SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dc6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 3dc6 SUPEROXIDE DISMUTASE
[MN] 1
(Caenorhabditis
elegans) 		5 / 12 ILE A  18
VAL A 188
LEU A  81
LEU A 110
ILE A 157
 None
 1.30A 1kqwA-3dc6A:
undetectable		 1kqwA-3dc6A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 3dc6 SUPEROXIDE DISMUTASE
[MN] 1
(Caenorhabditis
elegans) 		6 / 12 SER A 120
GLN A 142
LEU A  81
HIS A  74
ILE A  22
ALA A 163
 None
MN  A 198 ( 4.8A)
None
MN  A 198 (-3.3A)
None
MN  A 198 ( 4.9A)
 1.17A 2bxcA-3dc6A:
undetectable		 2bxcA-3dc6A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 3dc6 SUPEROXIDE DISMUTASE
[MN] 1
(Caenorhabditis
elegans) 		4 / 6 PHE A 155
TRP A 180
GLY A  85
GLY A  86
 None
 0.83A 2qr2A-3dc6A:
undetectable
2qr2B-3dc6A:
undetectable		 2qr2A-3dc6A:
22.35
2qr2B-3dc6A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 3dc6 SUPEROXIDE DISMUTASE
[MN] 1
(Caenorhabditis
elegans) 		4 / 5 TRP A 180
GLY A  85
GLY A  86
PHE A 155
 None
 0.91A 2qr2A-3dc6A:
undetectable
2qr2B-3dc6A:
undetectable		 2qr2A-3dc6A:
22.35
2qr2B-3dc6A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WMZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3dc6 SUPEROXIDE DISMUTASE
[MN] 1
(Caenorhabditis
elegans) 		5 / 9 TYR A 164
ILE A 179
TYR A 175
GLY A 123
THR A 138
 None
 1.45A 4wmzA-3dc6A:
0.5		 4wmzA-3dc6A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3dc6 SUPEROXIDE DISMUTASE
[MN] 1
(Caenorhabditis
elegans) 		5 / 8 TYR A 164
ILE A 179
TYR A 175
GLY A 123
THR A 138
 None
 1.46A 5esfA-3dc6A:
0.2		 5esfA-3dc6A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 3dc6 SUPEROXIDE DISMUTASE
[MN] 1
(Caenorhabditis
elegans) 		4 / 8 ASN A  73
PHE A  66
HIS A   2
THR A 149
 None
None
SO4  A 200 (-4.0A)
None
 1.32A 5hqaA-3dc6A:
undetectable		 5hqaA-3dc6A:
14.97