SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dfr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		10 / 12 ALA A   6
ASP A  26
LEU A  27
PHE A  30
THR A  45
SER A  48
PHE A  49
LEU A  54
ARG A  57
ALA A  97
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 3.8A)
 0.80A 1ao8A-3dfrA:
26.6		 1ao8A-3dfrA:
98.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		11 / 12 LEU A   4
ALA A   6
ASP A  26
LEU A  27
PHE A  30
THR A  45
SER A  48
PHE A  49
LEU A  54
ALA A  97
THR A 116
 MTX  A 164 ( 4.1A)
MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 3.8A)
MTX  A 164 ( 4.3A)
 0.76A 1ao8A-3dfrA:
26.6		 1ao8A-3dfrA:
98.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AO8_A_MTXA170_2
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		4 / 4 TRP A   5
LEU A  19
ARG A  31
THR A  34
 None
MTX  A 164 (-4.5A)
None
None
 0.95A 1ao8A-3dfrA:
26.6		 1ao8A-3dfrA:
98.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		9 / 12 ALA A   6
HIS A  18
ASP A  26
PHE A  30
THR A  45
PHE A  49
LEU A  54
ALA A  97
THR A 116
 MTX  A 164 (-3.8A)
None
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 3.8A)
MTX  A 164 ( 4.3A)
 0.92A 1bzfA-3dfrA:
25.6		 1bzfA-3dfrA:
98.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		9 / 12 LEU A   4
ALA A   6
ASP A  26
LEU A  27
PHE A  30
THR A  45
PHE A  49
ALA A  97
THR A 116
 MTX  A 164 ( 4.1A)
MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 3.8A)
MTX  A 164 ( 4.3A)
 0.82A 1bzfA-3dfrA:
25.6		 1bzfA-3dfrA:
98.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		9 / 12 LEU A   4
ALA A   6
HIS A  18
ASP A  26
PHE A  30
THR A  45
PHE A  49
ALA A  97
THR A 116
 MTX  A 164 ( 4.1A)
MTX  A 164 (-3.8A)
None
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 3.8A)
MTX  A 164 ( 4.3A)
 0.92A 1bzfA-3dfrA:
25.6		 1bzfA-3dfrA:
98.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		9 / 12 LEU A   4
ALA A   6
HIS A  18
LEU A  19
ASP A  26
PHE A  30
PHE A  49
ALA A  97
THR A 116
 MTX  A 164 ( 4.1A)
MTX  A 164 (-3.8A)
None
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 3.8A)
MTX  A 164 ( 4.3A)
 1.00A 1bzfA-3dfrA:
25.6		 1bzfA-3dfrA:
98.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		9 / 12 LEU A   4
ALA A   6
LEU A  19
ASP A  26
LEU A  27
PHE A  30
PHE A  49
ALA A  97
THR A 116
 MTX  A 164 ( 4.1A)
MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 3.8A)
MTX  A 164 ( 4.3A)
 0.94A 1bzfA-3dfrA:
25.6		 1bzfA-3dfrA:
98.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  19
PHE A  30
THR A  45
PRO A  50
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.6A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.79A 1cd2A-3dfrA:
20.5		 1cd2A-3dfrA:
27.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
ASP A  26
ARG A  31
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
None
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.85A 1d1gA-3dfrA:
19.1		 1d1gA-3dfrA:
30.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
ASP A  26
ARG A  31
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
None
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.76A 1d1gB-3dfrA:
19.2		 1d1gB-3dfrA:
30.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
ASP A  26
LEU A  27
THR A  45
LEU A  54
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
 0.70A 1ddrA-3dfrA:
22.4		 1ddrA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
ASP A  26
LEU A  27
THR A  45
SER A  48
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
NDP  A 163 (-3.4A)
MTX  A 164 (-3.5A)
 0.84A 1ddrA-3dfrA:
22.4		 1ddrA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
ASP A  26
LEU A  27
PHE A  30
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.54A 1ddrB-3dfrA:
22.7		 1ddrB-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
ASP A  26
LEU A  27
THR A  45
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.56A 1ddsA-3dfrA:
22.7		 1ddsA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
ASP A  26
LEU A  27
SER A  48
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.75A 1ddsB-3dfrA:
23.1		 1ddsB-3dfrA:
29.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
ASP A  26
PRO A  50
LEU A  54
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.6A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
 0.67A 1df7A-3dfrA:
22.5		 1df7A-3dfrA:
34.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		3 / 3 TRP A   5
ARG A  31
THR A 116
 None
None
MTX  A 164 ( 4.3A)
 0.49A 1df7A-3dfrA:
22.5		 1df7A-3dfrA:
34.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 11 TRP A   5
ALA A   6
ASP A  26
PHE A  30
PRO A  50
 None
MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.6A)
 0.88A 1dg5A-3dfrA:
22.1		 1dg5A-3dfrA:
34.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 11 TRP A   5
ALA A   6
ASP A  26
SER A  48
PRO A  50
 None
MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.6A)
 0.65A 1dg5A-3dfrA:
22.1		 1dg5A-3dfrA:
34.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
PHE A  30
THR A  45
PRO A  50
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.6A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.71A 1dhfA-3dfrA:
21.3		 1dhfA-3dfrA:
31.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
PHE A  30
THR A  45
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.61A 1dhfB-3dfrA:
21.4		 1dhfB-3dfrA:
31.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
LEU A  27
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.69A 1dhiA-3dfrA:
22.8		 1dhiA-3dfrA:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 11 ALA A   6
LEU A  27
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.68A 1dhiB-3dfrA:
23.2		 1dhiB-3dfrA:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
LEU A  27
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.67A 1dhjA-3dfrA:
23.0		 1dhjA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  27
LEU A  54
PRO A  55
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
None
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.84A 1dhjB-3dfrA:
23.3		 1dhjB-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
LEU A  27
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.66A 1draB-3dfrA:
23.3		 1draB-3dfrA:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
LEU A  27
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.71A 1drbA-3dfrA:
23.0		 1drbA-3dfrA:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  27
PHE A  30
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.69A 1drbB-3dfrA:
23.2		 1drbB-3dfrA:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
ASP A  26
LEU A  27
PHE A  30
SER A  48
LEU A  54
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
 0.65A 1dreA-3dfrA:
24.0		 1dreA-3dfrA:
29.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
LEU A  19
PHE A  30
SER A  48
LEU A  54
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.4A)
 0.75A 1drfA-3dfrA:
21.2		 1drfA-3dfrA:
31.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
LEU A  19
PHE A  30
SER A  48
PRO A  50
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.6A)
 0.72A 1drfA-3dfrA:
21.2		 1drfA-3dfrA:
