SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dea'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 3dea CUTINASE
(Colletotrichum
gloeosporioides) 		5 / 10 GLY A 159
VAL A 131
LEU A  75
TYR A  79
ALA A 129
 None
 1.31A 1pbcA-3deaA:
undetectable		 1pbcA-3deaA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 3dea CUTINASE
(Colletotrichum
gloeosporioides) 		6 / 12 ILE A 157
ILE A 146
ILE A 175
PHE A 178
VAL A 161
LEU A 162
 None
 1.07A 1qhsA-3deaA:
3.5		 1qhsA-3deaA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 3dea CUTINASE
(Colletotrichum
gloeosporioides) 		5 / 12 ARG A 116
ILE A 153
ILE A 157
ALA A  54
GLU A 113
 None
 1.15A 2j0dA-3deaA:
undetectable		 2j0dA-3deaA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 3dea CUTINASE
(Colletotrichum
gloeosporioides) 		5 / 11 GLY A 173
ILE A 175
THR A 139
LEU A 162
THR A 183
 None
 1.40A 3bf1C-3deaA:
undetectable
3bf1D-3deaA:
undetectable		 3bf1C-3deaA:
22.01
3bf1D-3deaA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3dea CUTINASE
(Colletotrichum
gloeosporioides) 		4 / 7 THR A 183
ILE A 175
THR A 139
GLY A 133
 None
 0.96A 4eq4A-3deaA:
undetectable		 4eq4A-3deaA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3dea CUTINASE
(Colletotrichum
gloeosporioides) 		4 / 7 THR A 183
ILE A 175
THR A 139
GLY A 133
 None
 0.93A 4eqlA-3deaA:
undetectable		 4eqlA-3deaA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3dea CUTINASE
(Colletotrichum
gloeosporioides) 		4 / 7 THR A 183
ILE A 175
THR A 139
GLY A 133
 None
 0.92A 4eqlB-3deaA:
undetectable		 4eqlB-3deaA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 3dea CUTINASE
(Colletotrichum
gloeosporioides) 		5 / 11 ALA A 211
VAL A  86
TYR A  51
GLY A  64
GLY A  88
 None
 1.16A 4xp4A-3deaA:
undetectable		 4xp4A-3deaA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3dea CUTINASE
(Colletotrichum
gloeosporioides) 		4 / 7 GLY A 138
GLY A 133
TYR A 207
ALA A  56
 None
None
None
HZH  A 401 (-3.2A)
 0.97A 5e26A-3deaA:
2.5
5e26B-3deaA:
2.2		 5e26A-3deaA:
18.90
5e26B-3deaA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3dea CUTINASE
(Colletotrichum
gloeosporioides) 		5 / 10 ILE A 175
PHE A 118
GLY A 134
GLY A 133
TYR A  51
 None
 1.29A 5lbtA-3deaA:
4.7
5lbtB-3deaA:
4.8		 5lbtA-3deaA:
23.94
5lbtB-3deaA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 3dea CUTINASE
(Colletotrichum
gloeosporioides) 		5 / 12 LEU A 149
SER A 132
VAL A  89
TYR A  93
THR A 106
 None
 1.37A 5v1tA-3deaA:
undetectable		 5v1tA-3deaA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 3dea CUTINASE
(Colletotrichum
gloeosporioides) 		5 / 12 GLY A 138
VAL A 141
ALA A 114
GLY A  88
TYR A  51
 None
 0.96A 5xv7A-3deaA:
undetectable		 5xv7A-3deaA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 3dea CUTINASE
(Colletotrichum
gloeosporioides) 		3 / 3 ALA A  74
VAL A 131
TYR A  51
 None
 0.51A 5zmqH-3deaA:
undetectable		 5zmqH-3deaA:
20.89