SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dcf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 3dcf TRANSCRIPTIONAL
REGULATOR OF THE
TETR/ACRR FAMILY
(Thermobifida
fusca) 		5 / 12 MET A 154
LEU A 157
GLU A 166
ILE A  96
LEU A 111
 None
 1.22A 1g50B-3dcfA:
undetectable		 1g50B-3dcfA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3dcf TRANSCRIPTIONAL
REGULATOR OF THE
TETR/ACRR FAMILY
(Thermobifida
fusca) 		5 / 12 ILE A 118
TYR A 187
GLY A 181
LEU A 180
HIS A 114
 None
 1.04A 2y7kD-3dcfA:
undetectable		 2y7kD-3dcfA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3dcf TRANSCRIPTIONAL
REGULATOR OF THE
TETR/ACRR FAMILY
(Thermobifida
fusca) 		4 / 5 LEU A 111
LEU A 180
GLY A 181
THR A 115
 None
 0.80A 3si7C-3dcfA:
undetectable
3si7D-3dcfA:
undetectable		 3si7C-3dcfA:
21.11
3si7D-3dcfA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 3dcf TRANSCRIPTIONAL
REGULATOR OF THE
TETR/ACRR FAMILY
(Thermobifida
fusca) 		3 / 3 THR A  40
ASN A 125
PHE A 128
 None
 0.75A 4pd9A-3dcfA:
undetectable		 4pd9A-3dcfA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3dcf TRANSCRIPTIONAL
REGULATOR OF THE
TETR/ACRR FAMILY
(Thermobifida
fusca) 		4 / 7 THR A 206
LEU A 209
LEU A 111
THR A 186
 None
 0.93A 4z90A-3dcfA:
3.4
4z90B-3dcfA:
3.4
4z90C-3dcfA:
3.1
4z90D-3dcfA:
3.5
4z90E-3dcfA:
3.4		 4z90A-3dcfA:
23.31
4z90B-3dcfA:
23.31
4z90C-3dcfA:
23.31
4z90D-3dcfA:
23.31
4z90E-3dcfA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 3dcf TRANSCRIPTIONAL
REGULATOR OF THE
TETR/ACRR FAMILY
(Thermobifida
fusca) 		3 / 3 LEU A 110
LEU A 157
ARG A 106
 None
 0.57A 6fgcA-3dcfA:
undetectable		 6fgcA-3dcfA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 3dcf TRANSCRIPTIONAL
REGULATOR OF THE
TETR/ACRR FAMILY
(Thermobifida
fusca) 		3 / 3 LEU A 110
LEU A 157
ARG A 106
 None
 0.59A 6fgdA-3dcfA:
undetectable		 6fgdA-3dcfA:
20.88