SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ddh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 3ddh PUTATIVE HALOACID
DEHALOGENASE-LIKE
FAMILY HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 11 LEU A 229
LEU A 189
LEU A 175
VAL A 220
ILE A 185
 None
 1.07A 1ee2A-3ddhA:
5.7		 1ee2A-3ddhA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 3ddh PUTATIVE HALOACID
DEHALOGENASE-LIKE
FAMILY HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 11 LEU A 229
LEU A 189
LEU A 175
VAL A 220
ILE A 185
 None
 1.12A 1ee2B-3ddhA:
5.9		 1ee2B-3ddhA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3ddh PUTATIVE HALOACID
DEHALOGENASE-LIKE
FAMILY HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 7 VAL A 196
GLY A 178
THR A  15
ILE A 198
 None
 0.68A 1gtnC-3ddhA:
undetectable
1gtnD-3ddhA:
undetectable		 1gtnC-3ddhA:
14.68
1gtnD-3ddhA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 3ddh PUTATIVE HALOACID
DEHALOGENASE-LIKE
FAMILY HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 7 SER A  68
ILE A  67
ASN A  54
ILE A  57
 GOL  A 235 ( 4.9A)
None
None
None
 0.84A 1yc5A-3ddhA:
5.1		 1yc5A-3ddhA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 3ddh PUTATIVE HALOACID
DEHALOGENASE-LIKE
FAMILY HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 8 LEU A  34
TYR A  37
ILE A  85
ILE A  86
 None
 0.77A 2bu8A-3ddhA:
undetectable		 2bu8A-3ddhA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 3ddh PUTATIVE HALOACID
DEHALOGENASE-LIKE
FAMILY HYDROLASE
(Bacteroides
thetaiotaomicron) 		3 / 3 SER A 140
THR A 126
GLN A 133
 None
CL  A 233 ( 4.9A)
None
 0.81A 2fk8A-3ddhA:
undetectable		 2fk8A-3ddhA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3ddh PUTATIVE HALOACID
DEHALOGENASE-LIKE
FAMILY HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 8 LEU A 223
VAL A 177
GLY A 178
GLN A 219
 None
 0.76A 2wd9B-3ddhA:
3.4		 2wd9B-3ddhA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3ddh PUTATIVE HALOACID
DEHALOGENASE-LIKE
FAMILY HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 10 VAL A 220
LEU A 175
VAL A 177
LEU A 226
LYS A   2
 None
 0.97A 3gwxA-3ddhA:
undetectable		 3gwxA-3ddhA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 3ddh PUTATIVE HALOACID
DEHALOGENASE-LIKE
FAMILY HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ALA A  73
ILE A  89
LEU A  34
ALA A  46
 None
 0.87A 3r9sA-3ddhA:
undetectable		 3r9sA-3ddhA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3ddh PUTATIVE HALOACID
DEHALOGENASE-LIKE
FAMILY HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A   7
THR A 156
PRO A 171
GLY A 192
LEU A 191
 None
 1.35A 5m50B-3ddhA:
5.2		 5m50B-3ddhA:
21.27