SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dbo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 3dbo UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 LEU B 139
PHE B 136
ALA B 137
LEU B 104
 None
 0.82A 1ukbA-3dboB:
undetectable		 1ukbA-3dboB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 3dbo UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 GLN A  69
ARG A  64
LEU B  39
VAL B  29
 None
 1.02A 2bdmA-3dboA:
undetectable		 2bdmA-3dboA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3dbo UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 ILE B  70
ASP A  77
LEU A  74
GLY A  73
 None
 0.90A 2qqdB-3dboB:
undetectable
2qqdC-3dboB:
undetectable		 2qqdB-3dboB:
20.81
2qqdC-3dboB:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3dbo UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 5 LEU B  58
GLN A  69
THR B  77
THR B  51
 None
None
None
NA  B 301 (-2.8A)
 1.28A 2zj0B-3dboB:
undetectable		 2zj0B-3dboB:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 3dbo UNCHARACTERIZED
PROTEIN
UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		3 / 3 ASN A  76
ASP B 133
GLN B 132
 None
 0.73A 3eeyC-3dboA:
undetectable		 3eeyC-3dboA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 3dbo UNCHARACTERIZED
PROTEIN
UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		3 / 3 ASN A  76
ASP B 133
GLN B 132
 None
 0.74A 3eeyD-3dboA:
undetectable		 3eeyD-3dboA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 3dbo UNCHARACTERIZED
PROTEIN
UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		3 / 3 ASN A  76
ASP B 133
GLN B 132
 None
 0.73A 3eeyE-3dboA:
undetectable		 3eeyE-3dboA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3dbo UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 THR B  27
GLU B  57
THR B  54
LEU A  74
 None
None
NA  B 301 (-3.5A)
None
 1.02A 4pgfA-3dboB:
undetectable		 4pgfA-3dboB:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 3dbo UNCHARACTERIZED
PROTEIN
UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		5 / 11 SER B  80
LEU B  75
ASP A  71
GLN B  73
ALA B  72
 None
 1.29A 4uuuB-3dboB:
undetectable		 4uuuB-3dboB:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 3dbo UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 ILE B  70
ASP A  71
GLY B  61
LEU A  81
 None
 1.06A 5hwaA-3dboB:
undetectable		 5hwaA-3dboB:
20.80