SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dfi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		5 / 11 LEU A 148
ALA A  12
VAL A  38
GLY A  25
ILE A  10
 None
 0.81A 1c6yA-3dfiA:
undetectable		 1c6yA-3dfiA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		4 / 7 LEU A 150
ALA A  12
VAL A  40
VAL A  38
 None
 0.61A 1epbA-3dfiA:
undetectable		 1epbA-3dfiA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		3 / 3 LEU A 197
PRO A 198
LEU A 201
 None
 0.45A 1hrkA-3dfiA:
3.8		 1hrkA-3dfiA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		5 / 10 LEU A 148
ALA A  12
VAL A  38
GLY A  25
ILE A  10
 None
 0.81A 1hsgA-3dfiA:
undetectable		 1hsgA-3dfiA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_2
(PROTEASE RETROPEPSIN)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		5 / 11 LEU A 148
ALA A  12
VAL A  38
GLY A  25
ILE A  10
 None
 0.96A 1t3rB-3dfiA:
undetectable		 1t3rB-3dfiA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		4 / 6 TYR A 226
SER A  14
ALA A  20
THR A  42
 None
 0.85A 1yvpB-3dfiA:
undetectable		 1yvpB-3dfiA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		4 / 6 GLU A 138
ASP A 136
PHE A  95
ARG A  94
 None
 1.22A 2a3bB-3dfiA:
undetectable		 2a3bB-3dfiA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		5 / 12 LEU A 148
ALA A  12
VAL A  38
GLY A  25
ILE A  10
 None
 0.79A 2avvD-3dfiA:
undetectable		 2avvD-3dfiA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		4 / 7 TYR A 226
SER A  14
ALA A  20
THR A  42
 None
 0.91A 2i91A-3dfiA:
undetectable		 2i91A-3dfiA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		4 / 7 TYR A 226
SER A  14
ALA A  20
THR A  42
 None
 0.91A 2i91B-3dfiA:
2.2		 2i91B-3dfiA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		5 / 12 LEU A 148
ALA A  12
VAL A  38
GLY A  25
ILE A  10
 None
 0.92A 2ienA-3dfiA:
undetectable		 2ienA-3dfiA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		5 / 9 LEU A 148
ALA A  12
VAL A  38
GLY A  25
ILE A  10
 None
 0.91A 2o4pB-3dfiA:
undetectable		 2o4pB-3dfiA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		3 / 3 LEU A 197
PRO A 198
LEU A 201
 None
 0.46A 2qd5B-3dfiA:
2.8		 2qd5B-3dfiA:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		7 / 8 HIS A  16
TRP A  63
ARG A  75
ASP A  97
ILE A  99
HIS A 158
ASP A 160
 ZN  A 300 (-3.2A)
None
None
None
None
None
None
 0.36A 2xadA-3dfiA:
35.6		 2xadA-3dfiA:
59.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		7 / 8 HIS A  16
TRP A  63
ARG A  75
ASP A  97
ILE A  99
HIS A 158
ASP A 160
 ZN  A 300 (-3.2A)
None
None
None
None
None
None
 0.34A 2xadB-3dfiA:
35.6		 2xadB-3dfiA:
59.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		7 / 8 HIS A  16
TRP A  63
ARG A  75
ASP A  97
ILE A  99
HIS A 158
ASP A 160
 ZN  A 300 (-3.2A)
None
None
None
None
None
None
 0.39A 2xadC-3dfiA:
35.2		 2xadC-3dfiA:
59.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		7 / 8 HIS A  16
TRP A  63
ARG A  75
ASP A  97
ILE A  99
HIS A 158
ASP A 160
 ZN  A 300 (-3.2A)
None
None
None
None
None
None
 0.41A 2xadD-3dfiA:
35.5		 2xadD-3dfiA:
59.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		5 / 10 LEU A 148
ALA A  12
VAL A  38
GLY A  25
ILE A  10
 None
 0.92A 3ekpB-3dfiA:
undetectable		 3ekpB-3dfiA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		5 / 10 LEU A 148
