SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dcm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3dcm UNCHARACTERIZED
PROTEIN TM_1570
(Thermotoga
maritima) 		4 / 4 ILE X 108
LEU X 137
VAL X   7
ALA X  35
 None
 1.01A 1mz9A-3dcmX:
undetectable		 1mz9A-3dcmX:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3dcm UNCHARACTERIZED
PROTEIN TM_1570
(Thermotoga
maritima) 		5 / 12 THR X  24
LEU X 140
VAL X   7
VAL X 172
VAL X  85
 None
SAM  X5452 (-4.5A)
None
SAM  X5452 (-3.7A)
None
 1.21A 1q23H-3dcmX:
undetectable
1q23I-3dcmX:
undetectable		 1q23H-3dcmX:
23.25
1q23I-3dcmX:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 3dcm UNCHARACTERIZED
PROTEIN TM_1570
(Thermotoga
maritima) 		6 / 12 GLY X 141
GLY X 145
ILE X 161
LEU X 170
VAL X 172
ALA X 175
 SAM  X5452 (-3.1A)
SAM  X5452 (-3.7A)
SAM  X5452 (-3.7A)
SAM  X5452 (-4.2A)
SAM  X5452 (-3.7A)
SAM  X5452 (-3.3A)
 0.41A 1v2xA-3dcmX:
13.4		 1v2xA-3dcmX:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 3dcm UNCHARACTERIZED
PROTEIN TM_1570
(Thermotoga
maritima) 		6 / 11 THR X 111
GLY X 141
GLY X 145
ILE X 161
LEU X 170
ALA X 175
 SAM  X5452 (-3.9A)
SAM  X5452 (-3.1A)
SAM  X5452 (-3.7A)
SAM  X5452 (-3.7A)
SAM  X5452 (-4.2A)
SAM  X5452 (-3.3A)
 0.49A 1x7pA-3dcmX:
14.3
1x7pB-3dcmX:
14.5		 1x7pA-3dcmX:
22.57
1x7pB-3dcmX:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 3dcm UNCHARACTERIZED
PROTEIN TM_1570
(Thermotoga
maritima) 		6 / 10 THR X 111
GLY X 141
GLY X 145
ILE X 161
LEU X 170
ALA X 175
 SAM  X5452 (-3.9A)
SAM  X5452 (-3.1A)
SAM  X5452 (-3.7A)
SAM  X5452 (-3.7A)
SAM  X5452 (-4.2A)
SAM  X5452 (-3.3A)
 0.29A 1x7pA-3dcmX:
14.3
1x7pB-3dcmX:
14.5		 1x7pA-3dcmX:
22.57
1x7pB-3dcmX:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 3dcm UNCHARACTERIZED
PROTEIN TM_1570
(Thermotoga
maritima) 		4 / 6 ASN X  28
LEU X   9
LEU X  87
ILE X  34
 None
 0.86A 1z95A-3dcmX:
undetectable		 1z95A-3dcmX:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 3dcm UNCHARACTERIZED
PROTEIN TM_1570
(Thermotoga
maritima) 		3 / 3 SER X  23
TYR X  12
HIS X  11
 None
 0.75A 2r2vD-3dcmX:
undetectable		 2r2vD-3dcmX:
11.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 3dcm UNCHARACTERIZED
PROTEIN TM_1570
(Thermotoga
maritima) 		6 / 11 GLY X 141
ILE X 178
LEU X 170
SER X 171
VAL X 172
ALA X 175
 SAM  X5452 (-3.1A)
None
SAM  X5452 (-4.2A)
SAM  X5452 (-4.9A)
SAM  X5452 (-3.7A)
SAM  X5452 (-3.3A)
 1.22A 3dcmX-3dcmX:
38.2		 3dcmX-3dcmX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 3dcm UNCHARACTERIZED
PROTEIN TM_1570
(Thermotoga
maritima) 		11 / 11 THR X 111
ALA X 113
GLY X 141
GLY X 145
ILE X 161
ASN X 168
LEU X 170
SER X 171
VAL X 172
ARG X 173
ALA X 175
 SAM  X5452 (-3.9A)
SAM  X5452 (-3.5A)
SAM  X5452 (-3.1A)
