SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dg7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_0
(NEURAMINIDASE)		 3dg7 MUCONATE
CYCLOISOMERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLU A 243
ILE A 263
GLU A 218
GLU A 217
LYS A 160
 MUC  A1001 ( 4.5A)
None
None
MG  A2001 ( 2.9A)
MUC  A1001 ( 2.7A)
 1.47A 1l7hA-3dg7A:
undetectable		 1l7hA-3dg7A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 3dg7 MUCONATE
CYCLOISOMERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 LEU A 351
ALA A  48
ALA A  46
LEU A 332
PHE A 272
 None
 1.29A 1rlbE-3dg7A:
undetectable		 1rlbE-3dg7A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 3dg7 MUCONATE
CYCLOISOMERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 302
GLY A 350
ILE A 353
LEU A 114
ILE A  42
 None
 1.13A 1x1aA-3dg7A:
undetectable		 1x1aA-3dg7A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 3dg7 MUCONATE
CYCLOISOMERASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 SER A 201
GLU A 218
ASP A 223
 None
 0.90A 2avdB-3dg7A:
undetectable		 2avdB-3dg7A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 3dg7 MUCONATE
CYCLOISOMERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 VAL A 118
LEU A  33
ILE A 355
LEU A 332
 None
 1.03A 2byoA-3dg7A:
undetectable		 2byoA-3dg7A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 3dg7 MUCONATE
CYCLOISOMERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ILE A 355
LEU A  33
LEU A 332
ASP A 330
 None
 1.04A 2rlfA-3dg7A:
undetectable
2rlfD-3dg7A:
undetectable		 2rlfA-3dg7A:
8.64
2rlfD-3dg7A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3dg7 MUCONATE
CYCLOISOMERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 319
SER A 264
ASN A 293
LEU A 321
LEU A 343
 None
 1.38A 3cjtK-3dg7A:
undetectable		 3cjtK-3dg7A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3dg7 MUCONATE
CYCLOISOMERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 CYH A 303
THR A 304
THR A 301
GLU A 320
LEU A 336
 None
None
None
MUC  A1001 ( 4.7A)
None
 1.18A 3gwxB-3dg7A:
undetectable		 3gwxB-3dg7A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3dg7 MUCONATE
CYCLOISOMERASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A 118
SER A 306
LEU A 351
 None
 0.71A 3n8xA-3dg7A:
undetectable		 3n8xA-3dg7A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3dg7 MUCONATE
CYCLOISOMERASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 SER A 244
ASP A 191
ASP A 171
 None
MG  A2001 ( 2.6A)
None
 0.91A 3uj7A-3dg7A:
undetectable		 3uj7A-3dg7A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 3dg7 MUCONATE
CYCLOISOMERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ALA A 302
ILE A 353
ILE A 355
HIS A  31
LEU A  33
 None
 1.20A 4dtaA-3dg7A:
undetectable		 4dtaA-3dg7A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA907_0
(PROTEIN ARGONAUTE-2)		 3dg7 MUCONATE
CYCLOISOMERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ALA A 268
LYS A 266
THR A 301
THR A 304
 None
MUC  A1001 (-2.9A)
None
None
 1.39A 4w5oA-3dg7A:
4.0		 4w5oA-3dg7A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3dg7 MUCONATE
CYCLOISOMERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ALA A 268
LYS A 266
THR A 301
THR A 304
 None
MUC  A1001 (-2.9A)
None
None
 1.42A 4w5qA-3dg7A:
4.0		 4w5qA-3dg7A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3dg7 MUCONATE
CYCLOISOMERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ALA A 268
LYS A 266
THR A 301
THR A 304
 None
MUC  A1001 (-2.9A)
None
None
 1.40A 4z4cA-3dg7A:
3.9		 4z4cA-3dg7A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3dg7 MUCONATE
CYCLOISOMERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ALA A 268
LYS A 266
THR A 301
THR A 304
 None
MUC  A1001 (-2.9A)
None
None
 1.41A 4z4dA-3dg7A:
5.2		 4z4dA-3dg7A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA907_0
(PROTEIN ARGONAUTE-2)		 3dg7 MUCONATE
CYCLOISOMERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ALA A 268
LYS A 266
THR A 301
THR A 304
 None
MUC  A1001 (-2.9A)
None
None
 1.42A 4z4eA-3dg7A:
4.1		 4z4eA-3dg7A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3dg7 MUCONATE
CYCLOISOMERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ALA A 268
LYS A 266
THR A 301
THR A 304
 None
MUC  A1001 (-2.9A)
None
None
 1.38A 4z4fA-3dg7A:
3.9		 4z4fA-3dg7A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3dg7 MUCONATE
CYCLOISOMERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ALA A 268
LYS A 266
THR A 301
THR A 304
 None
MUC  A1001 (-2.9A)
None
None
 1.42A 4z4iA-3dg7A:
4.0		 4z4iA-3dg7A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3dg7 MUCONATE
CYCLOISOMERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ALA A  90
ARG A 277
ALA A  85
GLU A  83
 None
 1.22A 5a06C-3dg7A:
3.1
5a06D-3dg7A:
3.1		 5a06C-3dg7A:
25.00
5a06D-3dg7A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 3dg7 MUCONATE
CYCLOISOMERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ALA A  98
GLY A  61
THR A  60
ILE A  62
ALA A   8
 None
 1.34A 5vyhA-3dg7A:
undetectable		 5vyhA-3dg7A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_A_9F2A302_1
(BETA-LACTAMASE)		 3dg7 MUCONATE
CYCLOISOMERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 TYR A  55
THR A  97
PRO A  49
THR A 301
ASP A 191
 None
None
None
None
MG  A2001 ( 2.6A)
 1.11A 6b69A-3dg7A:
undetectable
6b69B-3dg7A:
undetectable		 6b69A-3dg7A:
13.97
6b69B-3dg7A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_A_9F2A302_1
(BETA-LACTAMASE)		 3dg7 MUCONATE
CYCLOISOMERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 TYR A  55
THR A  97
PRO A  49
THR A 304
ASP A 191
 None
None
None
None
MG  A2001 ( 2.6A)
 1.37A 6b6aA-3dg7A:
0.0
6b6aB-3dg7A:
0.0		 6b6aA-3dg7A:
13.97
6b6aB-3dg7A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3dg7 MUCONATE
CYCLOISOMERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 GLY A 164
ASP A 171
ARG A 166
ARG A 165
 None
 1.23A 6dwdB-3dg7A:
undetectable
6dwdD-3dg7A:
undetectable		 6dwdB-3dg7A:
19.50
6dwdD-3dg7A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3dg7 MUCONATE
CYCLOISOMERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ARG A 166
ARG A 165
GLY A 164
ASP A 171
 None
 1.21A 6dwjB-3dg7A:
undetectable
6dwjD-3dg7A:
undetectable		 6dwjB-3dg7A:
19.50
6dwjD-3dg7A:
19.50