SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dez'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 3dez OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Streptococcus
mutans) 		4 / 5 ILE A 120
LEU A 170
ALA A 150
GLU A 122
 None
 1.27A 1xvaA-3dezA:
3.0
1xvaB-3dezA:
2.9		 1xvaA-3dezA:
22.93
1xvaB-3dezA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 3dez OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Streptococcus
mutans) 		3 / 3 THR A  48
PRO A  46
THR A  50
 None
 0.69A 209dC-3dezA:
undetectable		 209dC-3dezA:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3dez OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Streptococcus
mutans) 		4 / 8 LEU A 197
LEU A 194
LYS A 184
ALA A 183
 None
 1.06A 2wekA-3dezA:
3.7		 2wekA-3dezA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 3dez OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Streptococcus
mutans) 		3 / 3 LEU A 194
ARG A   9
ASN A 175
 None
 0.64A 3qxvD-3dezA:
undetectable		 3qxvD-3dezA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 3dez OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Streptococcus
mutans) 		4 / 6 LEU A 124
ALA A 150
SER A 174
THR A 172
 None
 1.25A 4d7bB-3dezA:
undetectable		 4d7bB-3dezA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3dez OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Streptococcus
mutans) 		4 / 6 LYS A  20
GLU A  22
GLY A 193
ASP A 190
 None
 1.04A 5a06D-3dezA:
undetectable		 5a06D-3dezA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 3dez OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Streptococcus
mutans) 		5 / 9 LYS A 184
ASP A 192
LEU A 196
LEU A 197
LEU A  19
 None
 1.10A 5dqfA-3dezA:
undetectable		 5dqfA-3dezA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 3dez OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Streptococcus
mutans) 		5 / 12 ALA A  74
ARG A  40
GLY A  77
GLY A  81
ILE A  83
 None
SO4  A 211 (-4.1A)
None
None
None
 1.14A 5ul4A-3dezA:
2.7		 5ul4A-3dezA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 3dez OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Streptococcus
mutans) 		3 / 3 VAL A  69
ALA A  93
GLN A 116
 None
 0.66A 6gb9A-3dezA:
undetectable		 6gb9A-3dezA:
18.83