SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dc8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 9 ARG A 290
GLY A 258
ALA A 218
THR A 237
ILE A 234
 None
 1.30A 1c9sA-3dc8A:
undetectable
1c9sB-3dc8A:
undetectable		 1c9sA-3dc8A:
10.52
1c9sB-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 10 ARG A 290
GLY A 258
ALA A 218
THR A 237
ILE A 234
 None
 1.31A 1c9sB-3dc8A:
undetectable
1c9sC-3dc8A:
undetectable		 1c9sB-3dc8A:
10.52
1c9sC-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 10 ARG A 290
GLY A 258
HIS A 243
ALA A 218
ILE A 234
 None
 1.28A 1c9sB-3dc8A:
undetectable
1c9sC-3dc8A:
undetectable		 1c9sB-3dc8A:
10.52
1c9sC-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 10 ARG A 290
GLY A 258
ALA A 218
THR A 237
ILE A 234
 None
 1.31A 1c9sG-3dc8A:
undetectable
1c9sH-3dc8A:
undetectable		 1c9sG-3dc8A:
10.52
1c9sH-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 10 ARG A 290
GLY A 258
HIS A 243
ALA A 218
ILE A 234
 None
 1.29A 1c9sG-3dc8A:
undetectable
1c9sH-3dc8A:
undetectable		 1c9sG-3dc8A:
10.52
1c9sH-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 12 ALA A  79
ILE A 369
LEU A 373
ARG A 452
THR A  76
 None
 1.32A 1d1gA-3dc8A:
undetectable		 1d1gA-3dc8A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		4 / 5 HIS A  56
HIS A 180
HIS A 236
ASP A 313
 ZN  A 502 (-3.3A)
ZN  A 501 (-3.1A)
ZN  A 501 (-3.4A)
ZN  A 502 (-2.7A)
 0.45A 1e9yB-3dc8A:
21.2		 1e9yB-3dc8A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 6 HIS A  56
HIS A  58
HIS A 180
HIS A 236
ASP A 313
 ZN  A 502 (-3.3A)
ZN  A 502 (-3.3A)
ZN  A 501 (-3.1A)
ZN  A 501 (-3.4A)
ZN  A 502 (-2.7A)
 0.57A 1fweC-3dc8A:
22.0		 1fweC-3dc8A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 10 ARG A 290
GLY A 258
ALA A 218
THR A 237
ILE A 234
 None
 1.31A 1gtfC-3dc8A:
undetectable
1gtfD-3dc8A:
undetectable		 1gtfC-3dc8A:
10.52
1gtfD-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 10 ARG A 290
GLY A 258
HIS A 243
ALA A 218
ILE A 234
 None
 1.31A 1gtfC-3dc8A:
undetectable
1gtfD-3dc8A:
undetectable		 1gtfC-3dc8A:
10.52
1gtfD-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 9 ARG A 290
GLY A 258
ALA A 218
THR A 237
ILE A 234
 None
 1.31A 1gtfF-3dc8A:
undetectable
1gtfG-3dc8A:
undetectable		 1gtfF-3dc8A:
10.52
1gtfG-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 10 ARG A 290
GLY A 258
ALA A 218
THR A 237
ILE A 234
 None
 1.30A 1gtfG-3dc8A:
undetectable
1gtfH-3dc8A:
undetectable		 1gtfG-3dc8A:
10.52
1gtfH-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 10 ARG A 290
GLY A 258
HIS A 243
ALA A 218
ILE A 234
 None
 1.28A 1gtfG-3dc8A:
undetectable
1gtfH-3dc8A:
undetectable		 1gtfG-3dc8A:
10.52
1gtfH-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 10 ARG A 290
GLY A 258
ALA A 218
THR A 237
ILE A 234
 None
 1.32A 1gtfH-3dc8A:
undetectable
1gtfI-3dc8A:
undetectable		 1gtfH-3dc8A:
10.52
1gtfI-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 10 ARG A 290
GLY A 258
HIS A 243
ALA A 218
ILE A 234
 None
