SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3daq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 3daq DIHYDRODIPICOLINATE
SYNTHASE
(Staphylococcus
aureus) 		5 / 12 GLY A 189
VAL A 133
ILE A  76
GLY A   9
VAL A   8
 GOL  A 295 (-3.8A)
None
None
None
None
 1.09A 2avsB-3daqA:
undetectable		 2avsB-3daqA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 3daq DIHYDRODIPICOLINATE
SYNTHASE
(Staphylococcus
aureus) 		4 / 8 ILE A  61
ARG A 268
LEU A  53
GLU A  57
 None
 0.88A 2cdqA-3daqA:
undetectable		 2cdqA-3daqA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 3daq DIHYDRODIPICOLINATE
SYNTHASE
(Staphylococcus
aureus) 		5 / 12 GLY A 189
ASN A 211
GLY A 238
LEU A 241
LEU A 240
 GOL  A 295 (-3.8A)
None
None
None
None
 1.07A 2hw2A-3daqA:
undetectable		 2hw2A-3daqA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 3daq DIHYDRODIPICOLINATE
SYNTHASE
(Staphylococcus
aureus) 		5 / 11 LEU A 220
ILE A 237
PHE A 234
LEU A 241
ASP A 191
 None
 1.26A 2qeiA-3daqA:
undetectable		 2qeiA-3daqA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 3daq DIHYDRODIPICOLINATE
SYNTHASE
(Staphylococcus
aureus) 		4 / 8 GLY A  45
ILE A 253
ASN A 211
GLU A  49
 GOL  A 296 (-3.2A)
None
None
None
 0.90A 2x0pA-3daqA:
undetectable		 2x0pA-3daqA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3daq DIHYDRODIPICOLINATE
SYNTHASE
(Staphylococcus
aureus) 		3 / 3 TYR A 171
GLU A 146
THR A 106
 None
 1.02A 2y7hB-3daqA:
undetectable		 2y7hB-3daqA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3daq DIHYDRODIPICOLINATE
SYNTHASE
(Staphylococcus
aureus) 		5 / 12 ILE A  41
VAL A  43
ILE A 102
ALA A  40
VAL A  69
 None
 0.91A 3fpjA-3daqA:
undetectable		 3fpjA-3daqA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 3daq DIHYDRODIPICOLINATE
SYNTHASE
(Staphylococcus
aureus) 		3 / 3 ASP A 192
ASN A 167
SER A 245
 None
 0.98A 3lslA-3daqA:
undetectable
3lslD-3daqA:
undetectable		 3lslA-3daqA:
21.96
3lslD-3daqA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 3daq DIHYDRODIPICOLINATE
SYNTHASE
(Staphylococcus
aureus) 		4 / 7 ARG A 178
ILE A 179
LEU A 134
THR A 144
 None
 1.27A 3nxuA-3daqA:
undetectable		 3nxuA-3daqA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 3daq DIHYDRODIPICOLINATE
SYNTHASE
(Staphylococcus
aureus) 		5 / 12 ILE A 159
PHE A 121
VAL A 128
LEU A 104
ALA A  90
 None
 1.32A 3ozuA-3daqA:
2.1		 3ozuA-3daqA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3daq DIHYDRODIPICOLINATE
SYNTHASE
(Staphylococcus
aureus) 		5 / 11 VAL A  75
ALA A  40
PHE A 262
LEU A  26
VAL A  43
 None
 1.25A 4eilA-3daqA:
undetectable		 4eilA-3daqA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3daq DIHYDRODIPICOLINATE
SYNTHASE
(Staphylococcus
aureus) 		5 / 10 VAL A  75
ALA A  40
PHE A 262
LEU A  26
VAL A  43
 None
 1.27A 4eilB-3daqA:
undetectable		 4eilB-3daqA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3daq DIHYDRODIPICOLINATE
SYNTHASE
(Staphylococcus
aureus) 		5 / 11 VAL A  75
ALA A  40
