SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ddu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		4 / 6 GLU A 512
ILE A 480
TYR A 473
GLY A 556
 None
None
ACT  A 801 (-4.5A)
None
 1.11A 1maaB-3dduA:
16.4
1maaD-3dduA:
13.9		 1maaB-3dduA:
22.33
1maaD-3dduA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		5 / 10 ASP A 598
ASN A 555
GLY A 472
GLY A 508
GLU A 509
 None
 1.07A 1mehA-3dduA:
undetectable		 1mehA-3dduA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		4 / 7 TYR A   6
ASN A 668
TYR A 630
GLY A 572
 None
 1.35A 1mxgA-3dduA:
undetectable		 1mxgA-3dduA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		5 / 12 ARG A 252
SER A 554
VAL A 580
VAL A 644
HIS A 680
 None
ACT  A 801 ( 2.6A)
None
None
ACT  A 801 (-3.8A)
 1.14A 1x70B-3dduA:
26.6		 1x70B-3dduA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		4 / 8 ASP A 582
GLY A 592
ASP A 598
TYR A 599
 None
 0.97A 2aouA-3dduA:
2.6		 2aouA-3dduA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		5 / 12 LEU A 634
ALA A 576
ILE A 550
ILE A 672
SER A 649
 None
 1.15A 2ejtA-3dduA:
undetectable		 2ejtA-3dduA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		4 / 6 TYR A  90
GLY A  93
TYR A  76
ASP A  72
 None
 1.22A 2g72A-3dduA:
undetectable		 2g72A-3dduA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		4 / 6 LEU A 584
ASN A 565
GLN A 524
PHE A 608
 None
 1.21A 2jn3A-3dduA:
undetectable		 2jn3A-3dduA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		3 / 3 LEU A 647
TYR A 589
GLY A 592
 None
 0.65A 2ocuA-3dduA:
undetectable		 2ocuA-3dduA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		4 / 6 GLY A 507
ILE A 478
GLU A 509
ILE A 480
 None
 0.87A 3a7eA-3dduA:
2.5		 3a7eA-3dduA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		5 / 12 LEU A 634
ALA A 576
ILE A 550
ILE A 672
SER A 649
 None
 1.18A 3axtA-3dduA:
2.1		 3axtA-3dduA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		5 / 12 TYR A 473
SER A 554
VAL A 580
VAL A 644
HIS A 680
 ACT  A 801 (-4.5A)
ACT  A 801 ( 2.6A)
None
None
ACT  A 801 (-3.8A)
 0.32A 3bjmA-3dduA:
25.5		 3bjmA-3dduA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		5 / 12 TYR A 473
SER A 554
VAL A 580
VAL A 644
HIS A 680
 ACT  A 801 (-4.5A)
ACT  A 801 ( 2.6A)
None
None
ACT  A 801 (-3.8A)
 0.33A 3bjmB-3dduA:
25.2		 3bjmB-3dduA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		5 / 12 LEU A 114
ASN A 117
GLN A  97
LEU A 127
LEU A 119
 None
 1.36A 3fsuA-3dduA:
undetectable		 3fsuA-3dduA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		3 / 3 ASP A 642
SER A 148
ARG A 128
 None
 0.87A 3loqA-3dduA:
undetectable		 3loqA-3dduA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		5 / 11 VAL A 580
PHE A 527
GLY A 475
GLY A 507
ILE A 478
 None
 1.42A 3owxA-3dduA:
2.6
3owxB-3dduA:
undetectable		 3owxA-3dduA:
15.21
3owxB-3dduA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		5 / 12 TYR A 473
SER A 554
VAL A 580
VAL A 644
HIS A 680
 ACT  A 801 (-4.5A)
ACT  A 801 ( 2.6A)
None
None
ACT  A 801 (-3.8A)
 0.25A 3w2tA-3dduA:
26.2		 3w2tA-3dduA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		5 / 12 TYR A 473
SER A 554
VAL A 580
VAL A 644
HIS A 680
 ACT  A 801 (-4.5A)
ACT  A 801 ( 2.6A)
None
None
ACT  A 801 (-3.8A)
 0.25A 3w2tB-3dduA:
26.2		 3w2tB-3dduA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		4 / 6 HIS A  79
HIS A 409
GLU A 393
