SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dcd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3dcd GALACTOSE MUTAROTASE
RELATED ENZYME
(Lactobacillus
acidophilus) 		4 / 5 GLU A 124
TYR A 115
PHE A 287
PRO A 254
 None
 1.18A 1dfoB-3dcdA:
undetectable		 1dfoB-3dcdA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3dcd GALACTOSE MUTAROTASE
RELATED ENZYME
(Lactobacillus
acidophilus) 		4 / 5 GLU A 124
TYR A 115
PHE A 287
PRO A 254
 None
 1.18A 1dfoA-3dcdA:
undetectable		 1dfoA-3dcdA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3dcd GALACTOSE MUTAROTASE
RELATED ENZYME
(Lactobacillus
acidophilus) 		4 / 5 GLU A 124
TYR A 115
PHE A 287
PRO A 254
 None
 1.18A 1dfoD-3dcdA:
undetectable		 1dfoD-3dcdA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3dcd GALACTOSE MUTAROTASE
RELATED ENZYME
(Lactobacillus
acidophilus) 		4 / 5 GLU A 124
TYR A 115
PHE A 287
PRO A 254
 None
 1.18A 1dfoC-3dcdA:
undetectable		 1dfoC-3dcdA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 3dcd GALACTOSE MUTAROTASE
RELATED ENZYME
(Lactobacillus
acidophilus) 		4 / 6 TYR A 207
GLU A 253
PRO A 144
VAL A 250
 None
 1.36A 1q13A-3dcdA:
undetectable		 1q13A-3dcdA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 3dcd GALACTOSE MUTAROTASE
RELATED ENZYME
(Lactobacillus
acidophilus) 		3 / 3 TYR A 249
ARG A  77
GLN A  72
 None
 0.98A 1tw4A-3dcdA:
1.6		 1tw4A-3dcdA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3dcd GALACTOSE MUTAROTASE
RELATED ENZYME
(Lactobacillus
acidophilus) 		4 / 6 GLU A 124
TYR A 115
PHE A 287
PRO A 254
 None
 1.22A 2vmyA-3dcdA:
undetectable		 2vmyA-3dcdA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9W_A_PXLA1197_1
(ASPARTATE
AMINOTRANSFERASE)		 3dcd GALACTOSE MUTAROTASE
RELATED ENZYME
(Lactobacillus
acidophilus) 		5 / 11 GLU A 154
PRO A 149
THR A  29
SER A 293
ASN A 223
 None
 1.25A 2z9wA-3dcdA:
undetectable		 2z9wA-3dcdA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9W_B_PXLB1197_1
(ASPARTATE
AMINOTRANSFERASE)		 3dcd GALACTOSE MUTAROTASE
RELATED ENZYME
(Lactobacillus
acidophilus) 		5 / 11 GLU A 154
PRO A 149
THR A  29
SER A 293
ASN A 223
 None
 1.25A 2z9wB-3dcdA:
undetectable		 2z9wB-3dcdA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 3dcd GALACTOSE MUTAROTASE
RELATED ENZYME
(Lactobacillus
acidophilus) 		4 / 6 ASP A 262
LEU A 174
ASP A 260
LEU A  56
 None
 1.26A 3bj8C-3dcdA:
undetectable
3bj8D-3dcdA:
undetectable		 3bj8C-3dcdA:
18.57
3bj8D-3dcdA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 3dcd GALACTOSE MUTAROTASE
RELATED ENZYME
(Lactobacillus
acidophilus) 		4 / 8 TYR A 291
VAL A 250
LEU A 148
PRO A 149
 None
 1.05A 3jq7C-3dcdA:
undetectable		 3jq7C-3dcdA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 3dcd GALACTOSE MUTAROTASE
RELATED ENZYME
(Lactobacillus
acidophilus) 		5 / 12 ARG A 112
PHE A 111
VAL A 129
PHE A 109
GLU A  84
 None
 1.32A 4bvaA-3dcdA:
undetectable		 4bvaA-3dcdA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_B_T3B1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 3dcd GALACTOSE MUTAROTASE
RELATED ENZYME
(Lactobacillus
acidophilus) 		5 / 12 ARG A 112
PHE A 111
VAL A 129
PHE A 109
GLU A  84
 None
 1.27A 4bvaB-3dcdA:
undetectable		 4bvaB-3dcdA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_1
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 3dcd GALACTOSE MUTAROTASE
RELATED ENZYME
(Lactobacillus
acidophilus) 		4 / 5 HIS A 292
THR A  29
GLU A  31
HIS A 152
 None
 1.49A 4hvcB-3dcdA:
0.2		 4hvcB-3dcdA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 3dcd GALACTOSE MUTAROTASE
RELATED ENZYME
(Lactobacillus
acidophilus) 		5 / 12 GLY A 238
HIS A 143
PHE A 146
ILE A 252
PHE A 287
 None
 1.33A 4wh5A-3dcdA:
undetectable		 4wh5A-3dcdA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3dcd GALACTOSE MUTAROTASE
RELATED ENZYME
(Lactobacillus
acidophilus) 		4 / 6 GLY A 145
ASP A   2
ILE A   5
TYR A 115
 None
 0.83A 5iwuA-3dcdA:
undetectable		 5iwuA-3dcdA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3dcd GALACTOSE MUTAROTASE
RELATED ENZYME
(Lactobacillus
acidophilus) 		4 / 6 GLY A 211
ASN A 214
ARG A 210
ARG A 169
 None
 1.22A 6dwdA-3dcdA:
undetectable
6dwdC-3dcdA:
undetectable		 6dwdA-3dcdA:
20.00
6dwdC-3dcdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3dcd GALACTOSE MUTAROTASE
RELATED ENZYME
(Lactobacillus
acidophilus) 		4 / 5 GLY A 211
ASN A 214
ARG A 210
ARG A 169
 None
 1.25A 6dwdB-3dcdA:
undetectable
6dwdD-3dcdA:
undetectable		 6dwdB-3dcdA:
20.00
6dwdD-3dcdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3dcd GALACTOSE MUTAROTASE
RELATED ENZYME
(Lactobacillus
acidophilus) 		4 / 5 GLY A 211
ASN A 214
ASP A 213
ARG A 210
 None
 1.38A 6dwdB-3dcdA:
undetectable
6dwdD-3dcdA:
undetectable		 6dwdB-3dcdA:
20.00
6dwdD-3dcdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3dcd GALACTOSE MUTAROTASE
RELATED ENZYME
(Lactobacillus
acidophilus) 		4 / 5 ARG A 210
GLY A 211
ASN A 214
ASP A 213
 None
 1.40A 6dwjB-3dcdA:
undetectable
6dwjD-3dcdA:
undetectable		 6dwjB-3dcdA:
20.00
6dwjD-3dcdA:
20.00