 1.28A 1gtfH-3dc8A:
undetectable
1gtfI-3dc8A:
undetectable		 1gtfH-3dc8A:
10.52
1gtfI-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		4 / 8 GLU A 214
ILE A 246
PRO A 260
LEU A 307
 None
 0.77A 1hmyA-3dc8A:
undetectable		 1hmyA-3dc8A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		3 / 3 ARG A 452
THR A  57
VAL A  88
 None
 1.00A 1hxbA-3dc8A:
undetectable		 1hxbA-3dc8A:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 11 ALA A  79
ILE A 369
LEU A 373
ARG A 452
THR A  76
 None
 1.30A 1jomA-3dc8A:
undetectable		 1jomA-3dc8A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 222
GLY A 258
VAL A 256
ALA A 311
HIS A 236
 None
None
None
None
ZN  A 501 (-3.4A)
 1.40A 1nbhA-3dc8A:
undetectable		 1nbhA-3dc8A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 222
GLY A 258
VAL A 256
ALA A 311
HIS A 236
 None
None
None
None
ZN  A 501 (-3.4A)
 1.39A 1nbhD-3dc8A:
undetectable		 1nbhD-3dc8A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 12 GLU A 259
HIS A 236
HIS A 205
HIS A 180
TYR A 152
 None
ZN  A 501 (-3.4A)
None
ZN  A 501 (-3.1A)
None
 1.44A 1o86A-3dc8A:
undetectable		 1o86A-3dc8A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 12 GLU A 259
HIS A 236
PHE A  63
HIS A 180
TYR A 152
 None
ZN  A 501 (-3.4A)
None
ZN  A 501 (-3.1A)
None
 1.32A 1o86A-3dc8A:
undetectable		 1o86A-3dc8A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_M_TRPM81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 11 GLY A 258
HIS A 243
ALA A 218
ILE A 234
ARG A 290
 None
 1.33A 1utdM-3dc8A:
undetectable
1utdN-3dc8A:
undetectable		 1utdM-3dc8A:
10.52
1utdN-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		6 / 12 GLY A  32
ALA A  19
ASP A  20
VAL A  48
ILE A   5
ILE A  10
 None
 1.35A 2avvB-3dc8A:
undetectable		 2avvB-3dc8A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		6 / 12 GLY A  32
ALA A  19
ASP A  20
VAL A  48
ILE A   5
ILE A  10
 None
 1.33A 2bpxB-3dc8A:
undetectable		 2bpxB-3dc8A:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 12 HIS A 236
GLN A 263
HIS A 205
HIS A 180
TYR A 152
 ZN  A 501 (-3.4A)
None
None
ZN  A 501 (-3.1A)
None
 1.33A 2c6nA-3dc8A:
undetectable		 2c6nA-3dc8A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 11 ASP A 313
HIS A  56
GLU A 182
HIS A 236
SER A 286
 ZN  A 502 (-2.7A)
ZN  A 502 (-3.3A)
None
ZN  A 501 (-3.4A)
None
 1.25A 2q0jB-3dc8A:
undetectable		 2q0jB-3dc8A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		3 / 3 ARG A 452
THR A  57
VAL A  88
 None
 0.86A 2q64A-3dc8A:
undetectable		 2q64A-3dc8A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		3 / 3 ARG A 452
THR A  57
VAL A  88
 None
 1.00A 2qakA-3dc8A:
undetectable		 2qakA-3dc8A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA504_0
(CHORISMATE SYNTHASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		4 / 5 SER A 306
HIS A 243
LEU A 302
SER A 304
 None
 1.22A 2qhfA-3dc8A:
0.0		 2qhfA-3dc8A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 12 GLN A 406
ALA A 403
ALA A 316
PHE A 289
HIS A 279
 None