31.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
ASP A  26
LEU A  27
PHE A  30
THR A  45
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.53A 1dyiA-3dfrA:
22.9		 1dyiA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
ASP A  26
LEU A  27
PHE A  30
THR A  45
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.53A 1dyiB-3dfrA:
23.1		 1dyiB-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 11 ALA A   6
LEU A  19
PHE A  30
PRO A  50
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.6A)
MTX  A 164 ( 4.3A)
 0.66A 1dyrA-3dfrA:
20.1		 1dyrA-3dfrA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 9 GLY A  98
THR A  45
ILE A 102
GLY A  17
THR A 126
 NDP  A 163 (-3.8A)
NDP  A 163 (-3.4A)
NDP  A 163 ( 4.1A)
NDP  A 163 (-3.6A)
NDP  A 163 (-4.0A)
 1.22A 1gtfR-3dfrA:
undetectable
1gtfS-3dfrA:
undetectable		 1gtfR-3dfrA:
15.53
1gtfS-3dfrA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 10 ALA A   6
ASP A  26
PHE A  30
SER A  48
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.0A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.50A 1j3jA-3dfrA:
21.0		 1j3jA-3dfrA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 9 ALA A   6
ASP A  26
PHE A  30
SER A  48
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.0A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.44A 1j3jB-3dfrA:
20.5		 1j3jB-3dfrA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
ASP A  26
LEU A  27
PHE A  30
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.53A 1jolA-3dfrA:
23.0		 1jolA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
ASP A  26
LEU A  27
PHE A  30
LEU A  54
PRO A  55
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
None
MTX  A 164 ( 4.3A)
 0.70A 1jolB-3dfrA:
23.1		 1jolB-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 11 ALA A   6
ASP A  26
LEU A  27
PHE A  30
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.60A 1jomA-3dfrA:
22.2		 1jomA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		3 / 3 ARG A 117
ILE A  13
TRP A   5
 None
NDP  A 163 (-3.8A)
None
 0.95A 1m8eB-3dfrA:
undetectable		 1m8eB-3dfrA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		3 / 3 ARG A 117
ILE A  13
TRP A   5
 None
NDP  A 163 (-3.8A)
None
 0.86A 1nodB-3dfrA:
undetectable		 1nodB-3dfrA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		3 / 3 ARG A 117
ILE A  13
TRP A   5
 None
NDP  A 163 (-3.8A)
None
 0.97A 1qomA-3dfrA:
undetectable		 1qomA-3dfrA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		8 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
THR A  45
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.50A 1qzfA-3dfrA:
12.0		 1qzfA-3dfrA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		8 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
THR A  45
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.51A 1qzfB-3dfrA:
20.3		 1qzfB-3dfrA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		8 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
THR A  45
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.51A 1qzfC-3dfrA:
20.3		 1qzfC-3dfrA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		8 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
THR A  45
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.51A 1qzfD-3dfrA:
12.0		 1qzfD-3dfrA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		8 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
THR A  45
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.52A 1qzfE-3dfrA:
12.1		 1qzfE-3dfrA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
ASP A  26
LEU A  27
PHE A  30
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.52A 1ra2A-3dfrA:
22.9		 1ra2A-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
ASP A  26
LEU A  27
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.50A 1ra3A-3dfrA:
23.1		 1ra3A-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  27
PHE A  30
THR A  45
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.55A 1ra8A-3dfrA:
22.8		 1ra8A-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
ASP A  26
LEU A  27
PHE A  30
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.60A 1rb2A-3dfrA:
22.9		 1rb2A-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
ASP A  26
LEU A  27
PHE A  30
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.58A 1rb2B-3dfrA:
22.9		 1rb2B-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 10 ALA A   6
ASP A  26
LEU A  27
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.36A 1rb3A-3dfrA:
23.2		 1rb3A-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
ASP A  26
LEU A  27
SER A  48
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.76A 1rb3B-3dfrA:
23.3		 1rb3B-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  27
PHE A  30
THR A  45
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.56A 1rd7A-3dfrA:
22.5		 1rd7A-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
ASP A  26
LEU A  27
THR A  45
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.43A 1rd7B-3dfrA:
22.5		 1rd7B-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
ASP A  26
LEU A  27
PHE A  30
THR A  45
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.3A)
 0.47A 1re7A-3dfrA:
22.8		 1re7A-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
ASP A  26
LEU A  27
PHE A  30
LEU A  54
PRO A  55
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
None
MTX  A 164 ( 4.3A)
 0.63A 1re7B-3dfrA:
22.6		 1re7B-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
ASP A  26
LEU A  27
THR A  45
LEU A  54
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
 0.44A 1rg7A-3dfrA:
22.4		 1rg7A-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
ASP A  26
LEU A  27
THR A  45
SER A  48
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
NDP  A 163 (-3.4A)
MTX  A 164 (-3.5A)
 0.73A 1rg7A-3dfrA:
22.4		 1rg7A-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ASP A  26
LEU A  27
PHE A  30
SER A  48
LEU A  54
ARG A  57
 MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
 0.67A 1rh3A-3dfrA:
24.1		 1rh3A-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
LEU A  27
PHE A  30
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.55A 1rx2A-3dfrA:
24.3		 1rx2A-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
ASP A  26
LEU A  27
PHE A  30
SER A  48
LEU A  54
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
 0.85A 1rx3A-3dfrA:
24.4		 1rx3A-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
ASP A  26
LEU A  27
PHE A  30
THR A  45
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.56A 1rx7A-3dfrA:
22.2		 1rx7A-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  27
PHE A  30
LEU A  54
PRO A  55
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
None
MTX  A 164 ( 4.3A)
 0.80A 1rx8A-3dfrA:
23.9		 1rx8A-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
ASP A  26
LEU A  27
PHE A  30
THR A  45
LEU A  54
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
 0.60A 1tdrA-3dfrA:
22.9		 1tdrA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 10 ALA A   6
ASP A  26
LEU A  27
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.56A 1tdrB-3dfrA:
23.0		 1tdrB-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_A_ACTA4901_0
(PYRANOSE OXIDASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		4 / 6 THR A  34
PHE A  30
PHE A  49
ASN A  59
 None
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.5A)
None
 1.26A 1tt0A-3dfrA:
undetectable		 1tt0A-3dfrA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_B_ACTB3901_0
(PYRANOSE OXIDASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		4 / 6 THR A  34
PHE A  30
PHE A  49
ASN A  59
 None
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.5A)
None
 1.25A 1tt0B-3dfrA:
undetectable		 1tt0B-3dfrA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_C_ACTC6901_0
(PYRANOSE OXIDASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		4 / 6 THR A  34
PHE A  30
PHE A  49
ASN A  59
 None
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.5A)
None
 1.27A 1tt0C-3dfrA:
undetectable		 1tt0C-3dfrA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_D_ACTD5901_0
(PYRANOSE OXIDASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		4 / 6 THR A  34
PHE A  30
PHE A  49
ASN A  59
 None
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.5A)
None
 1.25A 1tt0D-3dfrA:
undetectable		 1tt0D-3dfrA:
13.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
LEU A  19
SER A  48
LEU A  54
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
 0.76A 1u72A-3dfrA:
21.5		 1u72A-3dfrA:
31.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
LEU A  19
SER A  48
PRO A  50
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.6A)
MTX  A 164 ( 2.9A)
 0.64A 1u72A-3dfrA:
21.5		 1u72A-3dfrA:
31.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 LEU A  19
SER A  48
LEU A  54
ARG A  57
VAL A  41
 MTX  A 164 (-4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
None
 1.19A 1u72A-3dfrA:
21.5		 1u72A-3dfrA:
31.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 LEU A  19
SER A  48
PRO A  50
ARG A  57
VAL A  41
 MTX  A 164 (-4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.6A)
MTX  A 164 ( 2.9A)
None
 1.21A 1u72A-3dfrA:
21.5		 1u72A-3dfrA:
31.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  19
ASP A  26
PHE A  30
SER A  48
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.0A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.57A 2bl9A-3dfrA:
21.2		 2bl9A-3dfrA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 11 ALA A   6
ASP A  26
PHE A  30
SER A  48
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.0A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.56A 2blaA-3dfrA:
21.0		 2blaA-3dfrA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  19
THR A  45
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.69A 2cd2A-3dfrA:
20.5		 2cd2A-3dfrA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  19
THR A  45
PRO A  50
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.6A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.88A 2cd2A-3dfrA:
20.5		 2cd2A-3dfrA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  27
PHE A  30
LEU A  54
PRO A  55
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
None
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.91A 2d0kA-3dfrA:
22.1		 2d0kA-3dfrA:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  27
PHE A  30
THR A  45
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.62A 2d0kB-3dfrA:
22.3		 2d0kB-3dfrA:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
ASP A  26
LEU A  27
LEU A  54
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
 0.55A 2drcA-3dfrA:
23.1		 2drcA-3dfrA:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
ASP A  26
LEU A  27
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.56A 2drcB-3dfrA:
23.3		 2drcB-3dfrA:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		3 / 3 ARG A 117
ILE A  13
TRP A   5
 None
NDP  A 163 (-3.8A)
None
 0.91A 2nodB-3dfrA:
undetectable		 2nodB-3dfrA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
PHE A  30
LEU A  54
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
 0.51A 2oipA-3dfrA:
21.2		 2oipA-3dfrA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
PHE A  30
THR A  45
LEU A  54
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
 0.42A 2oipA-3dfrA:
21.2		 2oipA-3dfrA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		8 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
PHE A  30
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.49A 2oipB-3dfrA:
19.3		 2oipB-3dfrA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		8 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
PHE A  30
THR A  45
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.40A 2oipB-3dfrA:
19.3		 2oipB-3dfrA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		8 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
PHE A  30
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.50A 2oipC-3dfrA:
20.8		 2oipC-3dfrA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		8 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
PHE A  30
THR A  45
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.46A 2oipC-3dfrA:
20.8		 2oipC-3dfrA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
PHE A  30
LEU A  54
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
 0.50A 2oipD-3dfrA:
21.5		 2oipD-3dfrA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
PHE A  30
THR A  45
LEU A  54
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
 0.43A 2oipD-3dfrA:
21.5		 2oipD-3dfrA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
PHE A  30
LEU A  54
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
 0.53A 2oipE-3dfrA:
20.7		 2oipE-3dfrA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
PHE A  30
THR A  45
LEU A  54
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
 0.46A 2oipE-3dfrA:
20.7		 2oipE-3dfrA:
13.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
LEU A  27
LEU A  54
PRO A  55
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
None
MTX  A 164 ( 2.9A)
 0.66A 2qk8A-3dfrA:
25.0		 2qk8A-3dfrA:
38.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 11 ALA A   6
PHE A  30
THR A  45
PRO A  50
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.6A)
MTX  A 164 ( 4.3A)
 0.55A 2w3aA-3dfrA:
20.9		 2w3aA-3dfrA:
31.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 10 ALA A   6
PHE A  30
THR A  45
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.56A 2w3aB-3dfrA:
20.8		 2w3aB-3dfrA:
31.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  19
PHE A  30
THR A  45
PRO A  50
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.6A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.68A 2w3bA-3dfrA:
20.8		 2w3bA-3dfrA:
31.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  19
PHE A  30
PRO A  50
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.6A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.71A 2w3bB-3dfrA:
20.8		 2w3bB-3dfrA:
31.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  19
PHE A  30
PRO A  50
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.6A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.71A 2w3mA-3dfrA:
21.1		 2w3mA-3dfrA:
