SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dff'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 3dff TEICOPLANIN
PSEUDOAGLYCONE
DEACETYLASES ORF2
(Actinoplanes
teichomyceticus) 		5 / 12 LEU A  10
LEU A  28
LEU A  86
GLN A 221
MET A 218
 None
 1.39A 1sqnA-3dffA:
undetectable		 1sqnA-3dffA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 3dff TEICOPLANIN
PSEUDOAGLYCONE
DEACETYLASES ORF2
(Actinoplanes
teichomyceticus) 		4 / 6 TYR A 229
SER A  14
ALA A  20
THR A  42
 None
 0.89A 1yvpB-3dffA:
2.0		 1yvpB-3dffA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3dff TEICOPLANIN
PSEUDOAGLYCONE
DEACETYLASES ORF2
(Actinoplanes
teichomyceticus) 		4 / 4 PRO A 162
ASP A 129
ASP A 127
ASP A 169
 PG4  A 400 ( 4.7A)
None
None
None
 1.49A 2nyuA-3dffA:
4.3		 2nyuA-3dffA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 3dff TEICOPLANIN
PSEUDOAGLYCONE
DEACETYLASES ORF2
(Actinoplanes
teichomyceticus) 		5 / 12 LEU A  10
LEU A  28
LEU A  86
GLN A 221
MET A 218
 None
 1.41A 2w8yB-3dffA:
undetectable		 2w8yB-3dffA:
20.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3dff TEICOPLANIN
PSEUDOAGLYCONE
DEACETYLASES ORF2
(Actinoplanes
teichomyceticus) 		8 / 8 HIS A  16
TRP A  63
ARG A  75
ASP A  97
SER A  98
ILE A  99
HIS A 161
ASP A 163
 ZN  A 274 ( 3.2A)
None
PG4  A 400 (-2.7A)
PG4  A 400 (-3.1A)
PG4  A 400 (-3.0A)
PG4  A 400 (-4.6A)
PG4  A 400 (-4.2A)
None
 0.33A 2xadA-3dffA:
43.0		 2xadA-3dffA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3dff TEICOPLANIN
PSEUDOAGLYCONE
DEACETYLASES ORF2
(Actinoplanes
teichomyceticus) 		8 / 8 HIS A  16
TRP A  63
ARG A  75
ASP A  97
SER A  98
ILE A  99
HIS A 161
ASP A 163
 ZN  A 274 ( 3.2A)
None
PG4  A 400 (-2.7A)
PG4  A 400 (-3.1A)
PG4  A 400 (-3.0A)
PG4  A 400 (-4.6A)
PG4  A 400 (-4.2A)
None
 0.33A 2xadB-3dffA:
42.6		 2xadB-3dffA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3dff TEICOPLANIN
PSEUDOAGLYCONE
DEACETYLASES ORF2
(Actinoplanes
teichomyceticus) 		8 / 8 HIS A  16
TRP A  63
ARG A  75
ASP A  97
SER A  98
ILE A  99
HIS A 161
ASP A 163
 ZN  A 274 ( 3.2A)
None
PG4  A 400 (-2.7A)
PG4  A 400 (-3.1A)
PG4  A 400 (-3.0A)
PG4  A 400 (-4.6A)
PG4  A 400 (-4.2A)
None
 0.32A 2xadC-3dffA:
42.4		 2xadC-3dffA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3dff TEICOPLANIN
PSEUDOAGLYCONE
DEACETYLASES ORF2
(Actinoplanes
teichomyceticus) 		8 / 8 HIS A  16
TRP A  63
ARG A  75
ASP A  97
SER A  98
ILE A  99
HIS A 161
ASP A 163
 ZN  A 274 ( 3.2A)
None
PG4  A 400 (-2.7A)
PG4  A 400 (-3.1A)
PG4  A 400 (-3.0A)
PG4  A 400 (-4.6A)
PG4  A 400 (-4.2A)
None
 0.32A 2xadD-3dffA:
42.6		 2xadD-3dffA:
99.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 3dff TEICOPLANIN
PSEUDOAGLYCONE
DEACETYLASES ORF2
(Actinoplanes
teichomyceticus) 		5 / 12 LEU A  10
LEU A  28
LEU A  86
GLN A 221
MET A 218
 None
 1.37A 3d90A-3dffA:
undetectable		 3d90A-3dffA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 3dff TEICOPLANIN
PSEUDOAGLYCONE
DEACETYLASES ORF2
(Actinoplanes
teichomyceticus) 		5 / 12 LEU A  10
GLY A  27
GLY A  25
SER A 220
ALA A  32
 None
 1.19A 3i5uB-3dffA:
5.7		 3i5uB-3dffA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 3dff TEICOPLANIN
PSEUDOAGLYCONE
DEACETYLASES ORF2
(Actinoplanes
teichomyceticus) 		5 / 10 LEU A 151
ALA A  12
VAL A  38
GLY A  25
LEU A  10
 None
 0.82A 3ogpB-3dffA:
undetectable		 3ogpB-3dffA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 3dff TEICOPLANIN
PSEUDOAGLYCONE
DEACETYLASES ORF2
(Actinoplanes
teichomyceticus) 		5 / 10 LEU A 151
ALA A  12
VAL A  38
GLY A  25
LEU A  10
 None
 0.84A 3ogqA-3dffA:
undetectable		 3ogqA-3dffA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3dff TEICOPLANIN
PSEUDOAGLYCONE
DEACETYLASES ORF2
(Actinoplanes
teichomyceticus) 		5 / 12 ILE A  13
THR A 154
THR A 264
GLU A 262
SER A  23
 None
 1.35A 6bzoC-3dffA:
undetectable		 6bzoC-3dffA:
12.66