 1.23A 3b0wA-3dc8A:
undetectable		 3b0wA-3dc8A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 12 GLN A 406
ALA A 403
ALA A 316
PHE A 289
HIS A 279
 None
 1.19A 3b0wB-3dc8A:
undetectable		 3b0wB-3dc8A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 11 VAL A 235
LEU A 178
ILE A 369
PRO A  55
THR A  57
 KCX  A 147 ( 4.9A)
KCX  A 147 ( 4.5A)
None
None
None
 1.37A 3bjwE-3dc8A:
undetectable		 3bjwE-3dc8A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		4 / 4 THR A 405
VAL A 440
GLY A  82
THR A  84
 None
 0.79A 3cflA-3dc8A:
undetectable		 3cflA-3dc8A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 10 ILE A  10
ILE A  31
GLY A 385
TYR A 376
LEU A 390
 None
 1.26A 3elzC-3dc8A:
undetectable		 3elzC-3dc8A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A  41
VAL A  21
ILE A 382
GLY A  51
ILE A   5
 None
 0.87A 3em6B-3dc8A:
undetectable		 3em6B-3dc8A:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		4 / 4 GLY A 438
VAL A 440
GLY A  83
THR A  84
 None
 0.77A 3ib2A-3dc8A:
undetectable		 3ib2A-3dc8A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_1
(PROTEASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		6 / 12 GLY A  32
ALA A  19
VAL A  48
ILE A   5
VAL A  29
ILE A  10
 None
 1.36A 3nu5A-3dc8A:
undetectable		 3nu5A-3dc8A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_1
(PROTEASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A  41
VAL A  21
ILE A 382
GLY A  51
ILE A   5
 None
 0.86A 3nu5A-3dc8A:
undetectable		 3nu5A-3dc8A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		3 / 3 SER A 306
GLY A 305
GLN A 308
 None
 0.60A 3v4tH-3dc8A:
0.1		 3v4tH-3dc8A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		4 / 7 LEU A 261
ASP A 313
GLU A 182
HIS A 180
 None
ZN  A 502 (-2.7A)
None
ZN  A 501 (-3.1A)
 1.26A 4aq7A-3dc8A:
undetectable		 4aq7A-3dc8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 12 SER A 366
PRO A  50
GLY A  51
GLY A  52
VAL A 351
 None
 1.14A 4b17A-3dc8A:
undetectable		 4b17A-3dc8A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A  41
VAL A  21
ILE A 382
GLY A  51
ILE A   5
 None
 0.78A 4dqbA-3dc8A:
undetectable		 4dqbA-3dc8A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A  41
VAL A  21
ILE A 382
GLY A  51
ILE A   5
 None
 0.81A 4dqfA-3dc8A:
undetectable		 4dqfA-3dc8A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 8 GLY A 385
ALA A 386
ASP A 387
ASP A 389
THR A  12
 None
 1.06A 4eyrB-3dc8A:
undetectable		 4eyrB-3dc8A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		4 / 5 HIS A  56
HIS A 180
HIS A 236
ASP A 313
 ZN  A 502 (-3.3A)
ZN  A 501 (-3.1A)
ZN  A 501 (-3.4A)
ZN  A 502 (-2.7A)
 0.43A 4h9mA-3dc8A:
23.2		 4h9mA-3dc8A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		6 / 12 GLY A  32
ALA A  19
ASP A  20
VAL A  48
ILE A   5
ILE A  10
 None
 1.32A 4jecA-3dc8A:
undetectable		 4jecA-3dc8A:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		3 / 3 HIS A 205
TRP A 277
SER A 286
 None
 1.16A 4lrhD-3dc8A:
undetectable		 4lrhD-3dc8A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_1
(PROTEASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 11 LEU A  41
VAL A  21
ILE A 382
THR A   3
ILE A   5
 None
 0.95A 4njtA-3dc8A:
undetectable		 4njtA-3dc8A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_1
(PROTEASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 11 LEU A  41
VAL A  21
ILE A 382
GLY A  51
ILE A   5
 None
 0.95A 4njtC-3dc8A:
undetectable		 4njtC-3dc8A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A  32
VAL A  48
ILE A   5
THR A  12
ILE A  10
 None
 0.88A 4njvD-3dc8A:
undetectable		 4njvD-3dc8A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 12 MET A 163
VAL A 158
MET A 223
ILE A 222
VAL A 232
 None
 1.26A 4okwA-3dc8A:
undetectable		 4okwA-3dc8A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A 265
VAL A 310
PRO A 260
THR A 237
GLU A 214
 None
 1.17A 4q15B-3dc8A:
undetectable		 4q15B-3dc8A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 11 LEU A  41
VAL A  21
ILE A 382
GLY A  51
ILE A   5
 None
 0.82A 4rvjA-3dc8A:
undetectable		 4rvjA-3dc8A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 11 LEU A  41
VAL A  21
ILE A 382
GLY A  51
ILE A   5
 None
 0.83A 4rvjC-3dc8A:
undetectable		 4rvjC-3dc8A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 6 HIS A  56
HIS A  58
HIS A 180
HIS A 236
ASP A 313
 ZN  A 502 (-3.3A)
ZN  A 502 (-3.3A)
ZN  A 501 (-3.1A)
ZN  A 501 (-3.4A)
ZN  A 502 (-2.7A)
 0.45A 4ubpC-3dc8A:
22.2		 4ubpC-3dc8A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 11 ALA A 409
GLU A 340
LEU A 339
ASN A 114
LEU A  59
 None
 1.17A 4wg0G-3dc8A:
undetectable
4wg0H-3dc8A:
undetectable
4wg0I-3dc8A:
undetectable		 4wg0G-3dc8A:
3.61
4wg0H-3dc8A:
3.61
4wg0I-3dc8A:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 12 HIS A 236
HIS A  56
PHE A  90
LEU A 156
TYR A 152
 ZN  A 501 (-3.4A)
ZN  A 502 (-3.3A)
KCX  A 147 ( 3.8A)
None
None
 1.39A 5eenB-3dc8A:
undetectable		 5eenB-3dc8A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		6 / 10 ARG A 290
GLY A 258
HIS A 243
ALA A 218
THR A 237
ILE A 234
 None
 1.46A 5eeuD-3dc8A:
undetectable
5eeuE-3dc8A:
undetectable		 5eeuD-3dc8A:
10.52
5eeuE-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 10 ARG A 290
GLY A 258
ALA A 218
THR A 237
ILE A 234
 None
 1.31A 5eeuH-3dc8A:
undetectable
5eeuI-3dc8A:
undetectable		 5eeuH-3dc8A:
10.52
5eeuI-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 10 ARG A 290
GLY A 258
HIS A 243
ALA A 218
ILE A 234
 None
 1.29A 5eeuH-3dc8A:
undetectable
5eeuI-3dc8A:
undetectable		 5eeuH-3dc8A:
10.52
5eeuI-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 10 ARG A 290
GLY A 258
ALA A 218
THR A 237
ILE A 234
 None
 1.32A 5eeuJ-3dc8A:
undetectable
5eeuK-3dc8A:
undetectable		 5eeuJ-3dc8A:
10.52
5eeuK-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 10 ARG A 290
GLY A 258
HIS A 243
ALA A 218
ILE A 234
 None
 1.30A 5eeuJ-3dc8A:
undetectable
5eeuK-3dc8A:
undetectable		 5eeuJ-3dc8A:
10.52
5eeuK-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		6 / 10 ARG A 290
