentatum) 		4 / 8 THR A 196
CYH A 274
TRP A 201
LEU A 240
 None
 1.41A 5kxiD-3danA:
1.6
5kxiE-3danA:
undetectable		 5kxiD-3danA:
21.25
5kxiE-3danA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3dan CYTOCHROME P450 74A2
(Parthenium
argentatum) 		5 / 12 ILE A  11
PHE A 355
LEU A  71
VAL A  51
ILE A 357
 None
 0.99A 5mueA-3danA:
undetectable		 5mueA-3danA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_1
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 3dan CYTOCHROME P450 74A2
(Parthenium
argentatum) 		5 / 12 GLY A 279
LEU A 102
TRP A 201
THR A  93
TYR A  96
 None
 1.21A 5nknA-3danA:
undetectable		 5nknA-3danA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3dan CYTOCHROME P450 74A2
(Parthenium
argentatum) 		4 / 5 MET A  97
TYR A 106
GLY A 105
GLY A 104
 None
 1.19A 5x7pA-3danA:
undetectable		 5x7pA-3danA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 3dan CYTOCHROME P450 74A2
(Parthenium
argentatum) 		5 / 12 HIS A 224
GLN A 219
LEU A 459
LEU A 203
ALA A 207
 None
 1.46A 5xprA-3danA:
1.6		 5xprA-3danA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 3dan CYTOCHROME P450 74A2
(Parthenium
argentatum) 		4 / 8 TYR A 335
VAL A 433
ILE A 324
GLU A 325
 None
 0.98A 6hzpA-3danA:
undetectable		 6hzpA-3danA:
22.88