SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dd6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		4 / 8 SER A 151
VAL A 150
PRO A 154
VAL A  47
 None
 0.88A 1fduB-3dd6A:
undetectable		 1fduB-3dd6A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		5 / 10 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.05A 1fk9A-3dd6A:
undetectable		 1fk9A-3dd6A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		5 / 10 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 0.98A 1fkoA-3dd6A:
undetectable		 1fkoA-3dd6A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		5 / 11 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.09A 1fkpA-3dd6A:
undetectable		 1fkpA-3dd6A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		5 / 9 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.04A 1ikvA-3dd6A:
undetectable		 1ikvA-3dd6A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		5 / 11 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.14A 1jkhA-3dd6A:
undetectable
1jkhB-3dd6A:
undetectable		 1jkhA-3dd6A:
20.00
1jkhB-3dd6A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		5 / 10 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.10A 1lw0A-3dd6A:
undetectable		 1lw0A-3dd6A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		5 / 11 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.16A 1lwcA-3dd6A:
undetectable		 1lwcA-3dd6A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		5 / 9 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 0.99A 1lwfA-3dd6A:
undetectable		 1lwfA-3dd6A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RR8_A_TTCA100_1
(DNA TOPOISOMERASE I)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		4 / 5 GLU A  71
ARG A  12
ASP A 175
THR A 127
 None
 1.49A 1rr8C-3dd6A:
undetectable		 1rr8C-3dd6A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		5 / 9 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.15A 1vrtA-3dd6A:
undetectable		 1vrtA-3dd6A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		4 / 8 ARG A  86
THR A  35
THR A  70
ALA A  69
 SO4  A 301 ( 3.8A)
None
None
None
 0.85A 2a1hA-3dd6A:
undetectable
2a1hB-3dd6A:
undetectable		 2a1hA-3dd6A:
23.10
2a1hB-3dd6A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		5 / 10 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.13A 2hndA-3dd6A:
undetectable		 2hndA-3dd6A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		5 / 10 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.15A 2hnyA-3dd6A:
undetectable		 2hnyA-3dd6A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		4 / 8 VAL A 118
GLY A 124
THR A 125
ALA A 128
 None
SO4  A 301 (-3.5A)
SO4  A 301 (-2.7A)
None
 0.65A 3aruA-3dd6A:
undetectable		 3aruA-3dd6A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP0_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		5 / 9 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.12A 3lp0A-3dd6A:
undetectable		 3lp0A-3dd6A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		5 / 10 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.09A 3lp1A-3dd6A:
undetectable		 3lp1A-3dd6A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		5 / 11 LEU A  93
ILE A 191
ALA A 133
ALA A 128
ALA A 161
 None
 1.12A 3mdtB-3dd6A:
undetectable		 3mdtB-3dd6A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		5 / 12 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 0.93A 3mecA-3dd6A:
undetectable		 3mecA-3dd6A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		5 / 12 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 0.97A 3medA-3dd6A:
undetectable
3medB-3dd6A:
undetectable		 3medA-3dd6A:
19.82
3medB-3dd6A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		5 / 10 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.10A 3qipA-3dd6A:
undetectable		 3qipA-3dd6A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		4 / 4 ALA A 184
VAL A 186
ASP A 187
LEU A 218
 None
 1.43A 4e7gA-3dd6A:
undetectable		 4e7gA-3dd6A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		4 / 6 ARG A  86
GLY A  85
GLU A  77
GLN A 202
 SO4  A 301 ( 3.8A)
None
None
None
 1.12A 4g0vB-3dd6A:
undetectable		 4g0vB-3dd6A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		5 / 12 LEU A 107
LEU A  98
MET A 137
VAL A 138
VAL A 199
 None
 1.47A 4okxA-3dd6A:
undetectable		 4okxA-3dd6A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		5 / 11 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.17A 5hbmA-3dd6A:
undetectable		 5hbmA-3dd6A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		3 / 3 VAL A  32
SER A 163
MET A 192
 None
 0.94A 5ikqA-3dd6A:
undetectable		 5ikqA-3dd6A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		5 / 12 ILE A  43
PHE A 141
ALA A 140
ALA A 133
ILE A 130
 None
 1.05A 5veuB-3dd6A:
undetectable		 5veuB-3dd6A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		5 / 10 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.15A 6bsgA-3dd6A:
undetectable		 6bsgA-3dd6A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		5 / 10 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.21A 6bsiA-3dd6A:
undetectable		 6bsiA-3dd6A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3dd6 RIBONUCLEASE PH
(Bacillus
anthracis) 		5 / 10 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.16A 6bsjA-3dd6A:
undetectable		 6bsjA-3dd6A:
16.80