31.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  19
PHE A  30
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.59A 2w3mB-3dfrA:
21.1		 2w3mB-3dfrA:
31.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 TRP A   5
ALA A   6
ASP A  26
LEU A  27
LEU A  54
THR A 116
 None
MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 1.33A 2w3vA-3dfrA:
22.8		 2w3vA-3dfrA:
35.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 TRP A   5
ALA A   6
ASP A  26
LEU A  27
PHE A  30
THR A 116
 None
MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.3A)
 0.47A 2w3vA-3dfrA:
22.8		 2w3vA-3dfrA:
35.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 TRP A   5
ALA A   6
ASP A  26
LEU A  27
SER A  48
THR A 116
 None
MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.76A 2w3vA-3dfrA:
22.8		 2w3vA-3dfrA:
35.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 10 LEU A   4
ALA A   6
LEU A  19
ASP A  26
LEU A  27
SER A  48
THR A 116
 MTX  A 164 ( 4.1A)
MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.63A 2w9gA-3dfrA:
24.0		 2w9gA-3dfrA:
35.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 10 LEU A   4
ALA A   6
LEU A  19
ASP A  26
LEU A  27
SER A  48
THR A 116
 MTX  A 164 ( 4.1A)
MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.64A 2w9hA-3dfrA:
23.7		 2w9hA-3dfrA:
35.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 10 LEU A   4
ALA A   6
LEU A  19
SER A  48
PHE A  30
THR A 116
 MTX  A 164 ( 4.1A)
MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.3A)
 1.50A 2w9hA-3dfrA:
23.7		 2w9hA-3dfrA:
35.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 11 ALA A   6
LEU A  19
ASP A  26
LEU A  27
SER A  48
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.72A 2w9sA-3dfrA:
23.9		 2w9sA-3dfrA:
35.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 11 ALA A   6
LEU A  19
ASP A  26
LEU A  27
SER A  48
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.71A 2w9sB-3dfrA:
23.9		 2w9sB-3dfrA:
35.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 10 ALA A   6
LEU A  19
ASP A  26
SER A  48
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.60A 2w9sC-3dfrA:
23.9		 2w9sC-3dfrA:
35.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 10 ALA A   6
LEU A  19
ASP A  26
LEU A  27
SER A  48
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.71A 2w9sD-3dfrA:
23.3		 2w9sD-3dfrA:
35.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		4 / 8 ALA A   6
LEU A  19
ASP A  26
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.50A 2w9sE-3dfrA:
23.3		 2w9sE-3dfrA:
35.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 10 ALA A   6
LEU A  19
ASP A  26
LEU A  27
SER A  48
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.68A 2w9sF-3dfrA:
23.3		 2w9sF-3dfrA:
35.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 GLN A 101
SER A  48
GLY A  98
GLY A  42
MET A 128
 NDP  A 163 ( 3.6A)
MTX  A 164 (-3.5A)
NDP  A 163 (-3.8A)
NDP  A 163 ( 3.6A)
None
 1.24A 2zw9A-3dfrA:
undetectable		 2zw9A-3dfrA:
13.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
LEU A  27
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.41A 2zzaA-3dfrA:
24.2		 2zzaA-3dfrA:
37.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 11 ALA A   6
LEU A  27
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.42A 2zzaB-3dfrA:
24.1		 2zzaB-3dfrA:
37.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		3 / 3 LEU A  23
TRP A   5
TYR A  29
 None
 0.93A 3aicA-3dfrA:
undetectable		 3aicA-3dfrA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		3 / 3 LEU A  23
TRP A   5
TYR A  29
 None
 0.94A 3aicB-3dfrA:
undetectable		 3aicB-3dfrA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		3 / 3 LEU A  23
TRP A   5
TYR A  29
 None
 0.94A 3aicE-3dfrA:
undetectable		 3aicE-3dfrA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		3 / 3 LEU A  23
TRP A   5
TYR A  29
 None
 1.00A 3aicF-3dfrA:
undetectable		 3aicF-3dfrA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		3 / 3 LEU A  23
TRP A   5
TYR A  29
 None
 0.88A 3aicG-3dfrA:
undetectable		 3aicG-3dfrA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		3 / 3 LEU A  23
TRP A   5
TYR A  29
 None
 0.93A 3aicH-3dfrA:
undetectable		 3aicH-3dfrA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
ASP A  26
THR A  45
LEU A  54
PRO A  55
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
None
MTX  A 164 ( 2.9A)
 0.69A 3cl9A-3dfrA:
19.4		 3cl9A-3dfrA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
ASP A  26
THR A  45
PRO A  50
PRO A  55
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.6A)
None
MTX  A 164 ( 2.9A)
 0.65A 3cl9A-3dfrA:
19.4		 3cl9A-3dfrA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
ASP A  26
THR A  45
SER A  48
PRO A  50
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
NDP  A 163 (-3.4A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.6A)
 0.65A 3cl9A-3dfrA:
19.4		 3cl9A-3dfrA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
ASP A  26
PHE A  30
THR A  45
SER A  48
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 (-3.5A)
 0.60A 3clbB-3dfrA:
18.4		 3clbB-3dfrA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
ASP A  26
THR A  45
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.40A 3clbC-3dfrA:
19.4		 3clbC-3dfrA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
ASP A  26
THR A  45
PRO A  50
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.6A)
MTX  A 164 ( 4.3A)
 0.66A 3clbC-3dfrA:
19.4		 3clbC-3dfrA:
18.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
LEU A  19
LEU A  27
LEU A  54
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
 0.59A 3datA-3dfrA:
25.0		 3datA-3dfrA:
38.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
ASP A  26
LEU A  27
LEU A  54
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
 0.41A 3dauA-3dfrA:
24.6		 3dauA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
ASP A  26
LEU A  27
LEU A  54
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
 0.59A 3drcA-3dfrA:
23.1		 3drcA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
ASP A  26
LEU A  27
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.58A 3drcB-3dfrA:
23.3		 3drcB-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		3 / 3 ARG A 117
ILE A  13
TRP A   5
 None
NDP  A 163 (-3.8A)
None
 1.02A 3e68A-3dfrA:
undetectable		 3e68A-3dfrA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		3 / 3 ARG A 117
ILE A  13
TRP A   5
 None
NDP  A 163 (-3.8A)
None
 0.96A 3e6tB-3dfrA:
undetectable		 3e6tB-3dfrA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		3 / 3 ARG A 117
ILE A  13
TRP A   5
 None
NDP  A 163 (-3.8A)
None
 0.96A 3e7iB-3dfrA:
undetectable		 3e7iB-3dfrA:
16.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  19
SER A  48
PRO A  50
LEU A  54
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.6A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
 0.83A 3eigA-3dfrA:
20.8		 3eigA-3dfrA:
31.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 10 ALA A   6
LEU A  19
LEU A  27
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.69A 3fl9E-3dfrA:
23.6		 3fl9E-3dfrA:
