SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dew'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 3dew TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Geobacter
sulfurreducens) 		5 / 10 LEU A 128
VAL A 124
ILE A  70
LEU A  85
VAL A 158
 None
ACY  A 209 ( 4.7A)
None
None
None
 1.16A 1cqpA-3dewA:
undetectable
1cqpB-3dewA:
undetectable		 1cqpA-3dewA:
21.33
1cqpB-3dewA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3dew TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Geobacter
sulfurreducens) 		5 / 11 GLY A  48
ALA A  32
HIS A  45
ILE A  28
ALA A  37
 None
 1.17A 1gtnM-3dewA:
undetectable
1gtnN-3dewA:
undetectable		 1gtnM-3dewA:
16.59
1gtnN-3dewA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3dew TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Geobacter
sulfurreducens) 		5 / 10 GLY A  48
ALA A  32
HIS A  45
ILE A  28
ALA A  37
 None
 1.17A 1gtnU-3dewA:
undetectable
1gtnV-3dewA:
undetectable		 1gtnU-3dewA:
16.59
1gtnV-3dewA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 3dew TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Geobacter
sulfurreducens) 		4 / 8 SER A 150
THR A 137
MET A 136
LEU A 145
 None
 1.08A 1lhvA-3dewA:
undetectable		 1lhvA-3dewA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dew TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Geobacter
sulfurreducens) 		5 / 10 GLY A  48
ALA A  32
HIS A  45
ILE A  28
ALA A  37
 None
 1.18A 1utdT-3dewA:
undetectable
1utdU-3dewA:
undetectable		 1utdT-3dewA:
16.59
1utdU-3dewA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 3dew TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Geobacter
sulfurreducens) 		5 / 12 PHE A  61
LEU A  98
ALA A 120
PRO A 119
VAL A 124
 None
None
None
None
ACY  A 209 ( 4.7A)
 1.14A 3cwkA-3dewA:
undetectable		 3cwkA-3dewA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 3dew TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Geobacter
sulfurreducens) 		4 / 6 LEU A 128
ILE A 125
ASN A 159
VAL A 158
 None
None
ACY  A 209 (-3.4A)
None
 0.86A 4a9kA-3dewA:
undetectable		 4a9kA-3dewA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 3dew TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Geobacter
sulfurreducens) 		4 / 5 LEU A  99
LEU A  98
THR A  88
TRP A  87
 None
None
ACY  A 209 ( 3.8A)
None
 1.25A 4do3A-3dewA:
undetectable		 4do3A-3dewA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3dew TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Geobacter
sulfurreducens) 		3 / 3 TYR A  84
HIS A  92
ARG A  91
 ACY  A 209 (-4.6A)
None
ACY  A 209 (-3.7A)
 1.17A 4htfA-3dewA:
undetectable		 4htfA-3dewA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 3dew TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Geobacter
sulfurreducens) 		4 / 7 LEU A  57
VAL A  56
TYR A 102
GLU A 105
 None
None
ACY  A 209 (-4.2A)
None
 0.97A 4lb2A-3dewA:
3.9		 4lb2A-3dewA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 3dew TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Geobacter
sulfurreducens) 		3 / 3 ARG A 143
ASP A 144
ARG A 142
 EDO  A 207 (-3.9A)
None
None
 0.68A 4wq4B-3dewA:
undetectable		 4wq4B-3dewA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dew TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Geobacter
sulfurreducens) 		5 / 10 GLY A  48
ALA A  32
HIS A  45
ILE A  28
ALA A  37
 None
 1.17A 5eeuO-3dewA:
undetectable
5eeuP-3dewA:
undetectable		 5eeuO-3dewA:
16.59
5eeuP-3dewA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dew TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Geobacter
sulfurreducens) 		5 / 10 GLY A  48
ALA A  32
HIS A  45
ILE A  28
ALA A  37
 None
 1.18A 5eevO-3dewA:
undetectable
5eevP-3dewA:
undetectable		 5eevO-3dewA:
16.59
5eevP-3dewA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dew TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Geobacter
sulfurreducens) 		5 / 10 GLY A  48
ALA A  32
HIS A  45
ILE A  28
ALA A  37
 None
 1.18A 5eewO-3dewA:
undetectable
5eewP-3dewA:
undetectable		 5eewO-3dewA:
16.59
5eewP-3dewA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dew TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Geobacter
sulfurreducens) 		5 / 10 GLY A  48
ALA A  32
HIS A  45
ILE A  28
ALA A  37
 None
 1.18A 5eexO-3dewA:
undetectable
5eexP-3dewA:
undetectable		 5eexO-3dewA:
16.59
5eexP-3dewA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dew TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Geobacter
sulfurreducens) 		5 / 10 GLY A  48
ALA A  32
HIS A  45
ILE A  28
ALA A  37
 None
 1.18A 5eeyO-3dewA:
undetectable
5eeyP-3dewA:
undetectable		 5eeyO-3dewA:
16.59
5eeyP-3dewA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dew TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Geobacter
sulfurreducens) 		5 / 10 GLY A  48
ALA A  32
HIS A  45
ILE A  28
ALA A  37
 None
 1.18A 5eezO-3dewA:
undetectable
5eezP-3dewA:
undetectable		 5eezO-3dewA:
16.59
5eezP-3dewA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 3dew TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Geobacter
sulfurreducens) 		5 / 12 LEU A  85
ALA A  83
VAL A  80
ILE A 121
ALA A 155
 None
None
None
None
ACY  A 209 ( 4.0A)
 1.12A 5n5dB-3dewA:
undetectable		 5n5dB-3dewA:
24.48