SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ddn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 11 PRO A 173
LEU A 187
VAL A 147
TYR A 171
GLY A 146
 None
 1.44A 1fkpA-3ddnA:
undetectable		 1fkpA-3ddnA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A   9
GLY A 293
VAL A  18
ALA A 288
SER A  98
 None
 1.40A 1nbhD-3ddnA:
5.3		 1nbhD-3ddnA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 502
ASP A 503
PRO A 507
VAL A 506
 None
 0.98A 2aoiB-3ddnA:
undetectable		 2aoiB-3ddnA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 8 LEU A   8
LEU A  39
VAL A  60
VAL A  50
 None
 0.93A 2bdmA-3ddnA:
undetectable		 2bdmA-3ddnA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 523
LEU A 475
ILE A 471
ALA A 513
 None
 0.73A 2i2zA-3ddnA:
undetectable		 2i2zA-3ddnA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 ILE A 459
ILE A 514
LEU A 457
ASN A 456
VAL A 480
 None
 1.14A 2nnhB-3ddnA:
undetectable		 2nnhB-3ddnA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 6 ILE A 400
ARG A 366
PRO A 346
SER A 342
 None
 1.03A 2qd3B-3ddnA:
4.7		 2qd3B-3ddnA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 412
SER A 428
THR A 430
ASP A 449
ILE A 443
 None
 1.12A 3a35A-3ddnA:
undetectable		 3a35A-3ddnA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 8 VAL A 169
THR A 144
PHE A 141
GLY A 165
ALA A 166
 None
 0.97A 3aruA-3ddnA:
undetectable		 3aruA-3ddnA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  93
ALA A  73
ILE A   9
LEU A 304
ILE A  69
 None
 0.97A 3clbC-3ddnA:
undetectable		 3clbC-3ddnA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A  49
LEU A  67
ALA A  47
LEU A   8
VAL A  56
 None
 1.20A 3e22B-3ddnA:
2.5		 3e22B-3ddnA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A  49
LEU A  67
ALA A  47
LEU A   8
VAL A  56
 None
 1.20A 3e22D-3ddnA:
undetectable		 3e22D-3ddnA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 233
GLU A 209
ASP A 527
 None
 0.81A 3g2oA-3ddnA:
6.7		 3g2oA-3ddnA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 457
ILE A 514
LEU A 523
ASP A 490
SER A 488
 None
 1.13A 3ko0K-3ddnA:
undetectable
3ko0L-3ddnA:
undetectable
3ko0S-3ddnA:
undetectable
3ko0T-3ddnA:
undetectable		 3ko0K-3ddnA:
8.83
3ko0L-3ddnA:
8.83
3ko0S-3ddnA:
8.83
3ko0T-3ddnA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 HIS A 203
SER A 201
ALA A 103
ILE A 100
LEU A 110
 None
 1.36A 3lcvB-3ddnA:
3.9		 3lcvB-3ddnA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 181
SER A 176
ASP A 172
ALA A 170
GLN A 155
 None
 1.14A 3nmuA-3ddnA:
undetectable
3nmuF-3ddnA:
5.2		 3nmuA-3ddnA:
23.32
3nmuF-3ddnA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 227
GLN A 274
LEU A 111
PRO A 119
 None
 0.85A 3ozwA-3ddnA:
2.2		 3ozwA-3ddnA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 237
VAL A 251
LEU A 219
VAL A 275
ALA A 254
 None
 1.11A 3rr3C-3ddnA:
undetectable		 3rr3C-3ddnA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 237
VAL A 251
LEU A 219
VAL A 275
ALA A 254
 None
 1.12A 3rr3D-3ddnA:
undetectable		 3rr3D-3ddnA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  91
ALA A  71
VAL A  18
ILE A  69
 None
 0.89A 3wsjB-3ddnA:
undetectable		 3wsjB-3ddnA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 213
ALA A 218
VAL A 226
ILE A 214
 None
 0.87A 3wsjB-3ddnA:
undetectable		 3wsjB-3ddnA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 213
ALA A 218
VAL A 251
ILE A 214
 None
 0.91A 3wsjB-3ddnA:
undetectable		 3wsjB-3ddnA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0S_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 11 VAL A 148
LEU A 194
VAL A 202
LEU A 213
THR A 210
 None
 1.25A 4k0sA-3ddnA:
undetectable		 4k0sA-3ddnA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 150
GLY A 151
GLN A 155
ILE A 378
VAL A 385
 None
 0.85A 4ok1A-3ddnA:
undetectable		 4ok1A-3ddnA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 150
GLY A 151
GLN A 155
ILE A 378
VAL A 385
 None
 0.89A 4okwA-3ddnA:
undetectable		 4okwA-3ddnA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 417
GLY A 429
GLY A 335
LEU A 373
GLY A 445
 None
 0.99A 5i73A-3ddnA:
undetectable		 5i73A-3ddnA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 222
VAL A 251
ILE A 227
VAL A 226
 None
 0.82A 5ik1A-3ddnA:
undetectable		 5ik1A-3ddnA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 5 VAL A 315
THR A 383
ASP A 329
LEU A 328
 None
 1.26A 5m0iB-3ddnA:
undetectable		 5m0iB-3ddnA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 242
LEU A 256
ILE A 200
LEU A 219
LEU A 213
 None
 1.13A 5og9B-3ddnA:
undetectable		 5og9B-3ddnA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 214
LEU A 190
LEU A 188
ALA A 170
 None
 0.86A 5y7pE-3ddnA:
undetectable		 5y7pE-3ddnA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 308
ALA A 389
ALA A 391
ILE A 400
LEU A 367
 None
 1.23A 6aybA-3ddnA:
undetectable		 6aybA-3ddnA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 4 HIS A 106
VAL A 229
LEU A 110
ALA A 231
 None
 1.25A 6d8pB-3ddnA:
3.9		 6d8pB-3ddnA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 HIS A 101
ARG A 152
ILE A 100
 None
 0.80A 6fgdA-3ddnA:
3.6		 6fgdA-3ddnA:
22.94