37.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
LEU A  19
LEU A  27
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.68A 3fl9G-3dfrA:
23.5		 3fl9G-3dfrA:
37.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 11 LEU A   4
ALA A   6
LEU A  19
ASP A  26
LEU A  27
SER A  48
THR A 116
 MTX  A 164 ( 4.1A)
MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.65A 3frbX-3dfrA:
23.9		 3frbX-3dfrA:
34.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 9 ALA A   6
LEU A  19
ASP A  26
LEU A  27
SER A  48
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.67A 3freX-3dfrA:
23.9		 3freX-3dfrA:
35.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		8 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
PHE A  30
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.54A 3hj3A-3dfrA:
21.9		 3hj3A-3dfrA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		8 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
PHE A  30
THR A  45
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.47A 3hj3A-3dfrA:
21.9		 3hj3A-3dfrA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
PHE A  30
LEU A  54
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
 0.54A 3hj3B-3dfrA:
21.9		 3hj3B-3dfrA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
PHE A  30
THR A  45
LEU A  54
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
 0.43A 3hj3B-3dfrA:
21.9		 3hj3B-3dfrA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		8 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
PHE A  30
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.51A 3hj3C-3dfrA:
10.6		 3hj3C-3dfrA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		8 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
PHE A  30
THR A  45
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.49A 3hj3C-3dfrA:
10.6		 3hj3C-3dfrA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
PHE A  30
LEU A  54
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
 0.54A 3hj3D-3dfrA:
4.9		 3hj3D-3dfrA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
PHE A  30
THR A  45
LEU A  54
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
 0.48A 3hj3D-3dfrA:
4.9		 3hj3D-3dfrA:
14.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
LEU A  27
SER A  48
LEU A  54
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
 0.82A 3ia4A-3dfrA:
24.1		 3ia4A-3dfrA:
37.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
LEU A  27
SER A  48
LEU A  54
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
 0.87A 3ia4B-3dfrA:
24.3		 3ia4B-3dfrA:
37.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  27
PHE A  30
SER A  48
LEU A  54
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
 0.75A 3ia4C-3dfrA:
24.1		 3ia4C-3dfrA:
37.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  27
PHE A  30
SER A  48
LEU A  54
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
 0.80A 3ia4D-3dfrA:
24.1		 3ia4D-3dfrA:
37.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 TRP A   5
ALA A   6
LEU A  19
LEU A  27
LEU A  54
ARG A  57
THR A 116
 None
MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.38A 3ix9A-3dfrA:
25.6		 3ix9A-3dfrA:
32.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  19
LEU A  27
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.40A 3ix9B-3dfrA:
25.8		 3ix9B-3dfrA:
32.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 10 ALA A   6
LEU A  19
LEU A  27
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.37A 3jw5B-3dfrA:
25.0		 3jw5B-3dfrA:
37.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
ASP A  26
THR A  45
LEU A  54
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
 0.62A 3k2hA-3dfrA:
22.4		 3k2hA-3dfrA:
15.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 11 ALA A   6
PHE A  30
THR A  45
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.67A 3n0hA-3dfrA:
20.8		 3n0hA-3dfrA:
31.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
ASP A  26
THR A  45
PRO A  50
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.6A)
MTX  A 164 ( 4.3A)
 0.43A 3nrrA-3dfrA:
21.7		 3nrrA-3dfrA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
HIS A  22
ASP A  26
THR A  45
PRO A  50
THR A 116
 MTX  A 164 (-3.8A)
None
MTX  A 164 ( 2.9A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.6A)
MTX  A 164 ( 4.3A)
 1.13A 3nrrB-3dfrA:
22.6		 3nrrB-3dfrA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		3 / 3 ARG A 117
ILE A  13
TRP A   5
 None
NDP  A 163 (-3.8A)
None
 0.98A 3nw2A-3dfrA:
undetectable		 3nw2A-3dfrA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		3 / 3 ARG A 117
ILE A  13
TRP A   5
 None
NDP  A 163 (-3.8A)
None
 0.93A 3nw2B-3dfrA:
undetectable		 3nw2B-3dfrA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
ASP A  26
PHE A  30
THR A  45
SER A  48
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.46A 3qfxA-3dfrA:
19.7		 3qfxA-3dfrA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
ASP A  26
PHE A  30
THR A  45
SER A  48
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.46A 3qfxB-3dfrA:
19.7		 3qfxB-3dfrA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 10 ALA A   6
ASP A  26
PHE A  30
SER A  48
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.0A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.51A 3qg2A-3dfrA:
20.9		 3qg2A-3dfrA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 11 ALA A   6
ASP A  26
PHE A  30
SER A  48
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.0A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.46A 3qg2B-3dfrA:
20.5		 3qg2B-3dfrA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 10 ALA A   6
ASP A  26
PHE A  30
SER A  48
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.0A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.50A 3qgtA-3dfrA:
20.9		 3qgtA-3dfrA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 10 ALA A   6
ASP A  26
PHE A  30
SER A  48
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.0A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.47A 3qgtB-3dfrA:
20.4		 3qgtB-3dfrA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 10 ALA A   6
ASP A  26
PHE A  30
SER A  48
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.0A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 1.01A 3qgtB-3dfrA:
20.4		 3qgtB-3dfrA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  27
PHE A  30
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.58A 3ql0A-3dfrA:
24.3		 3ql0A-3dfrA:
29.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
ASP A  26
LEU A  27
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.30A 3ql3A-3dfrA:
24.4		 3ql3A-3dfrA:
29.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
PHE A  30
THR A  45
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.70A 3s3vA-3dfrA:
20.6		 3s3vA-3dfrA:
31.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		4 / 7 PHE A 106
PHE A  83
ALA A  80
LEU A  62
 None
None
None
NDP  A 163 ( 3.9A)
 1.00A 3t3sC-3dfrA:
undetectable		 3t3sC-3dfrA:
16.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 9 ALA A   6
LEU A  19
ASP A  26
PHE A  30
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.3A)
