SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3deg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
3 / 3 ALA C 234
VAL C 259
TRP C 257
None
0.80A 1av2C-3degC:
undetectable
1av2D-3degC:
undetectable
1av2C-3degC:
5.43
1av2D-3degC:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
5 / 8 LEU C  20
GLY C  97
ILE C 180
VAL C 101
ILE C   9
None
1.06A 1d4yB-3degC:
undetectable
1d4yB-3degC:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
5 / 12 GLU C 356
LEU C 355
ILE C  52
LEU C 317
LEU C 314
None
1.06A 1errB-3degC:
undetectable
1errB-3degC:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 8 ALA C 119
ASP C 154
ILE C 153
ILE C 147
None
0.89A 1p7lD-3degC:
undetectable
1p7lD-3degC:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 8 ALA C 119
ASP C 154
ILE C 153
ILE C 147
None
0.90A 1p7lC-3degC:
undetectable
1p7lC-3degC:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
5 / 10 ALA C  56
ASP C  42
LEU C  41
ILE C  24
ILE C   9
None
1.09A 1rb3A-3degC:
undetectable
1rb3A-3degC:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
5 / 12 ALA C  56
ASP C  42
LEU C  41
ILE C  24
ILE C   9
None
1.06A 1re7A-3degC:
undetectable
1re7A-3degC:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 8 ALA C 119
ASP C 154
ILE C 153
ILE C 147
None
0.87A 1rg9B-3degC:
undetectable
1rg9B-3degC:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 8 ALA C 119
ASP C 154
ILE C 153
ILE C 147
None
0.90A 1rg9A-3degC:
undetectable
1rg9A-3degC:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 8 ALA C 119
ASP C 154
ILE C 153
ILE C 147
None
0.88A 1rg9D-3degC:
undetectable
1rg9D-3degC:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 8 ALA C 119
ASP C 154
ILE C 153
ILE C 147
None
0.89A 1rg9C-3degC:
undetectable
1rg9C-3degC:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 6 LYS C 283
ALA C 284
SER C 227
THR C 273
None
1.20A 1tyrA-3degC:
undetectable
1tyrA-3degC:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 6 LEU C 237
LEU C 258
SER C 208
SER C 198
None
0.78A 1tz8C-3degC:
undetectable
1tz8D-3degC:
undetectable
1tz8C-3degC:
13.74
1tz8D-3degC:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
3 / 3 ALA C 234
VAL C 259
TRP C 257
None
0.83A 1w5uC-3degC:
undetectable
1w5uD-3degC:
undetectable
1w5uC-3degC:
5.43
1w5uD-3degC:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
5 / 12 GLY C 427
CYH C 422
LEU C 458
LEU C 441
MET C 408
None
1.45A 1zgyA-3degC:
undetectable
1zgyA-3degC:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 7 LEU C  73
PHE C  75
PHE C   7
LEU C 176
None
1.00A 2eimP-3degC:
undetectable
2eimW-3degC:
undetectable
2eimP-3degC:
17.43
2eimW-3degC:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 7 THR C  53
SER C  18
SER C  21
LEU C 209
None
1.00A 2hdnE-3degC:
undetectable
2hdnF-3degC:
9.1
2hdnH-3degC:
9.1
2hdnE-3degC:
4.64
2hdnF-3degC:
23.60
2hdnH-3degC:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 7 SER C  21
LEU C 209
THR C  53
SER C  18
None
1.04A 2hdnF-3degC:
9.1
2hdnG-3degC:
undetectable
2hdnH-3degC:
9.1
2hdnF-3degC:
23.60
2hdnG-3degC:
4.64
2hdnH-3degC:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
3 / 3 TRP C 257
ALA C 234
VAL C 259
None
0.78A 2izqA-3degC:
undetectable
2izqB-3degC:
undetectable
2izqA-3degC:
5.43
2izqB-3degC:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 6 SER C 331
LEU C 334
SER C 332
ASP C 493
None
1.01A 2j2pE-3degC:
undetectable
2j2pF-3degC:
undetectable
2j2pE-3degC:
16.45
2j2pF-3degC:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
5 / 11 HIS C 266
SER C 227
GLY C 271
ILE C 195
VAL C 206
None
1.13A 2uxpB-3degC:
undetectable
2uxpB-3degC:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 5 ALA C 193
GLY C 253
CYH C 252
LYS C 251
None
1.38A 2ylgA-3degC:
undetectable
2ylgA-3degC:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 6 LEU C  73
