SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dcx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1CTR_A_TFPA153_1 (CALMODULIN)	3dcx	PROTEIN OF UNKNOWN FUNCTION (DUF1696) WITH PLECKSTRIN-HOMOLOGY DOMAINS (Shewanella loihica)	5 / 9	ILE A 115 GLU A 78 GLU A 80 ALA A 89 VAL A 112	MPD A 5 ( 4.9A) None None None None	1.12A	1ctrA-3dcxA: undetectable	1ctrA-3dcxA: 23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WRL_C_TFPC208_1 (TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES)	3dcx	PROTEIN OF UNKNOWN FUNCTION (DUF1696) WITH PLECKSTRIN-HOMOLOGY DOMAINS (Shewanella loihica)	4 / 5	PHE A 44 LEU A 102 PHE A 46 SER A 123	MPD A 5 ( 3.8A) None None None	1.17A	1wrlC-3dcxA: undetectable	1wrlC-3dcxA: 22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3O02_B_JN3B1_1 (CELL INVASION PROTEIN SIPD)	3dcx	PROTEIN OF UNKNOWN FUNCTION (DUF1696) WITH PLECKSTRIN-HOMOLOGY DOMAINS (Shewanella loihica)	5 / 10	ILE A 52 PHE A 122 ALA A 36 LEU A 23 LEU A 19	None	1.03A	3o02A-3dcxA: undetectable 3o02B-3dcxA: undetectable	3o02A-3dcxA: 19.22 3o02B-3dcxA: 19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U5K_D_08JD4_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	3dcx	PROTEIN OF UNKNOWN FUNCTION (DUF1696) WITH PLECKSTRIN-HOMOLOGY DOMAINS (Shewanella loihica)	4 / 8	VAL A 45 LEU A 19 LEU A 33 ILE A 26	None	0.89A	3u5kD-3dcxA: undetectable	3u5kD-3dcxA: 22.70

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1CTR_A_TFPA153_1","CALMODULIN","3dcx","PROTEIN OF UNKNOWN FUNCTION (DUF1696) WITH PLECKSTRIN-HOMOLOGY DOMAINS","Shewanella loihica",5,"ILE A 115;GLU A  78;GLU A  80;ALA A  89;VAL A 112","MPD A   5 ( 4.9A);None;None;None;None","1.12A","1ctrA-3dcxA:undetectable","1ctrA-3dcxA:23.08"],["1WRL_C_TFPC208_1","TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES","3dcx","PROTEIN OF UNKNOWN FUNCTION (DUF1696) WITH PLECKSTRIN-HOMOLOGY DOMAINS","Shewanella loihica",4,"PHE A  44;LEU A 102;PHE A  46;SER A 123","MPD A   5 ( 3.8A);None;None;None","1.17A","1wrlC-3dcxA:undetectable","1wrlC-3dcxA:22.03"],["3O02_B_JN3B1_1","CELL INVASION PROTEIN SIPD;CELL INVASION PROTEIN SIPD","3dcx","PROTEIN OF UNKNOWN FUNCTION (DUF1696) WITH PLECKSTRIN-HOMOLOGY DOMAINS","Shewanella loihica",5,"ILE A  52;PHE A 122;ALA A  36;LEU A  23;LEU A  19","None","1.03A","3o02A-3dcxA:undetectable;3o02B-3dcxA:undetectable","3o02A-3dcxA:19.22;3o02B-3dcxA:19.22"],["3U5K_D_08JD4_1","BROMODOMAIN-CONTAINING PROTEIN 4","3dcx","PROTEIN OF UNKNOWN FUNCTION (DUF1696) WITH PLECKSTRIN-HOMOLOGY DOMAINS","Shewanella loihica",4,"VAL A  45;LEU A  19;LEU A  33;ILE A  26","None","0.89A","3u5kD-3dcxA:undetectable","3u5kD-3dcxA:22.70"]]