GLY A 258
HIS A 243
ALA A 218
THR A 237
ILE A 234
 None
 1.46A 5eevD-3dc8A:
undetectable
5eevE-3dc8A:
undetectable		 5eevD-3dc8A:
10.52
5eevE-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 10 ARG A 290
GLY A 258
ALA A 218
THR A 237
ILE A 234
 None
 1.32A 5eevJ-3dc8A:
undetectable
5eevK-3dc8A:
undetectable		 5eevJ-3dc8A:
10.52
5eevK-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 10 ARG A 290
GLY A 258
HIS A 243
ALA A 218
ILE A 234
 None
 1.30A 5eevJ-3dc8A:
undetectable
5eevK-3dc8A:
undetectable		 5eevJ-3dc8A:
10.52
5eevK-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		6 / 10 ARG A 290
GLY A 258
HIS A 243
ALA A 218
THR A 237
ILE A 234
 None
 1.46A 5eewD-3dc8A:
undetectable
5eewE-3dc8A:
undetectable		 5eewD-3dc8A:
10.52
5eewE-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 10 ARG A 290
GLY A 258
ALA A 218
THR A 237
ILE A 234
 None
 1.31A 5eewH-3dc8A:
undetectable
5eewI-3dc8A:
undetectable		 5eewH-3dc8A:
10.52
5eewI-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 10 ARG A 290
GLY A 258
HIS A 243
ALA A 218
ILE A 234
 None
 1.29A 5eewH-3dc8A:
undetectable
5eewI-3dc8A:
undetectable		 5eewH-3dc8A:
10.52
5eewI-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 10 ARG A 290
GLY A 258
ALA A 218
THR A 237
ILE A 234
 None
 1.32A 5eewJ-3dc8A:
undetectable
5eewK-3dc8A:
undetectable		 5eewJ-3dc8A:
10.52
5eewK-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 10 ARG A 290
GLY A 258
HIS A 243
ALA A 218
ILE A 234
 None
 1.30A 5eewJ-3dc8A:
undetectable
5eewK-3dc8A:
undetectable		 5eewJ-3dc8A:
10.52
5eewK-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		6 / 10 ARG A 290
GLY A 258
HIS A 243
ALA A 218
THR A 237
ILE A 234
 None
 1.46A 5eexD-3dc8A:
undetectable
5eexE-3dc8A:
undetectable		 5eexD-3dc8A:
10.52
5eexE-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 10 ARG A 290
GLY A 258
ALA A 218
THR A 237
ILE A 234
 None
 1.31A 5eexH-3dc8A:
undetectable
5eexI-3dc8A:
undetectable		 5eexH-3dc8A:
10.52
5eexI-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 10 ARG A 290
GLY A 258
HIS A 243
ALA A 218
ILE A 234
 None
 1.29A 5eexH-3dc8A:
undetectable
5eexI-3dc8A:
undetectable		 5eexH-3dc8A:
10.52
5eexI-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 11 ARG A 290
GLY A 258
ALA A 218
THR A 237
ILE A 234
 None
 1.30A 5eexI-3dc8A:
undetectable
5eexJ-3dc8A:
undetectable		 5eexI-3dc8A:
10.52
5eexJ-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 11 ARG A 290
GLY A 258
HIS A 243
ALA A 218
ILE A 234
 None
 1.28A 5eexI-3dc8A:
undetectable
5eexJ-3dc8A:
undetectable		 5eexI-3dc8A:
10.52
5eexJ-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 10 ARG A 290
GLY A 258
ALA A 218
THR A 237
ILE A 234
 None
 1.32A 5eexJ-3dc8A:
undetectable
5eexK-3dc8A:
undetectable		 5eexJ-3dc8A:
10.52
5eexK-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 10 ARG A 290
GLY A 258
HIS A 243
ALA A 218
ILE A 234
 None
 1.30A 5eexJ-3dc8A:
undetectable
5eexK-3dc8A:
undetectable		 5eexJ-3dc8A:
10.52
5eexK-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		6 / 10 ARG A 290
GLY A 258
HIS A 243
ALA A 218
THR A 237
ILE A 234
 None
 1.46A 5eeyD-3dc8A:
undetectable
5eeyE-3dc8A:
undetectable		 5eeyD-3dc8A:
10.52
5eeyE-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 11 ARG A 290
GLY A 258
ALA A 218
THR A 237
ILE A 234
 None
 1.30A 5eeyI-3dc8A:
undetectable
5eeyJ-3dc8A:
undetectable		 5eeyI-3dc8A:
10.52
5eeyJ-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 11 ARG A 290
GLY A 258
HIS A 243
ALA A 218
ILE A 234
 None
 1.28A 5eeyI-3dc8A:
undetectable
5eeyJ-3dc8A:
undetectable		 5eeyI-3dc8A:
10.52
5eeyJ-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 10 ARG A 290
GLY A 258
ALA A 218
THR A 237
ILE A 234
 None
 1.32A 5eeyJ-3dc8A:
undetectable
5eeyK-3dc8A:
undetectable		 5eeyJ-3dc8A:
10.52
5eeyK-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 10 ARG A 290
GLY A 258
HIS A 243
ALA A 218
ILE A 234
 None
 1.30A 5eeyJ-3dc8A:
undetectable
5eeyK-3dc8A:
undetectable		 5eeyJ-3dc8A:
10.52
5eeyK-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		6 / 10 ARG A 290
GLY A 258
HIS A 243
ALA A 218
THR A 237
ILE A 234
 None
 1.46A 5eezD-3dc8A:
undetectable
5eezE-3dc8A:
undetectable		 5eezD-3dc8A:
10.52
5eezE-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 11 ARG A 290
GLY A 258
ALA A 218
THR A 237
ILE A 234
 None
 1.31A 5eezI-3dc8A:
undetectable
5eezJ-3dc8A:
undetectable		 5eezI-3dc8A:
10.52
5eezJ-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 11 ARG A 290
GLY A 258
HIS A 243
ALA A 218
ILE A 234
 None
 1.28A 5eezI-3dc8A:
undetectable
5eezJ-3dc8A:
undetectable		 5eezI-3dc8A:
10.52
5eezJ-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		6 / 10 ARG A 290
GLY A 258
HIS A 243
ALA A 218
THR A 237
ILE A 234
 None
 1.46A 5ef0D-3dc8A:
undetectable
5ef0E-3dc8A:
undetectable		 5ef0D-3dc8A:
10.52
5ef0E-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 11 ARG A 290
GLY A 258
ALA A 218
THR A 237
ILE A 234
 None
 1.30A 5ef0I-3dc8A:
undetectable
5ef0J-3dc8A:
undetectable		 5ef0I-3dc8A:
10.52
5ef0J-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 11 ARG A 290
GLY A 258
HIS A 243
ALA A 218
ILE A 234
 None
 1.28A 5ef0I-3dc8A:
undetectable
5ef0J-3dc8A:
undetectable		 5ef0I-3dc8A:
10.52
5ef0J-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		6 / 10 ARG A 290
GLY A 258
HIS A 243
ALA A 218
THR A 237
ILE A 234
 None
 1.46A 5ef1D-3dc8A:
undetectable
5ef1E-3dc8A:
undetectable		 5ef1D-3dc8A:
10.52
5ef1E-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 11 ARG A 290
GLY A 258
ALA A 218
THR A 237
ILE A 234
 None
 1.30A 5ef1I-3dc8A:
undetectable
5ef1J-3dc8A:
undetectable		 5ef1I-3dc8A:
10.52
5ef1J-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 11 ARG A 290
GLY A 258
HIS A 243
ALA A 218
ILE A 234
 None
 1.28A 5ef1I-3dc8A:
undetectable
5ef1J-3dc8A:
undetectable		 5ef1I-3dc8A:
10.52
5ef1J-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		6 / 10 ARG A 290
GLY A 258
HIS A 243
