SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dcy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 3dcy REGULATOR PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 139
LEU A   6
PRO A 250
VAL A 252
 None
 1.05A 2dqyC-3dcyA:
undetectable		 2dqyC-3dcyA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 3dcy REGULATOR PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 199
LEU A  87
LEU A 205
SER A 204
GLY A 234
 PO4  A 271 (-3.9A)
None
None
None
None
 1.10A 3g2oA-3dcyA:
undetectable		 3g2oA-3dcyA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3dcy REGULATOR PROTEIN
(Homo
sapiens) 		4 / 7 LEU A   6
LEU A 142
ILE A 240
PHE A   4
 None
 0.91A 3ln1B-3dcyA:
undetectable		 3ln1B-3dcyA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 3dcy REGULATOR PROTEIN
(Homo
sapiens) 		3 / 3 LEU A  70
GLU A  71
SER A  73
 None
 0.77A 4ccqA-3dcyA:
undetectable		 4ccqA-3dcyA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 3dcy REGULATOR PROTEIN
(Homo
sapiens) 		5 / 12 LEU A   6
ALA A   5
LEU A 194
LEU A  46
LEU A 172
 None
 1.24A 4j24D-3dcyA:
undetectable		 4j24D-3dcyA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 3dcy REGULATOR PROTEIN
(Homo
sapiens) 		4 / 8 GLY A  24
GLN A  23
SER A  57
HIS A 198
 None
PO4  A 271 (-4.1A)
None
PO4  A 271 (-3.8A)
 0.94A 4wryA-3dcyA:
undetectable		 4wryA-3dcyA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 3dcy REGULATOR PROTEIN
(Homo
sapiens) 		4 / 5 VAL A  49
LEU A  46
HIS A 262
THR A   7
 None
 1.07A 6dyoA-3dcyA:
undetectable		 6dyoA-3dcyA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3dcy REGULATOR PROTEIN
(Homo
sapiens) 		5 / 9 LEU A 205
SER A 204
PHE A 206
LEU A 226
VAL A   8
 None
 1.08A 6ftpA-3dcyA:
undetectable
6ftpB-3dcyA:
undetectable		 6ftpA-3dcyA:
15.13
6ftpB-3dcyA:
10.00