PHE A 262
LEU A  26
VAL A  43
 None
 1.22A 4eilC-3daqA:
undetectable		 4eilC-3daqA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3daq DIHYDRODIPICOLINATE
SYNTHASE
(Staphylococcus
aureus) 		5 / 11 VAL A  75
ALA A  40
PHE A 262
LEU A  26
VAL A  43
 None
 1.25A 4eilE-3daqA:
undetectable		 4eilE-3daqA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 3daq DIHYDRODIPICOLINATE
SYNTHASE
(Staphylococcus
aureus) 		4 / 8 ASN A 193
VAL A 205
LEU A 241
TYR A 198
 None
 1.18A 4f5zA-3daqA:
undetectable		 4f5zA-3daqA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3daq DIHYDRODIPICOLINATE
SYNTHASE
(Staphylococcus
aureus) 		5 / 11 VAL A  75
ALA A  40
PHE A 262
LEU A  26
VAL A  43
 None
 1.26A 4kyaA-3daqA:
undetectable		 4kyaA-3daqA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3daq DIHYDRODIPICOLINATE
SYNTHASE
(Staphylococcus
aureus) 		5 / 12 VAL A  75
ALA A  40
PHE A 262
LEU A  26
VAL A  43
 None
 1.15A 4kyaB-3daqA:
undetectable		 4kyaB-3daqA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3daq DIHYDRODIPICOLINATE
SYNTHASE
(Staphylococcus
aureus) 		5 / 10 VAL A  75
ALA A  40
PHE A 262
LEU A  26
VAL A  43
 None
 1.25A 4kyaC-3daqA:
undetectable		 4kyaC-3daqA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3daq DIHYDRODIPICOLINATE
SYNTHASE
(Staphylococcus
aureus) 		5 / 12 VAL A  75
ALA A  40
PHE A 262
LEU A  26
VAL A  43
 None
 1.17A 4kyaD-3daqA:
undetectable		 4kyaD-3daqA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3daq DIHYDRODIPICOLINATE
SYNTHASE
(Staphylococcus
aureus) 		5 / 11 VAL A  75
ALA A  40
PHE A 262
LEU A  26
VAL A  43
 None
 1.25A 4kyaE-3daqA:
undetectable		 4kyaE-3daqA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3daq DIHYDRODIPICOLINATE
SYNTHASE
(Staphylococcus
aureus) 		5 / 12 VAL A  75
ALA A  40
PHE A 262
LEU A  26
VAL A  43
 None
 1.18A 4kyaF-3daqA:
undetectable		 4kyaF-3daqA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3daq DIHYDRODIPICOLINATE
SYNTHASE
(Staphylococcus
aureus) 		5 / 11 VAL A  75
ALA A  40
PHE A 262
LEU A  26
VAL A  43
 None
 1.27A 4kyaG-3daqA:
undetectable		 4kyaG-3daqA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3daq DIHYDRODIPICOLINATE
SYNTHASE
(Staphylococcus
aureus) 		5 / 12 VAL A  75
ALA A  40
PHE A 262
LEU A  26
VAL A  43
 None
 1.16A 4kyaH-3daqA:
undetectable		 4kyaH-3daqA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 3daq DIHYDRODIPICOLINATE
SYNTHASE
(Staphylococcus
aureus) 		5 / 12 LEU A 282
ARG A 283
ALA A 291
ILE A 209
LEU A 260
 None
 1.32A 4l9qA-3daqA:
undetectable		 4l9qA-3daqA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3daq DIHYDRODIPICOLINATE
SYNTHASE
(Staphylococcus
aureus) 		4 / 4 GLY A  98
LEU A   4
PHE A   5
ILE A  76
 None
 0.79A 4xv2A-3daqA:
undetectable		 4xv2A-3daqA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3daq DIHYDRODIPICOLINATE
SYNTHASE
(Staphylococcus
aureus) 		3 / 3 ILE A  41
VAL A  10
PRO A 214
 None
 0.72A 5uunA-3daqA:
undetectable		 5uunA-3daqA:
21.66