SER A 386
 None
 1.33A 4apjA-3dduA:
undetectable
4apjP-3dduA:
undetectable		 4apjA-3dduA:
22.52
4apjP-3dduA:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		6 / 12 ARG A 252
TYR A 473
SER A 554
VAL A 580
VAL A 644
HIS A 680
 None
ACT  A 801 (-4.5A)
ACT  A 801 ( 2.6A)
None
None
ACT  A 801 (-3.8A)
 1.00A 4ffwA-3dduA:
14.5		 4ffwA-3dduA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		5 / 12 GLY A 254
TYR A 473
SER A 554
TYR A 599
VAL A 644
 552  A 901 (-4.4A)
ACT  A 801 (-4.5A)
ACT  A 801 ( 2.6A)
None
None
 0.98A 4ffwB-3dduA:
10.6		 4ffwB-3dduA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		5 / 12 TYR A 473
SER A 554
VAL A 580
VAL A 644
HIS A 680
 ACT  A 801 (-4.5A)
ACT  A 801 ( 2.6A)
None
None
ACT  A 801 (-3.8A)
 0.31A 4ffwB-3dduA:
10.6		 4ffwB-3dduA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		5 / 11 HIS A 515
PHE A 476
ILE A 478
GLY A 556
GLY A 553
 None
552  A 901 (-3.5A)
None
None
None
 1.40A 4fglA-3dduA:
undetectable
4fglB-3dduA:
undetectable		 4fglA-3dduA:
15.77
4fglB-3dduA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		5 / 12 PHE A 476
PHE A 586
GLY A 552
LEU A 558
PHE A 527
 552  A 901 (-3.5A)
None
None
None
None
 1.16A 4kykA-3dduA:
2.7
4kykB-3dduA:
1.5		 4kykA-3dduA:
13.66
4kykB-3dduA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		4 / 6 PHE A 173
MET A 235
ILE A 591
ARG A 643
 552  A 901 (-3.5A)
552  A 901 (-3.6A)
552  A 901 ( 4.2A)
552  A 901 (-3.9A)
 1.31A 4mk4B-3dduA:
4.3		 4mk4B-3dduA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		5 / 12 LEU A 470
ALA A 534
ILE A 454
ALA A 500
ILE A 440
 None
 0.93A 4o2bD-3dduA:
3.3		 4o2bD-3dduA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		4 / 8 SER A 604
ALA A 521
LEU A 520
GLY A 600
 None
 0.94A 4xk8a-3dduA:
undetectable		 4xk8a-3dduA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_C_RAUC400_1
(IMINE REDUCTASE)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		5 / 12 TYR A 630
GLY A 557
VAL A 620
LEU A 635
MET A 633
 None
 1.46A 5g6sB-3dduA:
undetectable
5g6sC-3dduA:
undetectable		 5g6sB-3dduA:
17.63
5g6sC-3dduA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		4 / 6 VAL A 455
VAL A 379
SER A 400
ILE A 382
 ACT  A 802 ( 4.3A)
None
None
None
 1.09A 5jw1B-3dduA:
undetectable		 5jw1B-3dduA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		5 / 10 PRO A 623
LEU A 656
ILE A 653
VAL A 574
PRO A 568
 None
 1.25A 5m0oA-3dduA:
undetectable		 5m0oA-3dduA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_1
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		5 / 12 GLY A 369
PHE A 375
LEU A 412
ASP A 365
TYR A 385
 None
 1.50A 5nknA-3dduA:
undetectable		 5nknA-3dduA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		5 / 12 TYR A 473
SER A 554
VAL A 580
VAL A 644
HIS A 680
 ACT  A 801 (-4.5A)
ACT  A 801 ( 2.6A)
None
None
ACT  A 801 (-3.8A)
 0.27A 6b1eB-3dduA:
25.7		 6b1eB-3dduA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		3 / 3 TYR A  86
HIS A  79
PHE A 395
 None
 1.01A 6esmA-3dduA:
undetectable		 6esmA-3dduA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		5 / 12 ASN A 205
ARG A 170
GLN A 193
GLU A 201
GLY A 199
 None
 1.28A 6gnfA-3dduA:
5.4		 6gnfA-3dduA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens) 		5 / 12 ASN A 205
ARG A 170
GLN A 193
GLU A 201
GLY A 199
 None
 1.26A 6gnfC-3dduA:
3.4		 6gnfC-3dduA:
22.04