PHE C  75
PHE C   7
LEU C 176
None
1.02A 3abkP-3degC:
undetectable
3abkW-3degC:
undetectable
3abkP-3degC:
17.43
3abkW-3degC:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 7 LEU C  73
PHE C  75
PHE C   7
LEU C 176
None
0.97A 3ag2C-3degC:
undetectable
3ag2C-3degC:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 7 LEU C  73
PHE C  75
PHE C   7
LEU C 176
None
0.98A 3ag2P-3degC:
undetectable
3ag2W-3degC:
undetectable
3ag2P-3degC:
17.43
3ag2W-3degC:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 7 LEU C  73
PHE C  75
PHE C   7
LEU C 176
None
1.03A 3asnP-3degC:
undetectable
3asnW-3degC:
undetectable
3asnP-3degC:
17.43
3asnW-3degC:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 7 LEU C  73
PHE C  75
PHE C   7
LEU C 176
None
1.01A 3asoP-3degC:
undetectable
3asoW-3degC:
undetectable
3asoP-3degC:
17.43
3asoW-3degC:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
3 / 3 TYR C 414
GLU C 109
ASP C  14
None
0.77A 3bxoA-3degC:
undetectable
3bxoA-3degC:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
3 / 3 TYR C 414
GLU C 109
ASP C  14
None
0.69A 3bxoB-3degC:
undetectable
3bxoB-3degC:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
5 / 10 TYR C  63
ILE C  24
ILE C  27
VAL C 159
LEU C  73
None
1.01A 3elzB-3degC:
undetectable
3elzB-3degC:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
5 / 10 TYR C  63
ILE C  24
ILE C  27
VAL C 159
LEU C  73
None
1.13A 3elzC-3degC:
undetectable
3elzC-3degC:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
3 / 3 ALA C 234
VAL C 259
TRP C 257
None
0.76A 3l8lA-3degC:
undetectable
3l8lB-3degC:
undetectable
3l8lA-3degC:
5.43
3l8lB-3degC:
4.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP6_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
5 / 12 PHE C 455
THR C 461
SER C 462
MET C 408
VAL C  82
None
1.25A 3sp6A-3degC:
undetectable
3sp6A-3degC:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 6 LEU C  73
PHE C  75
PHE C   7
LEU C 176
None
0.96A 3wg7C-3degC:
undetectable
3wg7J-3degC:
undetectable
3wg7C-3degC:
17.43
3wg7J-3degC:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 6 LEU C 299
PHE C 338
PHE C 310
LEU C 355
None
1.08A 3wg7C-3degC:
undetectable
3wg7J-3degC:
undetectable
3wg7C-3degC:
17.43
3wg7J-3degC:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 6 LEU C  73
PHE C  75
PHE C   7
LEU C 176
None
1.01A 3wg7P-3degC:
undetectable
3wg7W-3degC:
undetectable
3wg7P-3degC:
17.43
3wg7W-3degC:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 7 LEU C  73
PHE C  75
PHE C   7
LEU C 176
None
0.98A 3x2qP-3degC:
undetectable
3x2qW-3degC:
undetectable
3x2qP-3degC:
17.43
3x2qW-3degC:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 8 ALA C 119
ASP C 154
ILE C 153
ILE C 147
None
0.91A 4kttD-3degC:
undetectable
4kttD-3degC:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 8 ILE C 519
LYS C 516
ILE C 526
ALA C 527
None
0.98A 4ou1A-3degC:
undetectable
4ou1A-3degC:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 6 LEU C 237
THR C  60
LEU C 258
SER C 208
None
0.66A 4pwjA-3degC:
undetectable
4pwjA-3degC:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 7 LEU C 237
THR C  60
LEU C 258
SER C 208
None
0.76A 4pwjB-3degC:
undetectable
4pwjB-3degC:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 7 VAL C 151
ILE C  10
ALA C 119
ILE C   9
None
0.73A 4uxqA-3degC:
undetectable
4uxqA-3degC:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
3 / 4 ARG C 507
GLY C 508
GLU C 510
None
0.68A 4z2dB-3degC:
undetectable
4z2dC-3degC:
2.3
4z2dB-3degC:
24.27
4z2dC-3degC:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 7 LEU C  73
PHE C  75
PHE C   7
LEU C 176
None
0.95A 5b1aC-3degC:
undetectable
5b1aJ-3degC:
undetectable
5b1aC-3degC:
17.43
5b1aJ-3degC:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 7 LEU C  73