ALA A  12
VAL A  38
GLY A  25
ILE A  10
 None
 0.89A 3ekpC-3dfiA:
undetectable		 3ekpC-3dfiA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		5 / 10 LEU A 148
ALA A  12
VAL A  38
GLY A  25
ILE A  10
 None
 0.89A 3ekpD-3dfiA:
undetectable		 3ekpD-3dfiA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		5 / 11 LEU A 148
ALA A  12
VAL A  38
GLY A  25
ILE A  10
 None
 0.89A 3ektC-3dfiA:
undetectable		 3ektC-3dfiA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		5 / 10 LEU A 148
ALA A  12
VAL A  38
GLY A  25
ILE A  10
 None
 0.92A 3em3B-3dfiA:
undetectable		 3em3B-3dfiA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		5 / 9 VAL A  24
SER A  23
ILE A  13
ALA A  12
ALA A  88
 None
 1.17A 3mdtA-3dfiA:
undetectable		 3mdtA-3dfiA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		4 / 6 GLN A 229
HIS A 158
HIS A 161
ASP A  18
 None
None
ZN  A 300 (-3.4A)
ZN  A 300 ( 4.8A)
 1.14A 3nvcA-3dfiA:
undetectable		 3nvcA-3dfiA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		5 / 9 LEU A 148
ALA A  12
VAL A  38
GLY A  25
ILE A  10
 None
 0.93A 3oxvC-3dfiA:
undetectable		 3oxvC-3dfiA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		5 / 10 LEU A 148
ALA A  12
VAL A  38
GLY A  25
ILE A  10
 None
 0.92A 3oxwB-3dfiA:
undetectable		 3oxwB-3dfiA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		5 / 10 LEU A 148
ALA A  12
VAL A  38
GLY A  25
ILE A  10
 None
 0.95A 3oxwD-3dfiA:
undetectable		 3oxwD-3dfiA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_1
(HIV-1 PROTEASE)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		5 / 11 LEU A 148
ALA A  12
VAL A  38
GLY A  25
ILE A  10
 None
 0.94A 3oy4A-3dfiA:
undetectable		 3oy4A-3dfiA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		3 / 3 LEU A 197
PRO A 198
LEU A 201
 None
 0.38A 3w1wB-3dfiA:
1.4		 3w1wB-3dfiA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		4 / 7 LEU A 244
TYR A 190
TYR A 187
LEU A  22
 None
 1.04A 4b3qA-3dfiA:
undetectable		 4b3qA-3dfiA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		5 / 11 LEU A 148
ALA A  12
VAL A  38
GLY A  25
ILE A  10
 None
 0.97A 4dqeA-3dfiA:
undetectable		 4dqeA-3dfiA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		5 / 11 LEU A 148
ALA A  12
VAL A  38
GLY A  25
ILE A  10
 None
 0.96A 4dqhA-3dfiA:
undetectable		 4dqhA-3dfiA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_1
(PROTEASE)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		5 / 11 LEU A 148
ALA A  12
VAL A  38
GLY A  25
ILE A  10
 None
 0.96A 4njtC-3dfiA:
undetectable		 4njtC-3dfiA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		5 / 10 LEU A 148
ALA A  12
VAL A  38
GLY A  25
ILE A  10
 None
 0.89A 4njuB-3dfiA:
undetectable		 4njuB-3dfiA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		5 / 10 LEU A 148
ALA A  12
VAL A  38
GLY A  25
ILE A  10
 None
 0.88A 4njuD-3dfiA:
undetectable		 4njuD-3dfiA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		5 / 11 LEU A 148
ALA A  12
VAL A  38
GLY A  25
ILE A  10
 None
 0.83A 4qgiB-3dfiA:
undetectable		 4qgiB-3dfiA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21
(Actinoplanes
teichomyceticus) 		5 / 12 ILE A  13
THR A 151
THR A 261
GLU A 259
SER A  23
 None
 1.40A 6bzoC-3dfiA:
undetectable		 6bzoC-3dfiA:
13.67