ALA A 218
THR A 237
ILE A 234
 None
 1.46A 5ef2D-3dc8A:
undetectable
5ef2E-3dc8A:
undetectable		 5ef2D-3dc8A:
10.52
5ef2E-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 11 ARG A 290
GLY A 258
ALA A 218
THR A 237
ILE A 234
 None
 1.30A 5ef2I-3dc8A:
undetectable
5ef2J-3dc8A:
undetectable		 5ef2I-3dc8A:
10.52
5ef2J-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 11 ARG A 290
GLY A 258
HIS A 243
ALA A 218
ILE A 234
 None
 1.28A 5ef2I-3dc8A:
undetectable
5ef2J-3dc8A:
undetectable		 5ef2I-3dc8A:
10.52
5ef2J-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		6 / 10 ARG A 290
GLY A 258
HIS A 243
ALA A 218
THR A 237
ILE A 234
 None
 1.46A 5ef3D-3dc8A:
undetectable
5ef3E-3dc8A:
undetectable		 5ef3D-3dc8A:
10.52
5ef3E-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 11 ARG A 290
GLY A 258
ALA A 218
THR A 237
ILE A 234
 None
 1.30A 5ef3I-3dc8A:
undetectable
5ef3J-3dc8A:
undetectable		 5ef3I-3dc8A:
10.52
5ef3J-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 11 ARG A 290
GLY A 258
HIS A 243
ALA A 218
ILE A 234
 None
 1.28A 5ef3I-3dc8A:
undetectable
5ef3J-3dc8A:
undetectable		 5ef3I-3dc8A:
10.52
5ef3J-3dc8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 12 HIS A 236
HIS A  56
PHE A  90
LEU A 156
TYR A 152
 ZN  A 501 (-3.4A)
ZN  A 502 (-3.3A)
KCX  A 147 ( 3.8A)
None
None
 1.45A 5ef8B-3dc8A:
undetectable		 5ef8B-3dc8A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 410
GLY A 338
THR A 312
HIS A 180
PHE A  63
 None
None
None
ZN  A 501 (-3.1A)
None
 1.25A 5eslA-3dc8A:
undetectable		 5eslA-3dc8A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		4 / 8 ARG A 250
VAL A 256
GLY A 301
GLN A 308
 None
 0.89A 5sxqA-3dc8A:
undetectable		 5sxqA-3dc8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		4 / 8 ARG A 250
VAL A 256
GLY A 301
GLN A 308
 None
 0.86A 5sxtA-3dc8A:
undetectable		 5sxtA-3dc8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		4 / 8 ARG A 250
VAL A 256
GLY A 301
GLN A 308
 None
 0.86A 5sxtB-3dc8A:
undetectable		 5sxtB-3dc8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		4 / 8 ARG A 250
VAL A 256
GLY A 301
GLN A 308
 None
 0.80A 5syjB-3dc8A:
undetectable		 5syjB-3dc8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		3 / 3 GLY A 305
THR A 312
PRO A 260
 None
 0.65A 5v5zA-3dc8A:
undetectable		 5v5zA-3dc8A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A 265
VAL A 310
PRO A 260
THR A 237
GLU A 214
 None
 1.28A 5xipC-3dc8A:
undetectable		 5xipC-3dc8A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A 265
VAL A 310
PRO A 260
THR A 237
GLU A 214
 None
 1.31A 5xipD-3dc8A:
undetectable		 5xipD-3dc8A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		3 / 3 TRP A 126
ILE A 123
GLU A 133
 None
KCX  A 147 ( 4.5A)
None
 0.87A 6hcxA-3dc8A:
undetectable		 6hcxA-3dc8A:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3dc8 DIHYDROPYRIMIDINASE
(Sinorhizobium
meliloti) 		4 / 6 ASP A  89
GLU A  60
ASP A  71
GLU A  73
 None
 1.46A 6mn5D-3dc8A:
undetectable		 6mn5D-3dc8A:
11.26