PHE C  75
PHE C   7
LEU C 176
None
0.90A 5b1aP-3degC:
undetectable
5b1aW-3degC:
undetectable
5b1aP-3degC:
17.43
5b1aW-3degC:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 7 LEU C  73
PHE C  75
PHE C   7
LEU C 176
None
0.91A 5b1bP-3degC:
undetectable
5b1bW-3degC:
undetectable
5b1bP-3degC:
17.43
5b1bW-3degC:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 7 LEU C  73
PHE C  75
PHE C   7
LEU C 176
None
0.93A 5b3sC-3degC:
undetectable
5b3sJ-3degC:
undetectable
5b3sC-3degC:
17.43
5b3sJ-3degC:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 7 LEU C  73
PHE C  75
PHE C   7
LEU C 176
None
0.93A 5b3sP-3degC:
undetectable
5b3sP-3degC:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 7 LEU C 237
THR C  60
LEU C 258
SER C 208
None
0.76A 5bojB-3degC:
undetectable
5bojB-3degC:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
5 / 12 ILE C  76
SER C  58
VAL C 169
CYH C 161
LEU C  20
None
1.22A 5ergB-3degC:
undetectable
5ergB-3degC:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 5 ALA C 193
GLY C 253
CYH C 252
LYS C 251
None
1.43A 5jliA-3degC:
undetectable
5jliA-3degC:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 5 ALA C 193
GLY C 253
CYH C 252
LYS C 251
None
1.49A 5jt4A-3degC:
undetectable
5jt4A-3degC:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
5 / 10 ILE C 532
ILE C 537
VAL C 481
THR C 499
ASN C 503
None
A  A  67 ( 4.8A)
None
None
None
1.20A 5lg3F-3degC:
undetectable
5lg3F-3degC:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
5 / 10 ILE C 532
ILE C 537
VAL C 481
THR C 499
ASN C 503
None
A  A  67 ( 4.8A)
None
None
None
1.21A 5lg3G-3degC:
undetectable
5lg3G-3degC:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
5 / 10 ILE C 532
ILE C 537
VAL C 481
THR C 499
ASN C 503
None
A  A  67 ( 4.8A)
None
None
None
1.20A 5lg3H-3degC:
undetectable
5lg3H-3degC:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
5 / 12 ILE C 532
ILE C 537
VAL C 481
THR C 499
ASN C 503
None
A  A  67 ( 4.8A)
None
None
None
1.20A 5lg3J-3degC:
undetectable
5lg3J-3degC:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
5 / 10 ALA C 193
LEU C 194
GLY C 271
ILE C 180
LEU C 176
None
1.20A 5oy01-3degC:
undetectable
5oy07-3degC:
undetectable
5oy01-3degC:
10.16
5oy07-3degC:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 8 ALA C 119
ASP C 154
ILE C 153
ILE C 147
None
0.89A 5t8sA-3degC:
undetectable
5t8sA-3degC:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 9 TYR C 307
ILE C 351
ILE C 350
LEU C 346
None
0.81A 5vkqB-3degC:
undetectable
5vkqC-3degC:
undetectable
5vkqB-3degC:
16.09
5vkqC-3degC:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 6 LEU C 299
PHE C 338
PHE C 310
LEU C 355
None
1.09A 5x19P-3degC:
undetectable
5x19P-3degC:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 5 LEU C  73
PHE C  75
PHE C   7
LEU C 176
None
1.06A 5x1bP-3degC:
undetectable
5x1bP-3degC:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 5 LEU C 299
PHE C 338
PHE C 310
LEU C 355
None
1.09A 5x1bP-3degC:
undetectable
5x1bP-3degC:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 7 LEU C  73
PHE C  75
PHE C   7
LEU C 176
None
1.04A 5x1fP-3degC:
undetectable
5x1fW-3degC:
undetectable
5x1fP-3degC:
17.43
5x1fW-3degC:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 7 LEU C  73
PHE C  75
PHE C   7
LEU C 176
None
0.98A 5zcqC-3degC:
undetectable
5zcqJ-3degC:
undetectable
5zcqC-3degC:
17.43
5zcqJ-3degC:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
4 / 7 LEU C  73
PHE C  75
PHE C   7
LEU C 176
None
0.94A 5zcqP-3degC:
undetectable
5zcqW-3degC:
undetectable
5zcqP-3degC:
17.43
5zcqW-3degC:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli)
5 / 12 ILE C 195
ALA C 193
GLN C 192
ILE C 262
LEU C 258
None
1.05A 6a60D-3degC:
undetectable
6a60D-3degC:
9.91