SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ddd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 3ddd PUTATIVE
ACETYLTRANSFERASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A  12
ILE A  11
ARG A 174
 None
 0.76A 1cd2A-3dddA:
undetectable		 1cd2A-3dddA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3ddd PUTATIVE
ACETYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A  39
PHE A  35
ALA A   6
ILE A  17
 None
 0.97A 1oniB-3dddA:
undetectable
1oniC-3dddA:
undetectable		 1oniB-3dddA:
20.14
1oniC-3dddA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3ddd PUTATIVE
ACETYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 8 ALA A  21
TYR A  22
GLY A  57
GLY A  59
 COA  A 300 (-3.5A)
COA  A 300 (-3.3A)
None
None
 0.78A 1rukH-3dddA:
undetectable
1rukL-3dddA:
undetectable		 1rukH-3dddA:
17.63
1rukL-3dddA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 3ddd PUTATIVE
ACETYLTRANSFERASE
(Pyrococcus
horikoshii) 		3 / 3 LEU A 114
PHE A  89
ARG A 246
 COA  A 300 (-4.1A)
None
None
 0.68A 1xdkB-3dddA:
undetectable		 1xdkB-3dddA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 3ddd PUTATIVE
ACETYLTRANSFERASE
(Pyrococcus
horikoshii) 		3 / 3 LEU A 114
PHE A  89
ARG A 246
 COA  A 300 (-4.1A)
None
None
 0.68A 1xdkF-3dddA:
undetectable		 1xdkF-3dddA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 3ddd PUTATIVE
ACETYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 6 ALA A 181
GLU A 182
TRP A 151
ARG A 203
 None
 1.19A 2ouzA-3dddA:
undetectable		 2ouzA-3dddA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 3ddd PUTATIVE
ACETYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 8 LEU A  93
ILE A  70
PHE A  62
GLY A  45
 None
 0.92A 3b9lA-3dddA:
undetectable		 3b9lA-3dddA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3ddd PUTATIVE
ACETYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 7 GLY A  85
VAL A  75
ILE A   3
GLN A  -1
 COA  A 300 (-3.6A)
COA  A 300 ( 4.3A)
EDO  A 301 (-4.7A)
None
 0.91A 3fi0P-3dddA:
undetectable		 3fi0P-3dddA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 3ddd PUTATIVE
ACETYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 5 ALA A 199
GLU A 182
GLU A 184
ALA A 181
 None
 1.39A 3r9tC-3dddA:
undetectable		 3r9tC-3dddA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ddd PUTATIVE
ACETYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 155
ALA A 199
LEU A 197
PHE A 186
ALA A 181
 None
 1.17A 3uvvB-3dddA:
undetectable		 3uvvB-3dddA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 3ddd PUTATIVE
ACETYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 9 ALA A 176
ALA A 212
ILE A 208
GLY A 187
ILE A 194
 None
 1.08A 4eatB-3dddA:
undetectable		 4eatB-3dddA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 3ddd PUTATIVE
ACETYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 5 ILE A 221
ASN A 226
TYR A 260
ILE A 263
 None
 1.06A 4jtpA-3dddA:
undetectable		 4jtpA-3dddA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3ddd PUTATIVE
ACETYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A 205
GLY A 187
LEU A 168
ALA A 199
TYR A 260
 None
 1.04A 4lg1A-3dddA:
undetectable		 4lg1A-3dddA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3ddd PUTATIVE
ACETYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A 205
GLY A 187
LEU A 168
ALA A 199
TYR A 260
 None
 1.01A 4lg1B-3dddA:
undetectable		 4lg1B-3dddA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3ddd PUTATIVE
ACETYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A 205
GLY A 187
LEU A 168
ALA A 199
TYR A 260
 None
 1.03A 4lg1C-3dddA:
undetectable		 4lg1C-3dddA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 3ddd PUTATIVE
ACETYLTRANSFERASE
(Pyrococcus
horikoshii) 		3 / 3 ASP A 106
TYR A 266
TRP A  69
 None
 1.21A 4p7nA-3dddA:
undetectable		 4p7nA-3dddA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ddd PUTATIVE
ACETYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 7 GLU A  54
ILE A  17
LEU A 114
ILE A  84
 None
None
COA  A 300 (-4.1A)
COA  A 300 ( 4.6A)
 0.87A 4xumA-3dddA:
undetectable		 4xumA-3dddA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 3ddd PUTATIVE
ACETYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 8 TYR A 260
GLY A 262
TYR A 190
GLY A 187
 None
None
EDO  A 302 (-4.5A)
None
 0.90A 5albL-3dddA:
undetectable		 5albL-3dddA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3ddd PUTATIVE
ACETYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 7 PHE A  62
VAL A 167
ILE A 263
SER A  34
 None
 0.77A 5vkqA-3dddA:
undetectable
5vkqD-3dddA:
undetectable		 5vkqA-3dddA:
9.92
5vkqD-3dddA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3ddd PUTATIVE
ACETYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 7 SER A  34
PHE A  62
VAL A 167
ILE A 263
 None
 0.80A 5vkqA-3dddA:
undetectable
5vkqB-3dddA:
undetectable		 5vkqA-3dddA:
9.92
5vkqB-3dddA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3ddd PUTATIVE
ACETYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 7 SER A  34
PHE A  62
VAL A 167
ILE A 263
 None
 0.78A 5vkqC-3dddA:
undetectable
5vkqD-3dddA:
undetectable		 5vkqC-3dddA:
9.92
5vkqD-3dddA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 3ddd PUTATIVE
ACETYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 8 GLY A 185
ARG A 164
VAL A 152
ASP A 156
 None
 1.00A 5vlmA-3dddA:
undetectable		 5vlmA-3dddA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3ddd PUTATIVE
ACETYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  71
ILE A  95
TYR A   5
LEU A  47
GLY A  59
 None
None
EDO  A 301 ( 4.5A)
EDO  A 301 ( 4.8A)
None
 0.88A 5wyqB-3dddA:
undetectable		 5wyqB-3dddA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 3ddd PUTATIVE
ACETYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 187
GLY A 185
ALA A 181
ILE A 194
LEU A 197
 None
 1.13A 6b3aA-3dddA:
10.6		 6b3aA-3dddA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 3ddd PUTATIVE
ACETYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 187
GLY A 185
ALA A 181
ILE A 194
LEU A 197
 None
 1.12A 6b3bA-3dddA:
10.7		 6b3bA-3dddA:
19.88