SAM  X5452 (-3.7A)
SAM  X5452 (-3.7A)
SAM  X5452 (-3.9A)
SAM  X5452 (-4.2A)
SAM  X5452 (-4.9A)
SAM  X5452 (-3.7A)
SAM  X5452 ( 4.0A)
SAM  X5452 (-3.3A)
 0.00A 3dcmX-3dcmX:
38.2		 3dcmX-3dcmX:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 3dcm UNCHARACTERIZED
PROTEIN TM_1570
(Thermotoga
maritima) 		5 / 11 ALA X 113
GLY X 141
ILE X 161
LEU X 170
VAL X 172
 SAM  X5452 (-3.5A)
SAM  X5452 (-3.1A)
SAM  X5452 (-3.7A)
SAM  X5452 (-4.2A)
SAM  X5452 (-3.7A)
 0.52A 3gyqB-3dcmX:
14.3		 3gyqB-3dcmX:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 3dcm UNCHARACTERIZED
PROTEIN TM_1570
(Thermotoga
maritima) 		5 / 12 GLY X 141
GLY X 145
ILE X 161
LEU X 170
VAL X 172
 SAM  X5452 (-3.1A)
SAM  X5452 (-3.7A)
SAM  X5452 (-3.7A)
SAM  X5452 (-4.2A)
SAM  X5452 (-3.7A)
 0.47A 3nk7B-3dcmX:
14.2		 3nk7B-3dcmX:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3dcm UNCHARACTERIZED
PROTEIN TM_1570
(Thermotoga
maritima) 		4 / 7 GLU X 149
GLU X 152
ARG X 116
GLY X 145
 None
None
None
SAM  X5452 (-3.7A)
 1.04A 4fgzA-3dcmX:
2.3		 4fgzA-3dcmX:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 3dcm UNCHARACTERIZED
PROTEIN TM_1570
(Thermotoga
maritima) 		4 / 7 ASN X  28
LEU X   9
LEU X  87
ILE X  34
 None
 0.97A 4okwA-3dcmX:
undetectable		 4okwA-3dcmX:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 3dcm UNCHARACTERIZED
PROTEIN TM_1570
(Thermotoga
maritima) 		3 / 3 LEU X 107
ASP X 155
TYR X 156
 None
 0.63A 4qc6B-3dcmX:
undetectable		 4qc6B-3dcmX:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 3dcm UNCHARACTERIZED
PROTEIN TM_1570
(Thermotoga
maritima) 		5 / 9 LEU X 140
GLY X 141
ILE X 161
LEU X 170
VAL X 172
 SAM  X5452 (-4.5A)
SAM  X5452 (-3.1A)
SAM  X5452 (-3.7A)
SAM  X5452 (-4.2A)
SAM  X5452 (-3.7A)
 0.96A 4x3mB-3dcmX:
12.9		 4x3mB-3dcmX:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 3dcm UNCHARACTERIZED
PROTEIN TM_1570
(Thermotoga
maritima) 		3 / 3 GLU X   3
LYS X  44
ASN X  42
 None
 0.97A 4y1dA-3dcmX:
undetectable
4y1dD-3dcmX:
undetectable		 4y1dA-3dcmX:
18.75
4y1dD-3dcmX:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 3dcm UNCHARACTERIZED
PROTEIN TM_1570
(Thermotoga
maritima) 		6 / 12 THR X 111
GLY X 141
GLY X 145
ILE X 161
LEU X 170
ALA X 175
 SAM  X5452 (-3.9A)
SAM  X5452 (-3.1A)
SAM  X5452 (-3.7A)
SAM  X5452 (-3.7A)
SAM  X5452 (-4.2A)
SAM  X5452 (-3.3A)
 0.47A 5l0zA-3dcmX:
13.8		 5l0zA-3dcmX:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 3dcm UNCHARACTERIZED
PROTEIN TM_1570
(Thermotoga
maritima) 		6 / 10 THR X 111
GLY X 141
GLY X 145
ILE X 161
LEU X 170
ALA X 175
 SAM  X5452 (-3.9A)
SAM  X5452 (-3.1A)
SAM  X5452 (-3.7A)
SAM  X5452 (-3.7A)
SAM  X5452 (-4.2A)
SAM  X5452 (-3.3A)
 0.54A 5l0zB-3dcmX:
5.8		 5l0zB-3dcmX:
23.15