 0.29A 3tq8A-3dfrA:
24.7		 3tq8A-3dfrA:
32.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 9 ALA A   6
LEU A  19
ASP A  26
SER A  48
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.60A 3tq8A-3dfrA:
24.7		 3tq8A-3dfrA:
32.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		8 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
SER A  48
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.74A 3tq9A-3dfrA:
24.6		 3tq9A-3dfrA:
32.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		8 / 11 ALA A   6
LEU A  19
ASP A  26
LEU A  27
THR A  45
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.58A 3tqbA-3dfrA:
24.3		 3tqbA-3dfrA:
32.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 10 ASP A  26
PHE A  30
THR A  45
SER A  48
THR A 116
 MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.51A 3um5A-3dfrA:
20.9		 3um5A-3dfrA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 10 ASP A  26
PHE A  30
THR A  45
SER A  48
THR A 116
 MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.56A 3um5B-3dfrA:
20.5		 3um5B-3dfrA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
PHE A  30
THR A  45
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.66A 4cd2A-3dfrA:
19.5		 4cd2A-3dfrA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
ASP A  26
LEU A  27
THR A  45
LEU A  54
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
 0.56A 4dfrA-3dfrA:
23.0		 4dfrA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
ASP A  26
LEU A  27
THR A  45
SER A  48
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
NDP  A 163 (-3.4A)
MTX  A 164 (-3.5A)
 0.93A 4dfrA-3dfrA:
23.0		 4dfrA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
ASP A  26
LEU A  27
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.56A 4dfrB-3dfrA:
23.4		 4dfrB-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  19
PHE A  30
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.88A 4eckA-3dfrA:
19.6		 4eckA-3dfrA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  19
ASP A  26
PHE A  30
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.91A 4eckB-3dfrA:
19.5		 4eckB-3dfrA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 11 ALA A   6
ASP A  26
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.52A 4eilA-3dfrA:
21.2		 4eilA-3dfrA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 10 ALA A   6
ASP A  26
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.62A 4eilB-3dfrA:
21.4		 4eilB-3dfrA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 11 ALA A   6
ASP A  26
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.52A 4eilC-3dfrA:
21.2		 4eilC-3dfrA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 11 ALA A   6
ASP A  26
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.50A 4eilE-3dfrA:
21.9		 4eilE-3dfrA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 9 ALA A   6
ASP A  26
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.62A 4eilF-3dfrA:
20.7		 4eilF-3dfrA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 10 ALA A   6
ASP A  26
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.53A 4eilG-3dfrA:
21.3		 4eilG-3dfrA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
LEU A  27
PHE A  30
THR A  45
LEU A  54
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
 0.62A 4ej1A-3dfrA:
22.0		 4ej1A-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  27
PHE A  30
THR A  45
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.74A 4ej1B-3dfrA:
22.0		 4ej1B-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  27
PHE A  30
THR A  45
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.67A 4fhbA-3dfrA:
22.8		 4fhbA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 10 ALA A   6
LEU A  19
SER A  48
PRO A  50
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.6A)
MTX  A 164 ( 4.3A)
 0.84A 4g8zX-3dfrA:
20.2		 4g8zX-3dfrA:
28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
ASP A  26
LEU A  27
SER A  48
LEU A  54
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
 0.78A 4gh8A-3dfrA:
24.0		 4gh8A-3dfrA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
ASP A  26
LEU A  27
SER A  48
PRO A  50
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.6A)
 0.76A 4gh8A-3dfrA:
24.0		 4gh8A-3dfrA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
ASP A  26
LEU A  27
SER A  48
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 2.9A)
 0.67A 4gh8B-3dfrA:
23.8		 4gh8B-3dfrA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
ASP A  26
LEU A  27
SER A  48
PRO A  50
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.6A)
 0.71A 4gh8B-3dfrA:
23.8		 4gh8B-3dfrA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
LEU A  27
PHE A  30
THR A  45
LEU A  54
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
 0.60A 4i13A-3dfrA:
22.6		 4i13A-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		3 / 3 ASP A  26
ARG A  57
THR A 116
 MTX  A 164 ( 2.9A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.32A 4i13A-3dfrA:
22.6		 4i13A-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 11 ALA A   6
ASP A  26
LEU A  27
PHE A  30
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.59A 4i1nA-3dfrA:
22.6		 4i1nA-3dfrA:
29.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  19
PHE A  30
THR A  45
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.49A 4kebB-3dfrA:
21.1		 4kebB-3dfrA:
31.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
LEU A  19
PHE A  30
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.48A 4kfjB-3dfrA:
21.3		 4kfjB-3dfrA:
31.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
LEU A  19
PHE A  30
PRO A  50
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.6A)
MTX  A 164 ( 4.3A)
 0.51A 4kfjB-3dfrA:
21.3		 4kfjB-3dfrA:
31.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		4 / 4 ASP A  26
LEU A  27
ARG A  57
THR A 116
 MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.38A 4kjjA-3dfrA:
23.1		 4kjjA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		4 / 4 ASP A  26
LEU A  27
ARG A  57
THR A 116
 MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.35A 4kjkA-3dfrA:
24.0		 4kjkA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
PHE A  30
THR A  45
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.48A 4kjlA-3dfrA:
23.7		 4kjlA-3dfrA:
29.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 10 TRP A   5
ALA A   6
ASP A  26
LEU A  54
THR A 116
 None
MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 1.02A 4km0A-3dfrA:
21.2		 4km0A-3dfrA:
31.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 10 TRP A   5
ALA A   6
ASP A  26
PHE A  30
THR A  45
THR A 116
 None
MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.3A)
 0.68A 4km0A-3dfrA:
21.2		 4km0A-3dfrA:
31.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 TRP A   5
ALA A   6
ASP A  26
LEU A  54
THR A 116
 None
MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 1.04A 4km0B-3dfrA:
21.5		 4km0B-3dfrA:
31.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 TRP A   5
ALA A   6
ASP A  26
PHE A  30
THR A  45
THR A 116
 None
MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.3A)
 0.64A 4km0B-3dfrA:
21.5		 4km0B-3dfrA:
31.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
ASP A  26
PHE A  30
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.57A 4km2A-3dfrA:
21.8		 4km2A-3dfrA:
31.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
ASP A  26
PHE A  30
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.36A 4km2B-3dfrA:
21.3		 4km2B-3dfrA:
31.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		8 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
SER A  48
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.80A 4ky8A-3dfrA:
14.4		 4ky8A-3dfrA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.53A 4ky8B-3dfrA:
15.4		 4ky8B-3dfrA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
SER A  48
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.73A 4ky8B-3dfrA:
15.4		 4ky8B-3dfrA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.48A 4ky8C-3dfrA:
21.5		 4ky8C-3dfrA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
SER A  48
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.62A 4ky8C-3dfrA:
21.5		 4ky8C-3dfrA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.48A 4ky8D-3dfrA:
18.0		 4ky8D-3dfrA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
SER A  48
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.50A 4ky8D-3dfrA:
18.0		 4ky8D-3dfrA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.54A 4ky8E-3dfrA:
21.5		 4ky8E-3dfrA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
SER A  48
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.80A 4ky8E-3dfrA:
21.5		 4ky8E-3dfrA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 11 ALA A   6
ASP A  26
THR A  45
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.58A 4kyaA-3dfrA:
21.3		 4kyaA-3dfrA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
ASP A  26
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.62A 4kyaB-3dfrA:
21.3		 4kyaB-3dfrA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 10 ALA A   6
ASP A  26
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.57A 4kyaC-3dfrA:
15.5		 4kyaC-3dfrA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
ASP A  26
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.64A 4kyaD-3dfrA:
13.9		 4kyaD-3dfrA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 11 ALA A   6
ASP A  26
THR A  45
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.60A 4kyaE-3dfrA:
21.3		 4kyaE-3dfrA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
ASP A  26
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.63A 4kyaF-3dfrA:
13.8		 4kyaF-3dfrA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 11 ALA A   6
ASP A  26
THR A  45
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.60A 4kyaG-3dfrA:
21.3		 4kyaG-3dfrA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
ASP A  26
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.65A 4kyaH-3dfrA:
20.6		 4kyaH-3dfrA:
14.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
ASP A  26
PRO A  50
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.6A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.73A 4m2xC-3dfrA:
22.1		 4m2xC-3dfrA:
34.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  19
PHE A  30
THR A  45
PRO A  50
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.6A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.66A 4m6kA-3dfrA:
21.6		 4m6kA-3dfrA:
31.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
LEU A  27
PHE A  30
THR A  45
LEU A  54
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
 0.52A 4nx6A-3dfrA:
24.3		 4nx6A-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
LEU A  27
PHE A  30
THR A  45
LEU A  54
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
 0.56A 4nx7A-3dfrA:
24.3		 4nx7A-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
PHE A  30
THR A  45
LEU A  54
PRO A  55
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
None
 0.70A 4p3qA-3dfrA:
24.2		 4p3qA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		4 / 5 ASP A  26
LEU A  27
ARG A  57
THR A 116
 MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.51A 4p3qA-3dfrA:
24.2		 4p3qA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
LEU A  27
PHE A  30
THR A  45
LEU A  54
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
 0.56A 4p3rA-3dfrA:
24.4		 4p3rA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		3 / 3 ASP A  26
ARG A  57
THR A 116
 MTX  A 164 ( 2.9A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.34A 4p3rA-3dfrA:
24.4		 4p3rA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 11 ALA A   6
ASP A  26
LEU A  27
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.54A 4p66A-3dfrA:
24.4		 4p66A-3dfrA:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 11 ASP A  26
PHE A  30
SER A  48
ARG A  57
THR A 116
 MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.0A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.53A 4p68A-3dfrA:
23.7		 4p68A-3dfrA:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
LEU A  27
PHE A  30
THR A  45
LEU A  54
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
 0.57A 4pssA-3dfrA:
undetectable		 4pssA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  27
PHE A  30
THR A  45
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.49A 4pstA-3dfrA:
undetectable		 4pstA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
LEU A  27
PHE A  30
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.55A 4psyA-3dfrA:
24.4		 4psyA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
THR A  45
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.55A 4pthA-3dfrA:
24.2		 4pthA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		3 / 3 ASP A  26
LEU A  27
PHE A  30
 MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
 0.18A 4pthA-3dfrA:
24.2		 4pthA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  27
PHE A  30
THR A  45
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.42A 4ptjA-3dfrA:
24.2		 4ptjA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.52A 4q0dA-3dfrA:
21.6		 4q0dA-3dfrA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.52A 4q0dB-3dfrA:
21.7		 4q0dB-3dfrA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.51A 4q0dC-3dfrA:
21.5		 4q0dC-3dfrA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
SER A  48
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.64A 4q0dC-3dfrA:
21.5		 4q0dC-3dfrA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.52A 4q0dD-3dfrA:
21.6		 4q0dD-3dfrA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
SER A  48
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.65A 4q0dD-3dfrA:
21.6		 4q0dD-3dfrA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  19
ASP A  26
LEU A  27
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 (-4.5A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.51A 4q0dE-3dfrA:
21.6		 4q0dE-3dfrA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
ASP A  26
LEU A  27
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.50A 4qi9A-3dfrA:
21.4		 4qi9A-3dfrA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
ASP A  26
LEU A  27
SER A  48
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.69A 4qi9A-3dfrA:
21.4		 4qi9A-3dfrA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
ASP A  26
LEU A  27
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.56A 4qi9B-3dfrA:
21.8		 4qi9B-3dfrA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 11 ALA A   6
ASP A  26
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.49A 4qi9C-3dfrA:
21.0		 4qi9C-3dfrA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
ASP A  26
LEU A  27
PHE A  30
THR A  45
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.51A 4qleA-3dfrA:
23.3		 4qleA-3dfrA:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 11 ALA A   6
ASP A  26
LEU A  27
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.54A 4qleB-3dfrA:
23.1		 4qleB-3dfrA:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 11 ALA A   6
ASP A  26
LEU A  27
SER A  48
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.78A 4qleB-3dfrA:
23.1		 4qleB-3dfrA:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 11 ALA A   6
ASP A  26
LEU A  27
PHE A  30
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.51A 4qlfA-3dfrA:
20.2		 4qlfA-3dfrA:
29.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
ASP A  26
LEU A  27
PHE A  30
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.55A 4qlgA-3dfrA:
23.1		 4qlgA-3dfrA:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		8 / 12 ALA A   6
ASP A  26
LEU A  27
PHE A  30
THR A  45
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.47A 4qlgB-3dfrA:
23.0		 4qlgB-3dfrA:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
ASP A  26
LEU A  27
PHE A  30
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.53A 4rgcA-3dfrA:
24.4		 4rgcA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  27
PHE A  30
THR A  45
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.53A 4x5fA-3dfrA:
23.0		 4x5fA-3dfrA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  27
PHE A  30
THR A  45
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.53A 4x5fB-3dfrA:
23.1		 4x5fB-3dfrA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
ASP A  26
LEU A  27
PHE A  30
THR A  45
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.48A 4x5gA-3dfrA:
23.0		 4x5gA-3dfrA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  27
THR A  45
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.56A 4x5gB-3dfrA:
23.1		 4x5gB-3dfrA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  27
PHE A  30
THR A  45
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.63A 4x5hA-3dfrA:
22.4		 4x5hA-3dfrA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  27
PHE A  30
THR A  45
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.71A 4x5iA-3dfrA:
22.2		 4x5iA-3dfrA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
LEU A  27
PHE A  30
THR A  45
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.3A)
 0.49A 4x5jA-3dfrA:
22.2		 4x5jA-3dfrA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
LEU A  27
PHE A  30
THR A  45
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.3A)
 0.31A 5e8qA-3dfrA:
22.9		 5e8qA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		3 / 3 ASP A  26
LEU A  54
ARG A  57
 MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
 0.38A 5e8qA-3dfrA:
22.9		 5e8qA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  27
PHE A  30
THR A  45
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.55A 5e8qB-3dfrA:
23.1		 5e8qB-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  27
PHE A  30
THR A  45
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.55A 5eajA-3dfrA:
22.9		 5eajA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  27
PHE A  30
THR A  45
LEU A  54
PRO A  55
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
None
MTX  A 164 ( 4.3A)
 0.75A 5eajB-3dfrA:
23.2		 5eajB-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
ASP A  26
LEU A  27
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.54A 5hi6A-3dfrA:
23.2		 5hi6A-3dfrA:
29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
ASP A  26
LEU A  27
SER A  48
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.3A)
 0.71A 5hi6A-3dfrA:
23.2		 5hi6A-3dfrA:
29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
ASP A  26
LEU A  27
SER A  48
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 (-3.5A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.95A 5hi6B-3dfrA:
22.9		 5hi6B-3dfrA:
29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		4 / 8 ALA A   6
ASP A  26
LEU A  27
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.3A)
 0.33A 5uihA-3dfrA:
22.0		 5uihA-3dfrA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  27
PHE A  30
THR A  45
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.51A 5ujxA-3dfrA:
22.9		 5ujxA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		7 / 12 ALA A   6
LEU A  27
PHE A  30
THR A  45
LEU A  54
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.56A 5ujxB-3dfrA:
23.1		 5ujxB-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  27
PHE A  30
THR A  45
ARG A  57
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.3A)
 0.45A 5z6fA-3dfrA:
24.2		 5z6fA-3dfrA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  27
PHE A  30
THR A  45
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.51A 5z6jA-3dfrA:
24.4		 5z6jA-3dfrA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 12 ALA A   6
LEU A  27
PHE A  30
THR A  45
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.55A 5z6kA-3dfrA:
24.3		 5z6kA-3dfrA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6L_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 9 ALA A   6
ASP A  26
LEU A  27
PRO A  55
ARG A  57
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
None
MTX  A 164 ( 2.9A)
 0.63A 5z6lA-3dfrA:
23.6		 5z6lA-3dfrA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		6 / 11 ALA A   6
ASP A  26
LEU A  27
PHE A  30
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 4.0A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 1.08A 5z6mA-3dfrA:
22.7		 5z6mA-3dfrA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 10 ALA A   6
ASP A  26
PHE A  30
THR A  45
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.3A)
 0.38A 6aogA-3dfrA:
21.1		 6aogA-3dfrA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 10 ALA A   6
ASP A  26
PHE A  30
THR A  45
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.3A)
 0.44A 6aogB-3dfrA:
21.1		 6aogB-3dfrA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A  32
VAL A  74
VAL A  82
LEU A 114
ALA A   2
 None
 1.02A 6djzC-3dfrA:
undetectable		 6djzC-3dfrA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		5 / 12 ALA A   6
PHE A  30
THR A  45
LEU A  54
THR A 116
 MTX  A 164 (-3.8A)
MTX  A 164 ( 4.0A)
NDP  A 163 (-3.4A)
MTX  A 164 ( 4.4A)
MTX  A 164 ( 4.3A)
 0.44A 7dfrA-3dfrA:
24.3		 7dfrA-3dfrA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 3dfr DIHYDROFOLATE
REDUCTASE
(Lactobacillus
casei) 		3 / 3 ASP A  26
LEU A  27
ARG A  57
 MTX  A 164 ( 2.9A)
MTX  A 164 ( 4.5A)
MTX  A 164 ( 2.9A)
 0.35A 7dfrA-3dfrA:
24.3		 7dfrA-3dfrA:
29.27